Suppression of Phytohemagglutinin Response by Fungi from a “Leukemia” House

Wray, Betty B.; Rushing, J B S Elisabeth; Boyd, C B S Rebecca; Schindel, M.

doi:10.1080/00039896.1979.10667430

Cited by 10 publications

(10 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Carcinogenic effects of fungal agents and aflatoxin are well established, but the mechanisms resulting in this phenomenon are not entirely clear. Few reports of fungal isolation from residences of patients with leukemias, including ALL, are available [154][155][156][157] and generally, their carcinogenic impacts are attributed to immunosuppression [155,156]. Mycotoxin-producing fungi from a residence associated with four patients with leukemia from three families has been reported and the leukemogenesis attributed to the immune depressive effects of mycotoxins [155].…”

Section: Infectionsmentioning

confidence: 99%

Etiology of Acute Leukemia. A Review

Tebbi¹

2021

Preprint

View full text Add to dashboard Cite

Acute leukemias constitute some of the most common malignant disorders. Despite significant progress made in the treatment of these disorders, their etiology remains unknown. A large and diverse group of genetic and environmental variables have been proposed. The role of a variety of factors, including pre-existing and acquired genetic mutations, exposure to radiation and various chemicals during pre-conception, pregnancy and throughout life have been explored. The effects of inherited genetic variations and disorders, pre-existing diseases, infectious agents, hobbies, occupations, prior treatments and a host of other factors have been proposed, but none is universally applicable to all cases. Variation in the incidence and prognosis based on the age, sex, race, type of the disease, geographic area of residence and other factors are intriguing, but remains unexplained. Advances in genomic profiling, including genome‐wide gene expression, DNA copy number, and single nucleotide polymorphism [SNP] genotype may shed some light on the role of genetics in these disparities. Separate two-hit hypothesis for the development of acute myeloblastic and lymphoblastic leukemia have been proposed. The latter combines genetics and infection factors resulting in leukemogenesis. A number of pre- and post-natal environmental conditions and exposure to infections, including a mycovirus infected Aspergillus flavus, have been suggested. The exact nature, timing, sequence of the events and mechanisms resulting in occurrence of leukemia requires further investigations. This review summarizes some of the above factors and the direction for future research on the etiology of acute leukemias.

show abstract

Section: Infectionsmentioning

confidence: 99%

Etiology of Acute Leukemia. A Review

Tebbi¹

2021

Preprint

View full text Add to dashboard Cite

show abstract

“…From these only Trichoderma was isolated in several sites in and around the ‘leukemia’ house but was not found in any of the control houses. Wray et al (1979) then returned focus on the home of a husband and wife who had both developed acute myelomonocytic leukemia. The husband a 69-year-old white, retired textile worker developed acute myelomonocytic leukemia first, while his wife received medical attention 5 months after his diagnosis, receiving a diagnosis of acute undifferentiated leukemia.…”

Section: Introductionmentioning

confidence: 99%

“…In 1976, a 42-year-old biochemist and his 28-year-old graduate student who had been working with purified aflatoxins for over a year, both developed adenocarcinoma of the colon within 3 months (Deger, 1976). Van Nieuwenhuize, et al analyzed the frequency of neoplasia over 11 years in factory workers exposed to chronic low levels of aflatoxin during production of peanut and flaxseed oils (Wray et al, 1979). The exposed group, receiving an estimated dose of 165–195 μg of aflatoxins, showed a significant increase in several types of cancer when compared to a control group of the same age.…”

Section: Introductionmentioning

confidence: 99%

“…The exposed group, receiving an estimated dose of 165–195 μg of aflatoxins, showed a significant increase in several types of cancer when compared to a control group of the same age. Workers exposed to aerosols from Stachybotrys-infected substrate absorbed enough toxin via the respiratory route to develop blood dyscrasias (Wray et al, 1979).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Employing volcanic tuff minerals in interior architecture design to reduce microbial contaminants and airborne fungal carcinogens of indoor environments

et al. 2011

View full text Add to dashboard Cite

Indoor volatile organic compounds (VOCs) have posed significant risks to human health since people have both shifted to a life spent, for the most part, indoors. Further, changes in materials used in the construction of buildings, furnishings, and tools either leak or encourage the production of VOCs. Whether these enclosed areas are residences, hospitals or workplaces (specifically composting facilities or closed farm buildings for raising livestock), VOCs can rise to levels that threaten people's health. VOCs can either originate from phenolic and benzene-like compounds in building materials and office furniture or from molds (fungi) growing inside improperly ventilated or sealed buildings. Regardless of the source, exposure to VOCs could lead to significant health concerns from sick-building syndrome, 'leukemia houses,' in-hospital fungemia cases or occupation-associated cancer epidemics due to aflatoxicosis. Innovative 21st-century building materials could offer solutions to these challenges. We propose that volcanic materials, clays and minerals (volcanic tuff, modified clay montmorillonite and mineral clinoptilolite), in their original or chemically modified form, could act like synthetic lungs in building walls, breathing and filtering VOCs, and thus limiting human exposure to disease.

show abstract

“…Our series of 12 probable spouse pairs increases the total number of such spouse pairs in the medical literature to about 40 (Street & Allen, 1950;Mazur & Strauss, 1951;Devore & Doan, 1957;Milham, 1964;Amos et al, 1967;Kyle et al, 1971;Berliner & Dristenfeld, 1972;Dworsky & Henderson, 1974;Pietruszk et al, 1976;Hazen & Michel, 1977;Ly et al, 1978;Kardinal, 1978;Wray et al, 1979;Brugiatelli et al, 1980;Kefford et al, 1980;Dougan et al, 1980). Previously, the largest reported series of such malignancies occurring in spouse pairs was 7, as reported by Milham (1964).…”

mentioning

confidence: 99%