Suppression of spectral interference in dual-elemental analysis of single particles using triple quadrupole ICP-MS

An Approach Based on an Increased Bandpass for Enabling the Use of Internal Standards in Single Particle ICP-MS: Application to AuNPs Characterization

“…However, the method may not be so straightforward for species of lower m / z , as they are more affected by spectral interferences. For such cases, the analysis could be eased using an ICP-MS/MS instrument [ 42 , 43 ]. Moreover, the bandpass mode would enable the simultaneous (in the same measurement run) characterization of both Pt and AuNPs when in the absence of matrix effects (no IS required).…”

Particle generated spectral interferences in single particle ICP-MS: a roadblock to accurate nanometrology

“…22 A high resolution ICP-MS such as a sector eld (SF-ICP-MS) can also provide the resolution needed to resolved doubly charged interferences, or multiple quadrupoles can be used to eliminate the interferant. 9,23 On a quadrupole ICP-MS, extreme care must be taken to avoid particle generated doubly charged interferences. Screening environmental samples for suspected interferants based on isotopic distributions, crustal abundances, and second ionization potentials is suggested as the best means to avoid reporting spICP-MS data with false positives.…”

“…8 In contrast, particle generated polyatomic and doubly charged interferences in spICP-MS have received little attention, and the few studies considering them do not provide a comprehensive investigation. 9 We hypothesize that during ablation and ionization in the plasma, NPs behave similarly to dissolved ions, and therefore a fraction of the ion cloud from an individual NP will be converted to polyatomic ions or doubly charged ions. If the ion cloud is large enough, the fraction of ions that form polyatomic or doubly charged species will be recorded as a peak in the mass spectrum, resulting in false positive particle detections for certain elements.…”

Atomic spectrometry update: review of advances in the analysis of metals, chemicals and materials

“…Continuing the theme of investigations into the fundamentals of SP-ICP-MS , Chun et al investigated the possibility of making these measurements with a triple quadrupole (TQ) ICP-MS instrument. 255 The instrument was tuned using a process and a model (which was fully described), whereby the first quadrupole would allow transmission of more than one m / z but not potential polyatomic interferences. This is known as bandpass mode.…”