Suppressive effect of triterpenoids and a flavonol glycoside in seaberry extract on carbacol-induced contraction of bladder smooth muscle and TGF-β-induced contraction of collagen gel containing bladder smooth muscle cells

Shimoda, Hiroshi; Takeda, Shogo; Shimizu, Norihito; Hirano, Marina; Hitoe, Shoketsu

doi:10.1016/j.jff.2017.01.043

Cited by 6 publications

(8 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Urine TGF- elevates in dysfunction of upper urinary tract [32] and is involved in hypertrophy of bladder muscle cells [33] and bladder inflammation [34]. Ursolic acid in SBE is an antagonist of TGF-1 [35] and we confirmed that ursolic acid suppressed gel contraction containing bladder smooth muscle cells induced by TGF-1 [19]. Accordingly, suppression of TGF- action by ursolic acid may be involved in the suppressive mechanism of SBE.…”

Section: Discussionsupporting

confidence: 70%

“…However, the potential health benefits of seaberry ingredients for urinary dysfunction have received little attention. Our previous in vitro study using rat bladder specimens and bladder cells demonstrated that triterpenoids derived from seaberries, including ursolic acid, suppressed excessive bladder contraction [19].…”

Section: Discussionmentioning

confidence: 96%

“…Clinical trials have demonstrated the hepatoprotective [11,12] and anti-inflammatory [13,14] effects of seaberry, in addition to its usefulness for eye care [15,16] and weight loss [17,18]. We recently found that seaberry extract (SBE) and its constituents (ursolic acid and flavonol glucoside) suppressed cholinergic bladder smooth muscle contraction in vitro [19]. Accordingly, we conducted a clinical trial to assess the effect of SBE on anxiety in Japanese subjects with moderate OAB.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Seaberry extract with ursolic acid improves anxiety about urinary dysfunction in Japanese adults

Takara¹,

Yamamoto²,

Suzuki³

et al. 2017

FFHD

Self Cite

View full text Add to dashboard Cite

Background: The seaberry is a yellow berry cultivated in China, Northern Europe, and West Asian countries. Numerous biological activities of seaberries have been reported, and we recently found that ursolic acid and a flavonoid in seaberry extract (SBE) suppressed the contraction of bladder muscle specimens and collagen gel containing bladder smooth muscle cells. However, the influence of SBE on urinary problems of Japanese adults has not been investigated. Therefore, we conducted a clinical trial of SBE supplementation in Japanese subjects with mild urinary dysfunction.Methods: We examined the effect of SBE (200 or 400 mg daily) containing ursolic acid (0.18 or 0.36 mg) in a randomized double-blind placebo-controlled study. Capsules containing SBE or placebo were administered for 8 weeks to Japanese men and women with mild urinary dysfunction. After 4 and 8 weeks of treatment, urinary symptoms were evaluated by using the King’s Health Questionnaire (KHQ) and the overactive bladder syndrome score (OABSS).Results: There was significant improvement of the KHQ emotion domain score after intake of 400 mg/day of SBE for 8 weeks compared with placebo. The answers to “Does your bladder problem make you depressed?” and “Does your bladder problem make you feel bad about yourself?” were significantly improved by SBE (400 mg/day) at 8 weeks. In the OABSS, the item “How often do you have a sudden desire to urinate, which is difficult to defer?” was significantly improved by SBE compared with placebo. Laboratory tests did not reveal any abnormalities suggesting adverse effects SBE. Conclusions: Intake of SBE (400 mg/day for 8 weeks) improved several emotional parameters related to urinary dysfunction. SBE may be useful for reducing moderate urinary symptoms.Keywords: King’s health questionnaire; overactive bladder syndrome score; seaberry; ursolic acid; overactive bladder; urination; micturition

show abstract

Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Seaberry extract with ursolic acid improves anxiety about urinary dysfunction in Japanese adults

