Suppression of nitric oxide synthesis by L-NAME reverses the beneficial effects of pioglitazone on scopolamine-induced memory impairment in mice

Allami, Nika; Javadi‐Paydar, Mehrak; Rayatnia, Farhoud; Sehhat, Kourosh; Rahimian, Reza; Norouzi, Abbas; Dehpour, Ahmad Reza

doi:10.1016/j.ejphar.2010.10.007

Cited by 49 publications

(33 citation statements)

References 46 publications

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“…; Allami et al . ). Since 2000, when Heneka et al ., suggested the therapeutic role of PPARγ agonist in Alzheimer's disease by preventing iNOS expression and neuronal cell death (McIntyre et al .…”

Section: Discussionmentioning

confidence: 97%

The increased gastroprotective effect of pioglitazone in cholestatic rats: role of nitric oxide and tumour necrosis factor alpha

Moezi

Janahmadi

Amirghofran

et al. 2014

Int J Experimental Path

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The prevalence of gastric ulcers is high in cholestatic patients, but the exact mechanism of this increased frequency remains uncertain. It has been shown that pioglitazone accelerates the healing of pre-existing gastric ulcers. The present study was designed to investigate the effect of pioglitazone, on the gastric mucosal lesions in cholestatic rats. Cholestasis was induced by surgical ligation of common bile duct and sham-operated rats served as control. Different groups of sham and cholestatic animals received solvent or pioglitazone (5, 15, 30 mg/kg) for 7 days. On the day eight rats were killed after oral ethanol administration and the area of gastric lesions was measured. The serums of rats were also collected to determine serum levels of tumour necrosis factor alpha (TNF-α), IL-1β and bilirubin. The ethanol-induced gastric mucosal damage was significantly more severe in cholestatic rats than sham-operated ones. Pretreatment with pioglitazone dose-dependently attenuated gastric lesions induced by ethanol in both sham and cholestatic rats, but this effect was more prominent in cholestatic ones. The effect of pioglitazone was associated with a significant fall in serum levels of TNF-α in cholestatic rats. L-NAME, a non-selective nitric oxide synthase (NOS) inhibitor, and decreased pioglitazone-induced gastroprotective effect in cholestatic rats, while aminoguanidine, a selective inducible NOS inhibitor, potentiated pioglitazone-induced gastroprotective effect in the cholestatic rats. Chronic treatment with pioglitazone exerts an enhanced gastroprotective effect on the stomach ulcers of cholestatic rats compared to sham rats probably due to constitutive NOS induction and/or inducible NOS inhibition and attenuating release of TNF-α.

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Section: Discussionmentioning

confidence: 97%

The increased gastroprotective effect of pioglitazone in cholestatic rats: role of nitric oxide and tumour necrosis factor alpha

Moezi

Janahmadi

Amirghofran

et al. 2014

Int J Experimental Path

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“…It is reasonable that the observed improvement in learning and memory in the Morris water maze test and the passive avoidance test was associated with the elevation of hippocampal ACh in pioglitazone plus scopolamine‐treated animals. Recent other studies have shown that acute administration of pioglitazone improved the acquisition and retrieval of spatial recognition memory impairment by scopolamine in mice, and the enhancing effect of pioglitazone on acquisition was dependant on the NO pathway [31] . It is well known that long‐term administration of pioglitazone may improve insulin‐mediated glucose disposal via activation of PPAR γ in liver and peripheral tissues in type 2 diabetic patients [5] .…”

Section: Discussionmentioning

confidence: 99%

PPARγ agonist pioglitazone improves scopolamine-induced memory impairment in mice

Guo

Tang

Jiang

et al. 2012

Journal of Pharmacy and Pharmacology

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“…; SigmaAldrich) was administered one time 20 min before the behavioral tests (n = 5 -6) using a dose that was chosen based on previous studies (1,12). ST101 (0.1 or 1 mg/kg, i.p.)…”

Section: Scopolamine Administrationmentioning

confidence: 99%

The Novel Cognitive Enhancer ST101 Enhances Acetylcholine Release in Mouse Dorsal Hippocampus Through T-type Voltage-Gated Calcium Channel Stimulation

et al. 2013

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Suppression of nitric oxide synthesis by L-NAME reverses the beneficial effects of pioglitazone on scopolamine-induced memory impairment in mice

Cited by 49 publications

References 46 publications

The increased gastroprotective effect of pioglitazone in cholestatic rats: role of nitric oxide and tumour necrosis factor alpha

The increased gastroprotective effect of pioglitazone in cholestatic rats: role of nitric oxide and tumour necrosis factor alpha

PPARγ agonist pioglitazone improves scopolamine-induced memory impairment in mice

The Novel Cognitive Enhancer ST101 Enhances Acetylcholine Release in Mouse Dorsal Hippocampus Through T-type Voltage-Gated Calcium Channel Stimulation

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