Suppressive effect of TRH and antidepressants on human interferon-γ productionin vitro

Abstract

Although a significant decrease in IFN-γ production was observed after joint application of TRH and antidepressants, our data did not support the above-mentioned hypothesis. Indeed, we did not observe synergistic inhibitory effects of these agents on the secretion of proinflammatory cytokines.

Effects of pentoxifylline, 7-nitroindazole, and imipramine on tumor necrosis factor-α and indoleamine 2,3-dioxygenase enzyme activity in the hippocampus and frontal cortex of chronic mild-stress-exposed rats

“…Furthermore, Kubera et al60 showed that chronic treatment with imipramine reduced immune activation in rats subjected to CMS. Additionally, imipramine inhibited the production of TNF-α in whole human blood61 and microglia and astrocyte cultures 62…”

Effects of psychotropic drugs on inflammation: consequence or mediator of therapeutic effects in psychiatric treatment?

“…Using such a strategy allows for comparison with the several meta-analyses already published on the effects of such agents on peripheral cytokine levels in vivo. We identified 17 eligible studies using antidepressants (Table 1; Xia et al 1996;Maes et al 1999;Lin et al 2000;Kubera et al 2001;Kubera et al 2002;Rudolf et al 2002;Szuster-Ciesielska et al 2003;Kubera et al 2004;Maes et al 2005;Diamond et al 2006;Carvalho et al 2008;Carvalho et al 2010;Himmerich et al 2010;Krause et al 2012;Munzer et al 2013;Tsai et al 2014;Waiskopf et al 2014) and 12 eligible studies employing antipsychotics (Table 2; Bleeker et al 1997;Leykin et al 1997;Hinze-Selch et al 1998;Moots et al 1999;Song et al 2000;Rudolf et al 2002;SzusterCiesielska et al 2004;Carvalho et al 2010;Chen et al 2011;Himmerich et al 2011;Chen et al 2013b;Krause et al 2013). …”

Eating ourselves to death (and despair): The contribution of adiposity and inflammation to depression

“…Many studies of antidepressant effects in vitro and in vivo have shown reductions in pro-inflammatory factors such as IL2, IL-6, TNFα, and IFNγ (Basterzi et al , 2005; Bengtsson et al , 1992; Kubera et al , 2000a; Kubera et al , 2000b; Kubera et al , 2000c; Kubera et al , 2001a; Kubera et al , 2001b; Lanquillon et al , 2000; Maes et al , 1999; Mohr et al , 2001; Obuchowicz et al , 2006; Seidel et al , 1995; Sluzewska et al , 1995; Song et al , 1994; Szuster-Ciesielska et al , 2003; Zhu et al , 1994; Zhu et al , 1998) (for a review, see Miller et al (Miller et al , 2009)), although the variability in the data may be accounted for a number of methodological differences (Muller and Schwarz, 2007). One study also found reductions in TNFα levels in severely depressed patients undergoing electroconvulsive therapy (Hestad et al , 2003).…”