Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils

Vinolo, Marco Aurélio Ramirez; Rodrigues, Hosana Gomes; Hatanaka, Elaine; Sato, Fábio Takeo; Sampaio, Sandra Coccuzzo; Curi, Rui

doi:10.1016/j.jnutbio.2010.07.009

Cited by 570 publications

(429 citation statements)

References 46 publications

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“…Acetate has also been shown to actively suppress NF-ĸB activity in Colo320DM cells (Tedelind et al, 2007). Under inflammatory conditions, the addition of acetate has been shown to inhibit human neutrophil migration toward C5a or fMLP in a GPR43-dependent manner (Vinolo et al, 2011). Phenylacetamide, a human GPR43 agonist, mimics these effects.…”

Section: Discussionmentioning

confidence: 99%

“…For example, acetate inhibits the histone deacetylase (HDAC) activity via tissue-or cellspecific mechanisms (Waldecker et al, 2008;Soliman and Rosenberger, 2011). Rodent neutrophils exposed to acetate undergo global inhibition of HDAC activity (Vinolo et al, 2011). Treatment with 1 mM acetate significantly reduces the HDAC activity and increases global histone acetylation in human macrophages, corresponding to a decrease in inflammatory cytokine [interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-a] production (Kendrick et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Acetate promotes the release of reactive oxygen species in mouse neutrophils by activating GPR43 (Maslowski et al, 2009). Acetate inhibits human neutrophil migration toward C5a or formyl-methionyl-leucyl-phenylalanine (fMLP) in a GPR43-dependent manner under inflammatory conditions (Vinolo et al, 2011). Acetate also induces partial lysosomal membrane permeabilization and the subsequent release of cathepsin D to the cytosol of apoptotic colorectal cancer cells (Marques et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Apoptotic effect of sodium acetate on a human gastric adenocarcinoma epithelial cell line

Yuan

Zhang

Jin³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. The objective of this study was to investigate the effect of sodium acetate on the viability of the human gastric adenocarcinoma (AGS) epithelial cell line. AGS cells were exposed to a range of concentrations of sodium acetate for different periods of time, and the sodium acetate-induced cytotoxic effects, including cell viability, DNA fragmentation, apoptotic gene expression, and caspase activity, were assessed. The changes in these phenotypes were quantified by performing a lactate dehydrogenase cell viability assay, annexin V staining, terminal deoxynucleotidyl transferase-mediated dUTP nickend labeling (TUNEL), and several caspase activity assays. In vitro studies demonstrated that the cytotoxicity of sodium acetate on the AGS cell line were dose-and time-dependent manners. No differences 2 Y. Xia et al. Genetics and Molecular Research 15 (4): gmr.15048375 were found between the negative control and sodium acetate-treated cells stained with annexin V and subjected to the TUNEL assay. However, caspase-3 activity was increased in AGS cells exposed to sodium acetate. Overall, it was concluded that sodium acetate exerted an apoptotic effect in AGS cells via a caspase-dependent apoptotic pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Apoptotic effect of sodium acetate on a human gastric adenocarcinoma epithelial cell line

Yuan

Zhang

Jin³

et al. 2016

Genet. Mol. Res.

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“…Further, propionate and butyrate have been shown to inhibit the expression of proinflammatory mediators (TNF-CINC-NO s to involve attenuation of NF-B activation [85]. Moreover, the prebiotics such as FOS, GOS, inulin and resistant starch have been shown to affect specific probiotic strains that drive the induction of Tregs by different mechanisms (Table 2) [86][87][88][89].…”

Section: Tnf-tmentioning

confidence: 99%

Induction of regulatory T cells: A role for probiotics and prebiotics to suppress autoimmunity

Dwivedi

Kumar

Laddha³

et al. 2016

Autoimmunity Reviews

122

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“…Although these three SCFAs are rapidly assimilated into host carbohydrates and lipids-providing ;10% of our daily energy requirements (7)-there are clear differences in the way each is metabolized: propionate is primarily a precursor for gluconeogenesis, whereas acetate and butyrate are rather incorporated into fatty acids and cholesterol (8). Besides serving as an energy source, SCFAs also regulate metabolism by inhibition of histone deacetylases and chain-length-dependent activation of the endogenous G-protein-coupled receptor (GPR) 41 and 43 (9)(10)(11). The longer butyrate is more selective for GPR41, the shorter acetate is more selective for GPR43, and propionate binds to both receptors (12,13).…”

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confidence: 99%

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

et al. 2015

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Short-chain fatty acids (SCFAs) are the main products of dietary fiber fermentation and are believed to drive the fiber-related prevention of the metabolic syndrome. Here we show that dietary SCFAs induce a peroxisome proliferator–activated receptor-γ (PPARγ)–dependent switch from lipid synthesis to utilization. Dietary SCFA supplementation prevented and reversed high-fat diet–induced metabolic abnormalities in mice by decreasing PPARγ expression and activity. This increased the expression of mitochondrial uncoupling protein 2 and raised the AMP-to-ATP ratio, thereby stimulating oxidative metabolism in liver and adipose tissue via AMPK. The SCFA-induced reduction in body weight and stimulation of insulin sensitivity were absent in mice with adipose-specific disruption of PPARγ. Similarly, SCFA-induced reduction of hepatic steatosis was absent in mice lacking hepatic PPARγ. These results demonstrate that adipose and hepatic PPARγ are critical mediators of the beneficial effects of SCFAs on the metabolic syndrome, with clearly distinct and complementary roles. Our findings indicate that SCFAs may be used therapeutically as cheap and selective PPARγ modulators.

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Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils

Cited by 570 publications

References 46 publications

Apoptotic effect of sodium acetate on a human gastric adenocarcinoma epithelial cell line

Apoptotic effect of sodium acetate on a human gastric adenocarcinoma epithelial cell line

Induction of regulatory T cells: A role for probiotics and prebiotics to suppress autoimmunity

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

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