Suppression of perception in migraine

Mulleners, Wim M.; Chronicle, Edward P.; Palmer, Jennifer A.; Koehler, Peter J.; Vredeveld, J.W.

doi:10.1212/wnl.56.2.178

Cited by 110 publications

(103 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In patients with migraine, it may be more difficult to suppress perception at the midrange intervals because of increased baseline cortical excitability, which may be caused by impaired intracortical inhibitory mechanisms [31]. The greater degree of suppression observed in chronic migraine compared with episodic migraine may be due to a more pervasive or persistent cortical hyperexcitability.…”

Section: Magnetic Suppression Of Perceptual Accuracymentioning

confidence: 99%

Mechanism of Chronic Migraine

Aurora

Kulthia

Barrodale

2011

Curr Pain Headache Rep

View full text Add to dashboard Cite

Chronic migraine typically evolves from episodic migraine over months to years in susceptible individuals. Headaches increase in frequency over time, becoming less intense but more disabling and less responsive to treatment. Results of electrophysiologic and functional imaging studies indicate that chronic migraine is associated with abnormalities in the brainstem that may be progressive. Additionally, chronic migraine is associated with a greater degree of impairment in cortical processing of sensory stimuli than is episodic migraine, perhaps due to a more pervasive or persistent cortical hyperexcitability. These findings fit with the model of migraine as a spectrum disorder, in which the clinical and pathophysiological features of migraine may progress over time. This progression is postulated to result from changes in nociceptive thresholds and ensuing central sensitization caused by recurrent migraine in susceptible individuals, for whom a variety of risk factors have been described. This may lead to changes in baseline neurologic function between episodes of headache, evident not only in electrophysiologic and functional imaging studies, but also as an increase in depression, anxiety, nonhead pain, fatigue, gastrointestinal disorders, and other somatic complaints that may occur after years of episodic migraine. From the current research and migraine models, a conceptualization of chronic migraine, in which relatively permanent and pervasive central changes that warrant novel and tolerable treatments have occurred, is emerging. This model also implies that prevention of chronic migraine is an important goal in the management of episodic migraine, particularly in individuals who exhibit risk factors for chronic transformation.

show abstract

Section: Magnetic Suppression Of Perceptual Accuracymentioning

confidence: 99%

Mechanism of Chronic Migraine

Aurora

Kulthia

Barrodale

2011

Curr Pain Headache Rep

View full text Add to dashboard Cite

show abstract

“…The finding of a shorter SEP recovery cycle in migraine children than in controls suggested a somatosensory system disinhibition [80], possibly due to abnormalities of inhibitory interneuron function, as suggested by psychophysiological and TMS studies [81,82]. Investigations into the high-frequency oscillations (HFOs) embedded in SEP, which are supposed to reflect spike activity in thalamo-cortical cholinergic fibres (early HFOs) and in cortical inhibitory GABAergic interneurons (late HFOs) were performed in two independent studies.…”

Section: Somatosensory Cortex Response Patterns In Migrainementioning

confidence: 99%

Electrophysiological response patterns of primary sensory cortices in migraine

Ambrosini

Schoenen

2006

J Headache Pain

View full text Add to dashboard Cite

Migraine is an ictal disorder characterised by a particular vulnerability of patients to sensory overload, both during and outside of the attack. Central nervous system dysfunctions are supposed to play a pivotal role in migraine. Electroneurophysiological methods, which aim to investigate sensory processing, seem thus particularly appropriate to study the pathophysiology of migraine. We have thus reviewed evoked potential studies performed in migraine patients. Although results are in part contradictory, these studies nonetheless demonstrate an interictal dysfunction of sensory cortices, and possibly of subcortical structures, in migraine with and without aura. The predominant abnormality is a deficient habituation of evoked responses to repeated stimuli, probably due to cortical, and possibly widespread neural, "dysexcitability".

show abstract

“…Motor symptoms in some migraine subtypes have also drawn attention to the hyperexcitability of motor cortex. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Transcranial magnetic stimulation (TMS) is a non-invasive tool to investigate physiology and excitability of both motor-and occipital cortices. 11,[21][22][23][24][25] The changes in motor threshold, latency and amplitude of motor evoked potential, central motor conduction time and cortical silent period after magnetic ABSTRACT: Objective: We evaluated motor and occipital cortex excitability in migraine patients using transcranial magnetic stimulation.…”

mentioning

confidence: 99%

Motor and Occipital Cortex Excitability in Migraine Patients

et al. 2006

View full text Add to dashboard Cite

Recent studies have demonstrated that central neuronal hyperexcitability has an important role in migraine pathogenesis. Hyperexcitability of occipital cortex has been proposed to be responsible for the elaboration of migraine attacks and visual aura. Motor symptoms in some migraine subtypes have also drawn attention to the hyperexcitability of motor cortex. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Transcranial magnetic stimulation (TMS) is a non-invasive tool to investigate physiology and excitability of both motor-and occipital cortices. 11,[21][22][23][24][25] The changes in motor threshold, latency and amplitude of motor evoked potential, central motor conduction time and cortical silent period after magnetic ABSTRACT: Objective: We evaluated motor and occipital cortex excitability in migraine patients using transcranial magnetic stimulation. Methods: In this study, we included 15 migraine patients with aura (MwA), 15 patients without aura (MwoA) between attacks, and 31 normal healthy controls. Motor thresholds at rest, amplitudes of motor evoked potentials, central motor conduction time and cortical silent period were measured by stimulation of the motor cortex by using 13.5 cm circular coil and recording from abductor digiti minimi muscle. Additionally, phosphene production and the threshold of phosphene production was determined by stimulation of the visual cortex with the same coil. Results: No significant differences were observed between the groups with respect to the motor thresholds, Motor evoked potential max/compound muscle action potential max (MEPmax/Mmax) amplitudes, central motor conduction times and duration of cortical silent period. Although not statistically significant, the proportion of the migraineurs with phosphene generation (90%) was found to be higher than that of normal controls (71%). Phosphene threshold levels in migraine patients, however, were significantly lower than those of the controls with MwA patients having the lowest levels. Conclusion: Our findings indicate that the occipital cortex, but not the motor cortex, is hyperexcitable in migraine patients. RÉSUMÉ: Excitabilité du cortex moteur et du cortex occipital chez les patients migraineux.Objectif: Nous avons évalué par stimulation magnétique transcrânienne l'excitabilité du cortex moteur et du cortex occipital chez des patients migraineux. Méthodes: Nous avons étudié entre les crises 15 patients ayant une migraine avec aura (MaA), 15 patients migraineux sans aura (MsA) et 31 témoins en bonne santé. Les seuils moteurs au repos, les amplitudes des potentiels évoqués moteurs (PÉM), le temps de conduction moteur central et la période de silence cortical ont été mesurés par stimulation du cortex moteur au moyen d'une spirale circulaire de 13,5 cm et enregistrement au niveau du muscle abducteur du petit doigt. De plus, la production de phosphènes et le seuil de production de phosphènes ont été déterminés par stimulation du cortex visuel avec la même spirale. Résultats: Nous n'avons observé aucune...

show abstract

Suppression of perception in migraine

Abstract: These findings suggest that inhibitory systems are activated to a lesser extent by TMS pulses in patients. This observation is in agreement with the hypothesized deficiency of intracortical inhibition of the visual cortex, at least in migraineurs with aura.

Cited by 110 publications

References 32 publications

Mechanism of Chronic Migraine

Mechanism of Chronic Migraine

Electrophysiological response patterns of primary sensory cortices in migraine

Motor and Occipital Cortex Excitability in Migraine Patients

Contact Info

Product

Resources

About