Takara¹,

Yamamoto²,

Suzuki³

et al. 2017

FFHD

Self Cite

View full text Add to dashboard Cite

show abstract

“…These compounds are characterized by diverse biological activities (Parikh et al 2014 ; Renda et al 2021 ), and contribute to health-promoting and medicinal properties of the plant. Oleanolic acid ( 70 ) and ursolic acid ( 71 ) were probably the most frequently isolated from SB triterpenoids (Yang et al 2007 , 2013 ; Yasukawa et al 2009 ; Zheng et al 2009 ; Shimoda et al 2017 ; Redei et al 2017). Other triterpenoid compounds, purified from SB, comprise pomolic acid ( 80 ), dulcioic acid ( 72 ), corosolic acid ( 77 ), 23-hydroxyursolic acid ( 78 ), oleanolic aldehyde ( 73 ), ursolic aldehyde ( 74 ), uvaol ( 75 ), and a nortriterpenoide 28-nor-urs-12-ene-3β,17β-diol ( 81 ) (Zheng et al 2009 ; Yang et al 2013 ; Shimoda et al 2017 ).…”

Section: Phytochemistrymentioning

confidence: 99%

“…Oleanolic acid ( 70 ) and ursolic acid ( 71 ) were probably the most frequently isolated from SB triterpenoids (Yang et al 2007 , 2013 ; Yasukawa et al 2009 ; Zheng et al 2009 ; Shimoda et al 2017 ; Redei et al 2017). Other triterpenoid compounds, purified from SB, comprise pomolic acid ( 80 ), dulcioic acid ( 72 ), corosolic acid ( 77 ), 23-hydroxyursolic acid ( 78 ), oleanolic aldehyde ( 73 ), ursolic aldehyde ( 74 ), uvaol ( 75 ), and a nortriterpenoide 28-nor-urs-12-ene-3β,17β-diol ( 81 ) (Zheng et al 2009 ; Yang et al 2013 ; Shimoda et al 2017 ). Moreover, 70 , 71 , 77 , 80 , maslinic acid ( 76 ), arjunolic acid ( 79 ), betulinic acid ( 82 ), 23-hydroxybetulinic acid ( 83 ), betulin ( 84 ), and 1,2,3,19-tetrahydroxy-12-ursen-28-oic acid ( 85 ) were identified as major SB triterpenoids by LC-HRMS, with the use of authentic standards (Sun et al 2019 ; Tkacz et al 2021 ).…”

Section: Phytochemistrymentioning

confidence: 99%

Phytochemistry and pharmacology of sea buckthorn (Elaeagnus rhamnoides; syn. Hippophae rhamnoides): progress from 2010 to 2021

Żuchowski

2022

Phytochem Rev

View full text Add to dashboard Cite

Sea buckthorn (Elaeagnus rhamnoides; syn. Hippophae rhamnoides) is a thorny shrub or a small tree belonging to the Elaeagnaceae family, native to Eurasia. Sea buckthorn fruit is rich in vitamins and minerals, oils from the seeds and fruit flesh find use in medicine and the cosmetic industry or as nutraceutical supplements. Fruit, leaves and other parts of buckthorn have been used in traditional medicine, especially in China, Tibet, Mongolia, and Central Asia countries, and are a rich source of many bioactive substances. Due to its health-promoting and medicinal properties, the plant has been extensively investigated for several decades, and its phytochemical composition and pharmacological properties are well characterized. The years 2010–2021 brought significant progress in phytochemical research on sea buckthorn. Dozens of new compounds, mainly phenolics, were isolated from this plant. Numerous pharmacological studies were also performed, investigating diverse aspects of the biological activity of different extracts and natural products from sea buckthorn. This review focuses on the progress in research on sea buckthorn specialized metabolites made in this period. Pharmacological studies on sea buckthorn are also discussed. In addition, biosynthetic pathways of the main groups of these compounds have been shortly described. Graphical abstract

show abstract

Dietary Triterpenoids

Deng

Xiao

Yang

2019

Handbook of Dietary Phytochemicals

View full text Add to dashboard Cite

Suppressive effect of triterpenoids and a flavonol glycoside in seaberry extract on carbacol-induced contraction of bladder smooth muscle and TGF-β-induced contraction of collagen gel containing bladder smooth muscle cells

Cited by 6 publications

References 36 publications

Seaberry extract with ursolic acid improves anxiety about urinary dysfunction in Japanese adults

Seaberry extract with ursolic acid improves anxiety about urinary dysfunction in Japanese adults

Phytochemistry and pharmacology of sea buckthorn (Elaeagnus rhamnoides; syn. Hippophae rhamnoides): progress from 2010 to 2021

Dietary Triterpenoids

Contact Info

Product

Resources

About