Suppressive Effect of Natural Sesquiterpenoids on Inducible Cyclooxygenase (COX-2) and Nitric Oxide Synthase (iNOS) Activity in Mouse Macrophage Cells

Lee, Sang Kook; Hong, Chai-Hee; Huh, Sun-Kyung; Kim, Sun-Sook; Oh, O-Jin; Min, Hye‐Young; Park, Kwang-Kyun; Chung, Won Yoon; Hwang, Jae-Kwan

doi:10.1615/jenvironpatholtoxicoloncol.v21.i2.70

Cited by 66 publications

(55 citation statements)

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“…Xanthorrhizol, a sesquiterpenoid isolated from the rhizome of Curcuma xanthorrhiza (Zingiberaceae), exhibits various biological activities including antibacterial effect, antifungal effect, preventive effects against cisplatin-induced hepatotoxicity and nephrotoxicity, and neuroprotective activity (6 -8). In our previous studies on carcinogenesis, xanthorrhizol suppressed cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression in lipopolysaccharide (LPS)-induced RAW 264.7 cells and exhibited antimetastasis activity in a mouse spontaneous lung metastasis model (9,10). Recently, we also reported cancer chemopreventive activity mediated by xanthorrhizol and a plausible mechanism of action in a mouse two-stage carcinogenesis model (11).…”

Section: Introductionmentioning

confidence: 99%

Xanthorrhizol, a Natural Sesquiterpenoid, Induces Apoptosis and Growth Arrest in HCT116 Human Colon Cancer Cells

Kang¹,

Park

Chung

et al. 2009

J Pharmacol Sci

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Abstract. Xanthorrhizol is a sesquiterpenoid from the rhizome of Curcuma xanthorrhiza. In our previous studies, xanthorrhizol suppressed cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, inhibited cancer cell growth, and exerted an anti-metastatic effect in an animal model. However, the exact mechanisms for its inhibitory effects against cancer cell growth have not yet been fully elucidated. In the present study, we investigated the growth inhibitory effect of xanthorrhizol on cancer cells. Xanthorrhizol dose-dependently exerted antiproliferative effects against HCT116 human colon cancer cells. Xanthorrhizol also arrested cell cycle progression in the G0/G1 and G2/M phase and induced the increase of sub-G1 peaks. Cell cycle arrest was highly correlated with the downregulation of cyclin A, cyclin B1, and cyclin D1; cyclin-dependent kinase 1 (CDK1), CDK2, and CDK4; proliferating cell nuclear antigen; and inductions of p21 and p27, cyclin-dependent kinase inhibitors. The apoptosis by xanthorrhizol was markedly evidenced by induction of DNA fragmentation, release of cytochrome c, activation of caspases, and cleavage of poly-(ADP-ribose) polymerase. In addition, xanthorrhizol increased the expression and promoter activity of pro-apoptotic non-steroidal antiinflammatory drug-activated gene-1 (NAG-1). These findings provide one plausible mechanism for the growth inhibitory activity of xanthorrhizol against cancer cells.

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Section: Introductionmentioning

confidence: 99%

Xanthorrhizol, a Natural Sesquiterpenoid, Induces Apoptosis and Growth Arrest in HCT116 Human Colon Cancer Cells

Kang¹,

Park

Chung

et al. 2009

J Pharmacol Sci

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“…Hence, it appears that the analgesic effect of essential oil from S. indicus flower is mainly due to the combined effect of terpenes and sesquiterpenes but not only by the majority constituents [29][30][31]. The terpenes present in the oil of plant S. indicus flower that may responsible for blocking the release of endogenous substances which excite the pain in nociceptive pathway [32].…”

Section: Discussionmentioning

confidence: 99%

Topical Analgesic Activity of Essential Oil Extracted From Spharenthus Indicus (Asteraceae)

Padhan¹,

Sriballav²,

Arnabaditya³

2017

Asian J Pharm Clin Res

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Objective: The objective of this study was to evaluate the topical analgesic effects of essential oil extracted from Sphaeranthus indicus (Asteraceae). Methods:The essential oil was extracted from fresh flower of S. indicus. Topical ointment containing essential oil was investigated for analgesic activity in rat using hot-plate method. Diclofenac sodium gel was taken as standard drug. Result:The analgesic activity of topical preparation was observed in the early phase. The analgesic activity of topical preparation containing 2% S. indicus flower essential oil showed significant activity (11.5±0.34 and 11.83±0.40) comparative to standard drug diclofenac sodium (11.83±0.31 and 12.66±0.61) at 90 and 120 minutes of application of drug by hot-plate method (p<0.001). Conclusion:Hence, the study validates the traditional use of S. indicus to relive pain.

