Suppression of Proinflammatory Cytokines by Etlingera alba (A.D.) Poulsen Rhizome Extract and Its Antibacterial Properties

Abstract

Etlingera alba is one of the Etlingera plants that has not been studied intensively. Plants that belong to the same genus have similar constituents and pharmacological activities. Thus, we aim to investigate the chemical composition and pharmacological activities, namely, anti-inflammatory and antibacterial properties, of E. alba rhizome extract (EA). The chemical constituent was detected using the test tube method. The inflammatory model rats were obtained by inducing them with 1% carrageenan, and their palm edema volume and cytokine levels, namely, IL-6, IL-12, and TNF-α, were measured. Antibacterial activity was performed with broth microdilution. The phytochemical screening of EA was detecting alkaloids, flavonoids, tannins, steroids, and phenols. The EA has anti-inflammatory activity by reducing the palms’ edema volume and cytokine levels (IL-6, IL-12, and TNF-α), and the optimal concentration was 400 mg/kg body weight (BW). On the other hand, EA also exhibited antibacterial properties against E. coli and S. enterica. In conclusion, similar to other Etlingera plants, EA also demonstrates pharmacological activities, namely, anti-inflammatory and antibacterial properties.

Formulasi Gel dari Niosom Elastik Span 80 Ekstrak Etanol Rimpang Etlingera alba dengan Variasi Karbopol sebagai Gelling Agent

“…E. alba berpotensi sebagai antiinflamasi dengan mengurangi edema rat palm dan tumor-necrosisfactor-alpha (TNF-⍺), Tingkat-Interleukin6 (IL-6), dan Interleukin 12 (IL12). E. alba juga memiliki sifat antibakteri terhadap Salmonella enterica dan Escherichia coli [5]. Ekstrak etanol rimpang E. alba juga diketahui bersifat antikanker dan antimetastatik terhadap sel kanker payudara [6].…”

Chemotaxonomy in the Etlingera Genus from Sulawesi, Indonesia: Design and molecular docking of antioxidant marker

“…Several endemic medicinal plants of Sulawesi that have been studied include Alpinia monopleura K.Schum. (Yodha et al 2023), Meistera (Musdalipah et al 2021a,b), Polygonum (Sahidin et al 2019) and Etlingera (Sahidin et al 2018;Hamsidi et al 2021;Wahyuni et al 2021a,b;Sahidin et al 2022;Wahyuni et al 2022). Etlingera is one of the important genera in the Zingiberaceae family because of its potential uses.…”

In-Vitro Anticancer Activity of Chemical Constituents from Etlingera alba Poulsen against Triple Negative Breast Cancer and in silico Approaches towards Matrix metalloproteinase-1 Inhibition

“…E. alba has pharmacological activity, including antiinflammatory by reducing rat palm edema and tumor necrosis factor-alpha (TNF-⍺), , and Interleukin-12 (IL-12) levels. It also has antibacterial activity against Escherichia coli and Salmonella enterica (Hamsidi et al, 2021). It is an endemic plant that is mainly found in Sulawesi, thereby potentially exploring its pharmacological activity.…”