Suppression of Release of Interstitial Cell-Stimulating Hormone by Chronic Intraventricular Treatment with Melatonin in Adult Male Dogs

Yamashita, Kazukuni; Shimizu, Takeshi; Mieno, Masahiro; Kawao, Kunihiko

doi:10.1620/tjem.111.387

Cited by 1 publication

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“…Some of these reports suggest that melatonin acts within the brain to reduce LH secretion (Fraschini, Mess, Piva & Martini, 1968;Kamberi, Mical & Porter, 1970;Fraschini, Collu «fc Martini, 1971 ;Yamashita, Shimizu, Mieno & Kawao, 1973). It is undecided whether melatonin has in addition a direct inhibitory effect upon the anterior pituitary gland (Fraschini et al 1968;Kamberi et al 1970;Martin & Klein, 1976;Moguilevsky et al 1976;Martin, Engel «fc Klein, 1977).…”

Section: Introductionmentioning

confidence: 99%

Inhibition by Melatonin of the Pituitary Response to Luteinizing Hormone Releasing Hormone in Vivo

Yamashita¹,

Mieno²,

Shimizu³

et al. 1978

Journal of Endocrinology

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The rate of secretion of 17-oxosteroids by the testes of anaesthetized dogs in vivo was used as an index of LH secretion. Intracarotid injection of luteinizing hormone releasing hormone (LH-RH, 1, 5 or 10 microgram/kg body wt) resulted in an increase in the testicular 17-oxosteroid secretion which was roughly proportional to the dose administered and which reached a maximum 60 min after the injection. Testicular output of 17-oxosteroids was unaffected by administration of melatonin (10 or 100 microgram/kg body wt) into the carotid artery. When LH-RH (5 microgram/kg) was injected into the carotid artery 3 h after intracarotid injection of melatonin (10 or 100 microgram/kg), the testicular response to LH-RH was considerably diminished. Pretreatment with melatonin (100 microgram/kg) did not alter the testicular response to human chorionic gonadotrophin (20 i.u./kg body wt) given i.v. Is is concluded that melatonin may act directly on the anterior pituitary gland in dogs to inhibit the LH-RH-induced release of LH.

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