Suppressor-Cell Dysfunction in Systemic Lupus Erythematosus

Sagawa, Akira; Abdou, Nabih I.

doi:10.1172/jci109190

Cited by 141 publications

(40 citation statements)

References 26 publications

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“…Earlier studies demonstrated that patients with active SLE had a loss of suppressor T lymphocyte function (22)(23)(24)(25)(26)(27)(28). Several studies have emphasized the importance of anti-T cell antibodies in altering T cell number and function in patients with active SLE (7,8,(28)(29)(30)(31)(32)(33)(34).…”

Section: Discussionmentioning

confidence: 99%

Autoantibody to an Immunoregulatory Inducer Population in Patients with Juvenile Rheumatoid Arthritis

Morimoto¹,

Reinherz²,

Borel³

et al. 1981

J. Clin. Invest.

109

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A B S T R A C T The human inducer (T4+) and reciprocal cytotoxic/suppressor (T5+/T8+) subsets have been defined by monoclonal antibodies. In the present study, we examined the relationship of naturally occurringanti-T cell autoantibodies found in patients with active juvenile rheumatoid arthritis (JRA) to these subsets. In one approach, normal T cells were treated with anti-T4 or anti-T8 to eliminate the corresponding subset of cells and then analyzed for reactivity with JRA sera. It was found that JRA sera were reactive with only 15% of an enriched cytotoxic/suppressor population, whereas they reacted with 37% of an enriched inducer population. In reciprocal studies, JRA+ T cells were eliminated with JRA sera and complement and the residual T cells (JRA-) reacted with monoclonal antibodies and indirect immunofluorescence on a fluorescence-activated cell sorter. As expected, the JRA sera and complement treatment of unfractionated T cells markedly diminished the T4+ subset, whereas there was a concomitant increase in T cells reactive with anti-T5 and anti-T8. A similar diminution in T4+ T cells was found in the circulating peripheral T cell compartment of patients with active JRA who possessed the JRA antibody.Functional studies demonstrated that removal of the JRA+ population of T cells diminished phytohemagglutinin and soluble antigen proliferative responses,

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Section: Discussionmentioning

confidence: 99%

Autoantibody to an Immunoregulatory Inducer Population in Patients with Juvenile Rheumatoid Arthritis

Morimoto¹,

Reinherz²,

Borel³

et al. 1981

J. Clin. Invest.

109

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“…These studies have used different methods both for the induction of the suppressor cell activity in vitro as well as for the detection and quantitation of suppressor function. Indeed, not all of these reports have dealt with the suppression of T cells on B cells (1,(4)(5)(6)(7)9) or studied its effect on immuno- …”

mentioning

confidence: 99%

“…globulin secreting cells or immunoglobulin production (1,(5)(6)(7)9). An alteration of T cell suppression on immunoglobulin secretion may explain the production of autoantibodies, a characteristic of SLE.…”

mentioning

confidence: 99%

Heterogeneity of the spontaneously expanded and mitogen‐induced generation of suppressor cell function of t cells on b cells in systemic lupus erythematosus

Ruı́z-Argüelles¹,

Alarcón‐Segovia²,

Llórente³

et al. 1980

Arthritis & Rheumatism

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Several studies have shown that there is decreased suppressor cell function in systemic lupus erythematosus (SLE) (1-9). These studies have used different methods both for the induction of the suppressor cell activity in vitro as well as for the detection and quantitation of suppressor function. Indeed, not all of these reports have dealt with the suppression of T cells on B cells (1,(4)(5)(6)(7)9) or studied its effect on immuno-

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“…The suppression was no different from that (23,24) as well as T-cell subsets determined by a number of other methodologies (25)(26)(27)(28)(29). This is of particular relevance in light of the fact that in several in vitro systems, SLE has been demonstrated to manifest a deficiency of suppressor cell function (23,(30)(31)(32)(33)(34)(35). Although the actual suppressor cell in most of these systems has not been conclusively identified, at least in some systems of in vitro B-cell function, the TG cell has been demonstrated to be the suppressor cell (16).…”

Section: Resultsmentioning

confidence: 66%