2018
DOI: 10.3389/fphar.2018.00008
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Suppressive Effects of Clerodendrum volubile P Beauv. [Labiatae] Methanolic Extract and Its Fractions on Type 2 Diabetes and Its Complications

Abstract: Type 2 diabetes is the most prominent of all diabetes types, contributing to global morbidity and mortality. Availability and cost of treatment with little or no side effect especially in developing countries, remains a huge burden. This has led to the search of affordable alternative therapies especially from medicinal plants. In this study, the antidiabetic effect of the methanolic extract, dichloromethane (DCM), butanol (BuOH) and aqueous fractions of Clerodendrum volubile leaves were investigated in type 2… Show more

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Cited by 48 publications
(30 citation statements)
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“…Clerodendrum volubile is indigenous and ubiquitous to the riverine belts of the West African tropical rainforest of Nigeria, Benin Republic, Ghana, Cameroon, Burkina Faso, and Sierra Leone where it is also grown as an ornamental plant [30,31]. Due to its high nutritive and ethnopharmacological value, Clerodendrum volubile whole plant and its parts are used in the African ethnomedicine in the local management of joint pains and swellings, diabetes mellitus, gastric ulcer, obesity and hyperlipidemia, hypertension, and other heart diseases and dropsy [31,32]. However, some of these folkloric claims have been scientifically validated and have been attributed to its high polyphenol content such as ajugoside, pectolinarigenin, protocatechuic acid, biochanin, and 5, 7, 4′-trimethoxykaempferol [31].…”
Section: Introductionmentioning
confidence: 99%
“…Clerodendrum volubile is indigenous and ubiquitous to the riverine belts of the West African tropical rainforest of Nigeria, Benin Republic, Ghana, Cameroon, Burkina Faso, and Sierra Leone where it is also grown as an ornamental plant [30,31]. Due to its high nutritive and ethnopharmacological value, Clerodendrum volubile whole plant and its parts are used in the African ethnomedicine in the local management of joint pains and swellings, diabetes mellitus, gastric ulcer, obesity and hyperlipidemia, hypertension, and other heart diseases and dropsy [31,32]. However, some of these folkloric claims have been scientifically validated and have been attributed to its high polyphenol content such as ajugoside, pectolinarigenin, protocatechuic acid, biochanin, and 5, 7, 4′-trimethoxykaempferol [31].…”
Section: Introductionmentioning
confidence: 99%
“…2018). Increased production of reactive oxygen species (ROS) have been reported in extreme hyperglycemia in T2D (Erukainure et al 2018;Maritim et al 2003). Inability of the tissues' endogenous system to mop these free radicals, results in oxidative stress which has been implicated in the pathogenesis and progression of microvascular and macrovascular complications in T2D (Whitlow et al 2015).…”
Section: Introductionmentioning
confidence: 99%
“…In folklore medicine, the plant is useful for the treatment of several ailments such as diabetes, rheumatism, arthritis, edema and gout [26,27]. The reported pharmacological properties of C. volubile leaf includes anti-inflammatory [27], antioxidants [28,29], antihypertensive [25,30], antidiabetic [31,32], neuroprotective [33], hepatoprotective [34,35] and cancer chemopreventive [36,37] activities. In a recent study by Erukainure et al [38], the antidiabetic effect of acute treatment with the ethyl acetate fraction of C. volubile leaves was investigated and this property was attributed to the protocatechuic acid which was observed to be the active compound of the plant.…”
Section: Introductionmentioning
confidence: 99%
“…This plant is often termed the magic leaf owing to its wide use in folklore medicine to treat several diseases especially diabetes mellitus. Several polyphenolic compounds (flavonoids and phenolic acids) have been reported [25,29,30,32] to be present in C. volubile leaves which has been shown to confer these medicinal and health benefits of this plant.…”
Section: Introductionmentioning
confidence: 99%