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“…It is proved that sesquiterpenoids such as α and β tumerones, curlone, are the turmeric oil constituents possessing antioxidative and mosquitocidal properties (Jayaprakashaet al, 2002;Roth et al, 1998). Production of E2 and NO prostaglandin was also inhibited utilizing these components Lee et al, 2002). In recent years, natural product substrates provides an effective sources for anti-cancer treatment (Pan et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Sulphureuine B, a drimane type sesquiterpenoid isolated from <i>Laetiporus sulphureus</i> induces apoptosis in glioma cells

Zhang¹,

Wen²,

Zhang³

et al. 2015

Bangladesh J Pharmacol

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Sulphureuine B, a drimane type sesquiterpenoid isolated from Laetiporus sulphureus induces apoptosis in glioma cells BJP IntroductionMalignant gliomas are the major life-threatening primary brain tumor with the average survival of less than a year due to the ineffectiveness of radiation and other medical care (Legler et al., 1999). Glioblastomas existing as a spread over to wide area with invasion into typical brain but customarily repeated or developed after radiation as focal point (Garden et al., 1991), indicating that only a small proportion of tumor cells are accountable for regrowth. Even though there occurs the availability of treatment such as combination of surgery, radiation, chemotherapeutics for malicious glioblastomas, still these are considered as locally protruding tumors suffered with poor prediction. A survey from European Organization for Research and Treatment of Cancer (Stupp et al., 2005) displayed that the total viability was increased two more months with associated adjuvant radiation therapy with temozolomide chased by associated temozolomide when compared with the radiation treatment alone. Glioblastomas are very harmful neoplasms which can manifest clear angiogenesis with increased vascular endothelial growth factor expressions which further assist blood vessel production using precursors of endothelium (Plate et al., 1992, Plate et al., 1994. Also it is proved that in the glioblastoma medical care, either surgical treatment followed by radiation treatment or the surgery followed by chemotherapy yields a mean survival of less than 12 months (Fine et al., 1993). Earlier immunotherapy treatments for glioma tumor have concentrated on submissive and non-specific strategies and resulted uncertain benefits (Zeltzer et al., 1999).Sesquiterpenoids are compounds possessing 15-carbons and can be obtained biosynthetically from 5-carbon isoprene units or can be industrially synthesized using feed stocks of monoterpenoids. These compounds attracted industrial attention due to their beneficial to the characteristic flavors and smell of spices, flowers, AbstractA drimane type sesquiterpenoids, sulphureuine B was isolated from the edible mushroom Laetiporus sulphureus and its antiproliferative properties were investigated using U-87MG glioma cells. It was observed that sulphureuine B-induced apoptosis in U-87MG cells and the mechanisms involved are endoplasmic reticulum stress, mitochondrial and death receptor mediated pathways. Endoplasmic reticulum stress was identified from the results of enormous cytoplasmic vacuolation, CHOP elevation and caspase-12 cleavage. Further, we found that treatment of sulphureuine B-induced PERK, IRE1α, and ATF6α activations. In addition, sulphureuine B-induced Bcl-2 downregulation, cleavage of PARP, and caspase-8 activation were also affected. All these experimental results clearly revealed that sulphureuine B-induced apoptosis mediated through endoplasmic reticulum stress, mitochondrial, and death receptor signaling pathways. Article Info

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Suppressive Effect of Natural Sesquiterpenoids on Inducible Cyclooxygenase (COX-2) and Nitric Oxide Synthase (iNOS) Activity in Mouse Macrophage Cells

Cited by 66 publications

References 0 publications

Xanthorrhizol, a Natural Sesquiterpenoid, Induces Apoptosis and Growth Arrest in HCT116 Human Colon Cancer Cells

Xanthorrhizol, a Natural Sesquiterpenoid, Induces Apoptosis and Growth Arrest in HCT116 Human Colon Cancer Cells

Topical Analgesic Activity of Essential Oil Extracted From Spharenthus Indicus (Asteraceae)

Sulphureuine B, a drimane type sesquiterpenoid isolated from <i>Laetiporus sulphureus</i> induces apoptosis in glioma cells

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