Suppression of the Early Inflammatory Response in the Sheep by Strophanthin G

Lancaster, M. C.; Vegad, J. L.

doi:10.1038/213840b0

Cited by 15 publications

(12 citation statements)

References 7 publications

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“…The time course of local tissue inflammation was in accord with earlier studies of vascular permeability and neutrophil infiltration, 12,15 while the systemic acute phase response was in accord with studies of the response to turpentine injection in calves 20 and mice 27 . Haptoglobin concentrations induced by 0.2 mL turpentine were higher than those seen during experimental fly strike 28 and mulesing 2,29 and exceed the reference range for clinically normal sheep 30 .…”

Section: Discussionsupporting

confidence: 82%

“…Oil of turpentine is a chemical irritant that has been used in many species to induce lameness and sterile inflammation. Among ruminants, inflammatory responses to injection of turpentine have been studied in sheep, 12–19 cattle 20 and buffalos 21 . Doses of 0.1 to 0.25 mL have been injected in fetuses, lambs and adult sheep.…”

mentioning

confidence: 99%

“…Doses of 0.1 to 0.25 mL have been injected in fetuses, lambs and adult sheep. Intradermal injection in sheep causes a bi‐phasic increase in vascular permeability 12 and a cellular infiltrate dominated by neutrophils in the first 24 h 15 . At a dose of 0.25 mL in adult sheep, the inflammatory response progresses to abscess formation from 3 to 7 days 19 .…”

mentioning

confidence: 99%

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Development of a lameness model in sheep for assessing efficacy of analgesics

Colditz

Hervault

et al. 2011

Australian Veterinary Journal

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Section: Discussionsupporting

confidence: 82%

mentioning

confidence: 99%

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Development of a lameness model in sheep for assessing efficacy of analgesics

Colditz

Hervault

et al. 2011

Australian Veterinary Journal

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“…This is in conformity with the finding of similar suppression of increased vascular permeability induced by turpentine in the skin (Ito & Böhm, 1986), and also in the pleuro-peritoneum (Jain et al, 1982). The findings are also in agreement with those reported in mammalian inflammation (Spector & Willoughby, 1959, 1963Hurley & Spector, 1965;Lancaster & Vegad, 1967;Vegad, 1979).…”

supporting

confidence: 82%

Effects of anti‐inflammatory drugs on increased vascular permeability in acute inflammatory response in the chicken

Jain¹,

Vegad²,

Katiyar³

et al. 1995

Avian Pathology

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“…The first report on the influence of CGs on inflammatory processes was published in 1967: Lancaster and Vegad [31] found that pretreatment with ouabain (also known as g-strophanthin) (100 µg/kg bodyweight; ▶ Fig. 3) reduced the turpentine-triggered early signs of inflammation (edema formation) in the skin and pleural cavity of sheep.…”

Section: Acute Inflammationmentioning

confidence: 99%

New Knowledge About Old Drugs: The Anti-Inflammatory Properties of Cardiac Glycosides

2017

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In the 19th century, cardio-active steroid glycosides, shortly cardiac glycosides, were scientifically established as drugs against heart failure. Their in vivo, cellular, and molecular actions as well as their predominant target, Na+-K+-ATPase, have been comprehensively investigated in the 20th century and the discovery of endogenous cardiac glycosides has fostered this research field. In the last years, however, results from clinical trials and meta-analyses have questioned their therapeutic value due to efficacy and safety issues. This has led to a considerable decline of their usage. Beyond the cardiovascular system, cardiac glycosides have been increasingly recognized as antitumor compounds and Na+-K+-ATPase has evolved into a promising drug target in oncology. A wealth of review articles exists that intensively discuss these topics. Surprisingly, the anti-inflammatory actions of cardiac glycosides, which were discovered in the 1960s, have so far hardly been perceived and have not yet been summarized. This review provides an overview of the in vivo and in vitro actions of cardiac glycosides on inflammatory processes and of the signaling mechanisms responsible for these effects: cardiac glycosides have been found to decrease inflammatory symptoms in different animal models of acute and chronic inflammation. Regarding the underlying mechanisms most research has focused on leukocytes. In these cells, cardiac glycosides primarily inhibit cell proliferation and the secretion of proinflammatory cytokines.

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Suppression of the Early Inflammatory Response in the Sheep by Strophanthin G

Cited by 15 publications

References 7 publications

Development of a lameness model in sheep for assessing efficacy of analgesics

Development of a lameness model in sheep for assessing efficacy of analgesics

Effects of anti‐inflammatory drugs on increased vascular permeability in acute inflammatory response in the chicken

New Knowledge About Old Drugs: The Anti-Inflammatory Properties of Cardiac Glycosides

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