Suppressive effects of the marine carotenoids, fucoxanthin and fucoxanthinol on triglyceride absorption in lymph duct-cannulated rats

Matsumoto, Megumi; Hosokawa, Masashi; Matsukawa, Noriko; Hagio, Masahito; Shinoki, Aki; Nishimukai, Megumi; Miyashita, Kazuo; Yajima, Takaji; Hara, Hiroshi

doi:10.1007/s00394-009-0078-y

Cited by 111 publications

(56 citation statements)

References 25 publications

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“…The volume temporally decreased after the infusion of methyl mercury. Matsumoto et al [31] also observed a reduction of the flow rate of lymph within 1 h after the infusion of organic components. Although the substance differs from the present study, the same phenomenon may occur.…”

Section: Resultsmentioning

confidence: 91%

Direct Absorption of Methyl Mercury by Lymph

Murota

Yoshida

Ishibashi

et al. 2011

Biol Trace Elem Res

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Methyl mercury is contained in fish and seafood products and is taken up into the body in food. While the central nervous system is known as a target organ, methyl mercury also induces autoimmunity and acts as a potent immunosuppressor. The aim of the present study is to know whether methyl mercury is directly absorbed by lymph. Conscious rats were infused with methyl mercury (4 mg/kg) via duodenal tubing as a single pulse infusion, followed by the continuous infusion of saline, and lymphatic fluids were continuously collected from the thoracic lymph duct every 30 min until 360 min after infusion. Mercury was detected immediately after infusion, and total mercury contents in lymph gradually increased until 90-120 min, remained steady, and then gradually decreased until 360 min; however, the amount of mercury collected during 330-360 min was about twofold higher than during 0-30 min. The amount of cumulative mercury in lymph at 360 min was 1.4 μg. In contrast, blood mercury concentration was 2.4 μg/ml 5 min after infusion, with the value at 360 min being 12.6 times higher than at 5 min. Plasma mercury concentration was 56 ng/ml at 5 min, with hundreds of nanograms per milliliter of mercury detected until 360 min. From the present study, it is concluded that some methyl mercury is directly absorbed by lymph and remains steady 6 h after infusion.

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Section: Resultsmentioning

confidence: 91%

Direct Absorption of Methyl Mercury by Lymph

Murota

Yoshida

Ishibashi

et al. 2011

Biol Trace Elem Res

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“…Additionally, the concentration of chitosan in the shrimp residue extracts from the present work is probably low due to the characteristics of the extraction procedures applied (SOX and SFE), which were not appropriated for polysaccharide extraction. Still, fucoxanthin, a carotenoid from xanthophyll group and structurally similar to astaxanthin, has been indicated to reduce the obesity by inhibiting the intestinal lipase activity [51], which may also reduce the plasma triglycerides levels. Moore et al [52] studied the influence of oily fish intake on plasma triacylglycerols from overweight men and women and the results indicated that two portions of oily fish, rich in DHA and EPA, per week led to significant reduction in triglycerides levels, compared to consumption of the same portion of white fish that do not presented significant content of these fatty acids.…”

Section: Anti-obesity and Hypolipidemic Effectsmentioning

confidence: 99%

Evidence of anti-obesity and mixed hypolipidemic effects of extracts from pink shrimp (Penaeus brasiliensis and Penaeus paulensis) processing residue

Mezzomo

Tenfen

Farias

et al. 2015

The Journal of Supercritical Fluids

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“…Fucoxanthin isolated from edible seaweeds, and its metabolite fucoxanthinol, have been shown to inhibit pancreatic lipase activity in the gastrointestinal lumen and leading to suppressed triacylglycerol absorption in lymph-duct cannulated rats [32]. In addition, fucoxanthin and fucoxanthinol were found to significantly inhibit pancreatic lipase activity, assayed based on inhibition of the hydrolysis of triolein.…”

Section: Marine Algae As a Source Of Anti-pancreatic Lipase Agentsmentioning

confidence: 99%

Marine Algae as a Potential Source for Anti-Obesity Agents

2016

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Obesity is a major epidemic that poses a worldwide threat to human health, as it is also associated with metabolic syndrome, type 2 diabetes and cardiovascular disease. Therapeutic intervention through weight loss drugs, accompanied by diet and exercise, is one of the options for the treatment and management of obesity. However, the only approved anti-obesity drug currently available in the market is orlistat, a synthetic inhibitor of pancreatic lipase. Other anti-obesity drugs are still being evaluated at different stages of clinical trials, while some have been withdrawn due to their severe adverse effects. Thus, there is a need to look for new anti-obesity agents, especially from biological sources. Marine algae, especially seaweeds are a promising source of anti-obesity agents. Four major bioactive compounds from seaweeds which have the potential as anti-obesity agents are fucoxanthin, alginates, fucoidans and phlorotannins. The anti-obesity effects of such compounds are due to several mechanisms, which include the inhibition of lipid absorption and metabolism (e.g., fucoxanthin and fucoidans), effect on satiety feeling (e.g., alginates), and inhibition of adipocyte differentiation (e.g., fucoxanthin). Further studies, especially testing bioactive compounds in long-term human trials are required before any new anti-obesity drugs based on algal products can be developed.

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Suppressive effects of the marine carotenoids, fucoxanthin and fucoxanthinol on triglyceride absorption in lymph duct-cannulated rats

Abstract: These results show that these two marine carotenoids inhibit lipase activity in the gastrointestinal lumen and suppress triglyceride absorption, and fucoxanthin was converted to fucoxanthinol in the intestine and released into the lymph.

Cited by 111 publications

References 25 publications

Direct Absorption of Methyl Mercury by Lymph

Direct Absorption of Methyl Mercury by Lymph

Evidence of anti-obesity and mixed hypolipidemic effects of extracts from pink shrimp (Penaeus brasiliensis and Penaeus paulensis) processing residue

Marine Algae as a Potential Source for Anti-Obesity Agents

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