Suppressive Effects of Histamine H1 Receptor Antagonist Diphenhydramine on the Leukocyte Infiltration during Endotoxin-induced Uveitis

Yamashiro, Kenji; Kiryu, Junichi; Tsujikawa, Akitaka; Nonaka, Atsushi; Honjo, Megumi; Tanihara, Hidenobu; Nishiwaki, Hirokazu; Honda, Yoshio; Ogura, Yuichiro

doi:10.1006/exer.2001.1008

Cited by 7 publications

(7 citation statements)

References 32 publications

(32 reference statements)

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“…Based on these experiments, many investigators studied agents that could suppress leukocyte-endothelial interactions in uveitis. Selectin inhibitor [109], TNF-α inhibitor [110], diphenhydramine (histamine H1 receptor) [111], and antithrombin III [112] were found to reduce leukocyte-endothelial interactions in the retinal veins in EIU rats. Hamada et al [113] reported leukocyte behavior in the retina in experimental autoimmune uveoretinitis (EAU) [114].…”

Section: Leukocyte-endothelial Interactions In Pathological Conditionsmentioning

confidence: 99%

Evaluation of Leukocyte-Endothelial Interactions in Retinal Diseases

Tsujikawa

Ogura

2011

Ophthalmologica

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Purpose: We reviewed various methodologies for studying leukocyte-retinal endothelial interactions in vivo, and summarized the information obtained from studies employing these methods. Procedures: Fluorescence dye-enhanced scanning laser ophthalmoscopy facilitates study of leukocyte-cell interactions in the retinal microcirculation. Results: Various methods such as adaptive optics scanning laser ophthalmoscopy (AO-SLO), acridine orange digital angiography, and intravital microscopy provided evidence of the mechanisms of leukocyte recruitment in the retina and of their importance in the pathogenesis of various retinal diseases. Conclusions: Leukocyte behavior can be easily examined in the retina in vivo because the optical media is transparent. SLO substantially contributes to visualizing leukocyte-endothelial interactions in retinal vessels, although most of the methods employing SLO could only be used for animal studies. AO-SLO noninvasively demonstrates the movement of each leukocyte in the parafoveal capillaries in humans. Message: AO-SLO could be useful in investigating the leukocyte-retinal endothelial interactions in various diseases in humans.

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Section: Leukocyte-endothelial Interactions In Pathological Conditionsmentioning

confidence: 99%

Evaluation of Leukocyte-Endothelial Interactions in Retinal Diseases

Tsujikawa

Ogura

2011

Ophthalmologica

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“…However, a number of patients still suffer from this complication due to alternative causes, such as allergic reactions. Although allergic reactions to pacemakers are a relatively uncommon cause of pocket effusion or hematoma, diagnosis was often postponed and/or misinterpreted as a skin infection (12,13). It was difficult to reach a diagnosis of a pacemaker allergy for several reasons, even when infection had been dismissed as the cause.…”

Section: Discussionmentioning

confidence: 99%

Clinical analysis of the effect of anti-allergy treatment on pocket-related complications following pacemaker implantation

Bai

Duan

Wang

et al. 2017

Experimental and Therapeutic Medicine

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A total number of 339 patients who received a pacemaker implantation between June 2012 and June 2014 at Tongji Hospital of Tongji Medical College (Wuhan, China) were investigated in the present study. The aims of the present study were to explore the risk factors of pocket hematoma following pacemaker implantation, and to analyze the effect of anti-allergy treatment on pocket-related complications following pacemaker implantation. Predictors of hematoma occurrence were determined and analyzed via a Chi-square test. Patients suffering from pocket hematoma, which were indicated to be partially caused by an allergic reaction to the pacemaker component, were distinguished by routine blood parameters. Furthermore, the pacemaker component was distinguished by histopathological examinations in one patient. Promethazine (25 mg/day) was used to treat allergic patients. The results demonstrated that in patients with a history of allergies, the rate of pocket hematoma was significantly higher when compared with patients without a history of allergies (22.00 vs. 7.61%; P=0.027). A significantly increased incidence of hematoma was indicated in patients with a lower body mass index when compared with patients of normal weight (15.79 vs. 7.38%; P=0.042). Furthermore, implantation of larger-sized devices, such as an implantable cardioverter-defibrillator and cardiac resynchronization therapy, were significantly predictive of hematoma development (29.63 vs. 8.01%; P=0.015). Patients with diabetes were also identified to exhibit a significantly high incidence of hematoma (22.22 vs. 8.25%; P=0.023). Promethazine administration significantly decreased the incidence of re-operating (P=0.017) and the duration of hospital stay (P=0.038) in patients whose pocket hematoma was caused by an allergy. In conclusion, promethazine may be a beneficial agent to treat pocket hematoma caused by allergic reactions following pacemaker surgery.

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“…Experimental models of these inflammations is produced by LPS injections of rats by intravenous [23], intravitreal [24] and footpad [15] administration. Since the NO overproduction by NOS II is regulated at transcriptional/translational level, the possible prevention of these inflammations may be performed by using various antiinflammatory drugs which reduce the expression of the inducible NOS II isoform.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, the use of LPS in vivo causes the induction of NOS II in retinal cells leading to retinitis and/or uveitis [9 -11, 13 , 14]. The purpose of our experiments was to study the effect of various inhibitors on NOS II induction which may result in the prevention or attenuation [15] of inflammatory diseases in the eye tissues. The selection and the doses of these inhibitors were based on previously described observations (e. g. glucocorticoids [16]), also including our results on macrophages in vitro with indomethacin [17]).…”

Section: Introductionmentioning

confidence: 99%