Suppression of the mechanisms of stone formation by a flavonoid-enriched ethyl acetate fraction of aerial and underground parts of Aerva lanata (Linn.) Juss. ex Schult

Objectives The study was carried out to evaluate the in vivo antiurolithic efficaciousness of an ethyl acetate fraction of Aerva lanata (EAFAL) derived from the hydromethanolic extract of its aerial parts (HMEAL). Methods In vivo pharmacological potency of EAFAL was assessed by ethylene glycol (EG) induced urolithiasis model in male Wistar albino rats. Urine samples of the animals were analysed for physical parameters, stone promoters, inhibitors along with an evaluation of the biochemical parameters of serum and kidneys. Histopathological investigation of the kidneys was done. The fraction was further subjected to LC-MS and HPLC for its phytochemical evaluation. Key findings EAFAL demonstrated a significant antiurolithic effect by a restoration of the balance between urinary promoters and inhibitors along with an amelioration of the urinary pH. The abnormally elevated levels of serum nitrogenous substances, calcium, albumin, globulin, total protein along with altered renal calcium, oxalate and uric acid were also alleviated significantly followed by an improvement of the histopathological aberrancies. Phytochemical analysis showed evidence of phenolic components and flavonoids. Conclusions The current findings prove the beneficial role of phenolic and flavonoid rich EAFAL in ameliorating urolithiasis induced abnormalities of urine, serum and kidneys.

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Antiurolithic efficacy of a phenolic rich ethyl acetate fraction of the aerial parts of Aerva lanata (Linn) Juss. ex Schult. in ethylene glycol induced urolithic rats

Mandal

Madan

Ahmad

et al. 2021

Journal of Pharmacy and Pharmacology

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Aerva lanata; A cure or a cause for kidney diseases; A brief overview

Uluwaduge

2022

IJKIU

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At present the phyto-preparations are widely used in clinical practice and among them Aerva lanata (A. lanata) is commonly known as “Polpala” in Sinhalese, which is prescribed to alleviate kidney diseases in Complementary and Ayurvedic Medicine (CAM). The infusion of the plant extract has resolved urolithiasis and has induced diuresis in patients relying on CAM therapy. Scientific data supports this traditional claim. However, a controversy exists that the prolong use of the plant material may cause renal damage. Scientific literature also does not put forth the negative effects of using a long-term basis, though the dried plant preparations are readily available in the form of herbal tea in many countries. Therefore, this overview is a compilation of both the beneficial and detrimental effects of the use of plant material as a treatment in kidney diseases. Evaluation of the current literature supports the belief of nephrotoxicity in long term administration over its reported nephroprotection. Thus, the author reports that people who tend to self-medicate with A. lanata should be vigilant due to its possible adverse effects.

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Suppression of the mechanisms of stone formation by a flavonoid-enriched ethyl acetate fraction of aerial and underground parts of Aerva lanata (Linn.) Juss. ex Schult

Cited by 2 publications

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Antiurolithic efficacy of a phenolic rich ethyl acetate fraction of the aerial parts of Aerva lanata (Linn) Juss. ex Schult. in ethylene glycol induced urolithic rats

Antiurolithic efficacy of a phenolic rich ethyl acetate fraction of the aerial parts of Aerva lanata (Linn) Juss. ex Schult. in ethylene glycol induced urolithic rats

Aerva lanata; A cure or a cause for kidney diseases; A brief overview

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