Suppression of pancreatic tumor growth by targeted arsenic delivery with anti-CD44v6 single chain antibody conjugated nanoparticles

Qian, Changtao; Wang, Yong; Chen, Yinting; Zeng, Linjuan; Zhang, Qiubo; Shuai, Xintao; Huang, Kaihong

doi:10.1016/j.biomaterials.2013.04.056

Cited by 66 publications

(50 citation statements)

References 32 publications

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“…30 The animals were monitored every three days for tumor growth and survival, and those animals that reached the pre-set end points (21 days after treatment) were sacrificed.…”

Section: In Vivo Efficacy Studiesmentioning

confidence: 99%

Combination of siRNA-directed Kras oncogene silencing and arsenic-induced apoptosis using a nanomedicine strategy for the effective treatment of pancreatic cancer

Zeng

Wang

et al. 2014

Nanomedicine: Nanotechnology, Biology and Medicine

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“…30 The animals were monitored every three days for tumor growth and survival, and those animals that reached the pre-set end points (21 days after treatment) were sacrificed.…”

Section: In Vivo Efficacy Studiesmentioning

confidence: 99%

Combination of siRNA-directed Kras oncogene silencing and arsenic-induced apoptosis using a nanomedicine strategy for the effective treatment of pancreatic cancer

Zeng

Wang

et al. 2014

Nanomedicine: Nanotechnology, Biology and Medicine

Self Cite

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“…Silicon NPs are also well-known as quantum dot (QD) agents and typically used for diagnostic systems [162]. Despite toxicity concerns about arsenic, arsenic trioxide (As 2 O 3 ) NPs have recently been considered a promising anticancer agent for solid tumors [143,163].…”

Section: Metalloid Nanoparticles and Cancermentioning

confidence: 99%

Metal, Metalloid, and Oxide Nanoparticles for Therapeutic and Diagnostic Oncology

Yazdi¹,

Sepehrizadeh²,

Mahdavi³

et al. 2016

Nano BioMed ENG

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Nanoparticles have comprehensively affected various sights of human life. Through the wide range of claims about nanosized particles and their functions, biomedical applications are of much interest among health care researchers due to the nanoparticles' potential for use in the process of disease diagnosis, control and treatment. In this regard, inorganic nanoparticles, which have high potential in diagnostic and therapeutic systems, have recently received much attention in oncology. Although inorganic nanoparticles initially seemed an appropriate tool for cancer imaging and diagnosis, their ability to attack cancerous cells as anticancer drugs or carriers in other drugs has also demonstrated promising results. The present review primarily provides a brief survey of various studies in which metal nanoparticles such as gold, silver, iron oxide, and metalloid nanoparticles viz. tellurium and bismuth were exploited for therapeutic or diagnostic purposes in oncology. Then the application of selenium nanoparticles as a therapeutic agent against cancer in in vitro and in vivo studies is reviewed in detail. Although inorganic nanoparticles seem to be useful tools for cancer imaging and diagnosis, their potential for attacking cancerous cells as anticancer substances or even carriers for anticancer medications should not be underestimated.

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“…Accumulation and retention within the tumour was significantly higher for CD44v6-targeted NPs than for the non-targeted controls. Furthermore, the targeted NPs inhibited tumour growth significantly more than the non-targeted NPs or free arsenic [67]. In another example, phage display technology was used to obtain a cell-internalising scFv to target c-Met; a tyrosine kinase receptor expressed on both tumour and endothelial cells [79].…”

Section: Delivery Of Cytotoxic Agentsmentioning

confidence: 99%

Antibody-Targeted Nanoparticles for Cancer Treatment

2016

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Nanoparticles are diverse and versatile with physical properties that can be employed for use in cancer medicine. Targeting nanoparticles using antibodies and antibody fragments could overcome some of the limitations seen with current targeted therapies. This review will discuss the role of antibody-targeted nanoparticles in the treatment of cancer: as delivery vehicles, targeted theranostic agents and in the evolving field of cancer hyperthermia.

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Suppression of pancreatic tumor growth by targeted arsenic delivery with anti-CD44v6 single chain antibody conjugated nanoparticles

Cited by 66 publications

References 32 publications

Combination of siRNA-directed Kras oncogene silencing and arsenic-induced apoptosis using a nanomedicine strategy for the effective treatment of pancreatic cancer

Combination of siRNA-directed Kras oncogene silencing and arsenic-induced apoptosis using a nanomedicine strategy for the effective treatment of pancreatic cancer

Metal, Metalloid, and Oxide Nanoparticles for Therapeutic and Diagnostic Oncology

Antibody-Targeted Nanoparticles for Cancer Treatment

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