Suppressive Effects of JCICM-6, the Extract of an Anti-arthritic Herbal Formula, on the Experimental Inflammatory and Nociceptive Models in Rodents

Zhou, Hua; Wong, Yuen Fan; Cai, Xiong; Liu, Zhong Qiu; Jiang, Zhi Hong; Bian, Zhao Xiang; Hong, Xu; Liu, Liang

doi:10.1248/bpb.29.253

Cited by 34 publications

(27 citation statements)

References 33 publications

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“…Table 1 shows that the tail-flick reaction time of the control animals was approximately 5 s at 1, 2, and 3 h after orally taking the vehicle. Rats treated with PL did not differ from the control group, whereas rotundine, a positive analgesic agent (Zhou et al, 2006), prolonged the reaction time of the animals and demonstrated significant antinociceptive action. Fig.…”

Section: Plumbagin Inhibited Paw Edema Induced By Different Phlogistimentioning

confidence: 80%

“…The acute inflammation in the hind paws of rats was induced by subcutaneous injection of phlogistic agents, including carrageenan, histamine, serotonin, bradykinin, or PGE 2 , into the right hind paws of rats according to our previous methods (Zhou et al, 2006). In brief, two distinct schemes of treatment have been adopted.…”

Section: Methodsmentioning

confidence: 99%

“…The antinociceptive effects of PL and the reference drug, expressed as the time required for rat tail flick after exposure to a source of radiant heat, were evaluated according to the description of Zhou et al (2006). In brief, animals were placed in a Plexiglas box that allowed their tails to be free, and then the box was placed on IITC model 336 tail-flick analgesia meter (IITC Inc., Woodland Hills, CA) with the tail occluding a slit over a photocell for radiant heat stimulation generated by a power lamp mounted in a reflector.…”

Section: Methodsmentioning

confidence: 99%

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Anti-inflammatory and Analgesic Effect of Plumbagin through Inhibition of Nuclear Factor-κB Activation

Luo¹,

Wong²,

Ge³

et al. 2010

The Journal of Pharmacology and Experimental Therapeutics

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100

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Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) (PL) is a naturally occurring yellow pigment found in the plants of the Plumbaginaceae, Droseraceae, Ancistrocladaceae, and Dioncophyllaceae families. It has been reported that PL exhibits anticarcinogenic, anti-inflammatory, and analgesic activities. However, the mechanism underlying its anti-inflammatory action remains unknown. In the current study, we investigated and characterized the anti-inflammatory and analgesic effects of PL orally administrated in a range of dosages from 5 to 20 mg/kg. We also examined the role of nuclear factor B (NF-B) and proinflammatory cytokines and mediators in this effect. The results showed that PL significantly and dose-dependently suppressed the paw edema of rats induced by carrageenan and various proinflammatory mediators, including histamine, serotonin, bradykinin, and prostaglandin E 2 . PL reduced the number of writhing episodes of mice induced by the intraperitoneal injection of acetic acid, but it did not reduce the writhing episode numbers induced by MgSO 4 in mice or prolong the tail-flick reaction time of rats to noxious thermal pain. Mechanistic studies showed that PL effectively decreased the production of the proinflammatory cytokines interleukin 1␤, interleukin 6, and tumor necrosis factor ␣. It also inhibited the expression of the proinflammatory mediators inducible nitricoxide synthase and cyclooxygenase 2, whereas it did not inhibit the expression of cyclooxygenase 1. Further studies demonstrated that PL suppressed inhibitor of B␣ phosphorylation and degradation, thus inhibiting the phosphorylation of the p65 subunit of NF-B. This study suggests that PL has a potential to be developed into an anti-inflammatory agent for treating inflammatory diseases.

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Section: Plumbagin Inhibited Paw Edema Induced By Different Phlogistimentioning

confidence: 80%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Anti-inflammatory and Analgesic Effect of Plumbagin through Inhibition of Nuclear Factor-κB Activation

Luo¹,

Wong²,

Ge³

et al. 2010

The Journal of Pharmacology and Experimental Therapeutics

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100

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“…Acute infl ammation observed in both phases leads to leakage of plasma elements from blood vessels to the infl amed tissue, and the infi ltration of neutrophils. 23,24 Histamine, serotonin, bradykinin, PGs, hydrogen sulfi de, and nitric oxide are some of the infl ammatory mediators which play a role in this model. 22 It was noticed in the current study that BIRM administration signifi cantly reduced the carrageenan-induced paw edema at all-time points of the study.…”

Section: Discussionmentioning

confidence: 99%

Investigation of centrally and peripherally acting analgesic and anti-inflammatory activity of BIRM (An Amazonian plant extract) in animal models of pain and inflammation

Ravalji

Cevallos-Arellano²,

Balakrishnan

2015

Int J Basic Clin Pharmacol

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“…injection is an experimental model used for determining the central and peripheral analgesic activity of drugs [16]. In addition, a good relationship exists between the potencies of analgesics in writhing test and their clinical potencies [17]. AA was shown to increase levels of pain mediators, such as prostaglandin E2 (PGE 2 ), PGF 2 α, serotonin, and histamine, in peritoneal fluids [18] followed by induction of writhing response, including contraction of abdominal muscles, extension of the forelimbs, and elongation of the body [19].…”

Section: Analgesic Effects Of Hme In Hot-plate Test and In Aa-inducedmentioning

confidence: 99%

Analgesic and Anti-Inflammatory Effects of Herbal Mixture Extracts in Mice

Chien¹,

Chuang²,

Lin³

et al. 2018

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Herbal mixture extracts (HME) comprised of Semen Sojae Nigrum, Fructus Cnidii, Radix Glycyrrhizae, and Cornu Cervi. Herein, we employed three mouse models, including hot-plate test, acetic acid (AA)-induced writhing test and AA-induced vascular permeability test, to determine analgesic and anti-inflammatory effects of HME. Results revealed that HME exhibited analgesic effects in hot-plate test and in AA-induced writhing test, as evidenced by increasing the latency to lick paws and decreasing AA-induced writhing counts, respectively. HME also significantly and dose-dependently decreased AA-induced vascular permeability, indicating HME exhibited anti-inflammatory effects. Similar improvement can be observed in aspirin treatment that used as positive control in this study. Most of medicinal effects of Fructus Cnidii are considered to attribute to coumarins, such as osthol (OST) and imperatorin (IMP) with several pharmacological activities. We then used OST and IMP as bioactive components in HME. The content of OST and IMP in HME was 3.57 ± 0.10 mg/g and 1.20 ± 0.02 mg/g, respectively, from three independent batches. Only OST possessed inhibitory effects in three mouse models, suggesting that OST may partially involve in protective effects of HME. These results demonstrated that HME has a potential on anti-analgesic effects and anti-inflammatory actions.

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Suppressive Effects of JCICM-6, the Extract of an Anti-arthritic Herbal Formula, on the Experimental Inflammatory and Nociceptive Models in Rodents

Cited by 34 publications

References 33 publications

Anti-inflammatory and Analgesic Effect of Plumbagin through Inhibition of Nuclear Factor-κB Activation

Anti-inflammatory and Analgesic Effect of Plumbagin through Inhibition of Nuclear Factor-κB Activation

Investigation of centrally and peripherally acting analgesic and anti-inflammatory activity of BIRM (An Amazonian plant extract) in animal models of pain and inflammation

Analgesic and Anti-Inflammatory Effects of Herbal Mixture Extracts in Mice

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