Suppression of the Response of Lymphocytes to Phytohemagglutinin in Rubella

McMorrow, Lydia E.; Vesikari, Timo; Wolman, Sandra R.; Giles, Joan P.; Cooper, Louis Z.

doi:10.1093/infdis/130.5.464

Cited by 24 publications

(11 citation statements)

References 13 publications

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“…In humans, viral infection or vaccination with attenuated viruses is associated with transient depression in the host immune defenses [11], and this has been clearly demon strated for rubella, herpes simplex, measles, cytomegalo virus and Epstein-Barr virus [9,13,14,19] as well as for influenza [10]. The same phenomenon has been observed after vaccination with attenuated living virus [8,15], This immunosuppression may presumably be responsible for the increased susceptibility to other viruses or other bac terial infections such as can be observed, for example, after measles.…”

Section: Discussionmentioning

confidence: 99%

Impaired Humoral and Cell-Mediated Immune Responses in Dialyzed Patients after Influenza Vaccination

Cappel

Beers

Liesnard

et al. 1983

Nephron

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The antibody and cell-mediated immune responses after influenza vaccination were compared in 33 patients with chronic bronchitis and in 40 hemodialyzed patients. The results suggest a moderate impaired response in the hemodialyzed patients since the antibody titers and the level of cell-mediated immunity were consistently lower in these patients as compared to those suffering from chronic bronchitis. Nevertheless, the vaccine elicited an immune response in all the pre-vaccine seronegative dialyzed patients.

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Section: Discussionmentioning

confidence: 99%

Impaired Humoral and Cell-Mediated Immune Responses in Dialyzed Patients after Influenza Vaccination

Cappel

Beers

Liesnard

et al. 1983

Nephron

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“…Possibility (iii) would probably not be covered for rubella virus by the examination of synovial membrane eluates as the complexes could be inside phagocytic cells, or, if free in interstices of the membrane, lost during the washing process. As for possibility (iv), rubella infected lymphocytes have been shown to have a decreased response to phytohaemagglutinin stimulation (McMorrow et al, 1974;Vesikari and Biumovici-Klein, 1975) and decreased responsiveness to phytohaemagglutinin and other antigens has been observed in RA synovial lymphocytes (G. S. Panayi, personal communication;Hedberg et al, 1971;Astorga and Williams, 1969). However, our limited observations on synovial lymphocytes do not indicate that this anergy is due to the presence of rubella virus coded antigens in the lymphocyte membrane.…”

Section: Discussionmentioning

confidence: 69%

Rubella virus and rheumatoid arthritis.

Hart¹,

Marmion²

1977

Annals of the Rheumatic Diseases

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“…Munyer et al (12) postulated that a mild viral infection, i.e., one produced by an attenuated virus, was unable to suppress the lymphocyte response to a strong mitogen. More recently, McMorrow et al (11) demonstrated that the degree of suppression of lymphocyte transformation to PHA by rubella virus was directly related to the virulence of the strain of the virus.…”

Section: Discussionmentioning

confidence: 99%

Variable effect of encephalomyocarditis virus on host defense mechanisms

Faden¹,

Glasgow²,

Overall³

1978

Infect Immun

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A number of viruses have been shown to suppress a variety of host defense mechanisms. To further define the effect of a viral infection on host resistance, a number of parameters were examined during the course of a lethal encephalomyocarditis virus infection of mice. The peripheral lymphocyte count, the induction of interferon in spleen cells by Newcastle disease virus, and the proportion of B cells in the spleen were all decreased or suppressed. In contrast, the responsiveness of spleen lymphocytes to phytohemagglutinin, the delayed-type skin hypersensitivity to dinitrofluorobenzene, and the proportion of T cells in the spleen remained normal. These results indicate that a viral infection may have divergent effects on different parameters of host resistance and emphasize the need to examine several functions before drawing conclusions about the effect of viral infections on host defense mechanisms.

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Suppression of the Response of Lymphocytes to Phytohemagglutinin in Rubella

Cited by 24 publications

References 13 publications

Impaired Humoral and Cell-Mediated Immune Responses in Dialyzed Patients after Influenza Vaccination

Impaired Humoral and Cell-Mediated Immune Responses in Dialyzed Patients after Influenza Vaccination

Rubella virus and rheumatoid arthritis.

Variable effect of encephalomyocarditis virus on host defense mechanisms

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