Suppressor factor produced by neonatal mouse spleen cells

Argyris, Bertie F.

doi:10.1016/0008-8749(81)90342-7

Cited by 24 publications

(8 citation statements)

References 43 publications

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“…Also presented in this study are data that reveal thai the newborn spleen-associated suppressor monocyte population effects suppression not only of the proliferation of T cells but also of the subsequent dillcreniiation of CTLs through production of soluble factors. The fact that neonate spleen ceils produce inhibitory factors in culture is in complete agreement with the earlier stLidics of Basset et al [4] and Argyris [3]. Although the precise nature of this suppressor material remains unknown, two separate reports might suggest that the immime reactivity is being tnodulated by production of prostaglandins.…”

Section: Discussionsupporting

confidence: 88%

Isolation and Identification of the Naturally Occurring, Newborn Spleen‐Associated Suppressor Cells

1983

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Spleens from newborn mice less than 6-7 days of age contain 'naturally occurring' suppressor cell populations that are able to inhibit nonspecifically immune responses of third-party adult spleen cells and alloreactivity in the newborn spleen per se. Isolation of the effectors of this suppressor activity reveals that they are not classical T lymphocytes but, instead, a mixed population of cells of the monocyte series (monoblast/promonocyte/monocyte) plus mast cells. This mixed population apparently can elicit its suppressor activity in part through secretion of soluble, in vitro culture-stable material, which in turn initiates activation of the suppressor cell/limb of the immune response. These activities, nevertheless, modulate most strongly the early activation events of T-cell responses and can result in complete suppression of alloreactive helper and cytotoxic T lymphocyte development. Suppressor activity by mast cells can be demonstrated by degranulation, whereas suppressor activity by monocytes appears inherent in the newborn population. Thus, there are now at least three cell populations in the neonate spleen--mast cells, monocytes, and T lymphocytes--which can effect suppressor activity.

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Section: Discussionsupporting

confidence: 88%

Isolation and Identification of the Naturally Occurring, Newborn Spleen‐Associated Suppressor Cells

1983

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“…The understanding of MDSC development in tumor models provides an important means by which to control undesirable immune responses against transplant allografts. Bertie Argyris isolated a “suppressor factor” secreted from the spleen cells of tumor-bearing mice that was able to prolong skin allograft survival [5, 6]. More recently, Vinvenzo Bronte and our laboratory reported that adoptive transfer of MDSC was able to induce tolerance to autoimmune T cells against islet antigen, islet allograft and prevent graft versus host disease in bone marrow-transplanted mice [50, 73, 93].…”

Section: Final Remarksmentioning

confidence: 99%

“…Since MDSC are in part responsible for protecting tumors against rejection despite the recognition of tumor-associated antigens, we hypothesize that a better understanding of the immunologic mechanisms of tumor acceptance mediated by MDSC can provide critical information to prevent allograft rejection in transplantation. Indeed, Argyris [5, 6] suggested that spleen cells from tumor-bearing mice secreted a “suppressor factor,” which could be used to prolong skin allograft survival. Further, Muller and colleagues prolonged graft survival by transferring spleen cells from tumor-bearing mice into skin transplant recipients [7].…”

Section: Introductionmentioning

confidence: 99%

Myeloid-derived suppressor cells in transplantation and cancer

Ochando

Chen

2012

Immunol Res

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Myeloid-derived suppressor cells (MDSC) are myeloid cells that suppress the immune response, a definition that reflects both their origin and their function. As negative regulators of the immune response, MDSC represent a novel therapeutic approach for manipulating the immune system toward tolerance or immunity. MDSC are present in cancer patients and tumor-bearing mice and are in part responsible for the inhibition of the cell-mediated immune response against the tumor. Our laboratories investigate the immunologic mechanisms of tumor acceptance mediated by MDSC, which can be exploited to prevent allograft rejection in transplantation. A better understanding of MDSC biology will open new avenues for therapeutic intervention, either by inhibiting their function (i.e. in cancer patients), or by enhancing their suppressive effects and promoting their expansion (i.e. in organ transplantation and alloimmune responses). In this review, we summarize some of the critical aspects of the immunoregulatory function of MDSC in cancer and transplantation and discuss their potential clinical applications.

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“…Cells mediating such spontaneous cytolytic activity belong to the innate, non-adaptive immune system, and are referred to as natural killer (NK) cells -cells that have been recognized for decades as belonging to the "first line of defense" in tumor combat (Herberman et al, 1975;Keissling andWigzell, 1979: Riccardi et al, 1981;Miller, 1982). However, pre-weaned mice under the age of 4 weeks, show little or no NK-cell-mediated, anti-tumor activity (Argyris, 1981;Maier et al, 1989;Dussault and Miller, 1993), paralleling the immaturity in other cell lineages in the immune system, i.e., T, B lymphocytes, responsible for adaptive immune responses. In humans, such immaturity in the infant/juvenile NK cell-mediate immunity specifically, may be more than coincidentally concomitant with the relatively high frequency of leukemias and lymphomas in the pediatric population, especially prevalent in children with Down's Syndrome (Fong and Brodeur, 1987;Ross et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Dietary Supplementation with an Extract of North American Ginseng in Adult and Juvenile Mice Increases Natural Killer Cells

Miller

Shan³

2011

Immunological Investigations

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Cells belonging to the innate immune system are referred to as natural killer (NK) cells. We recently demonstrated that normal, pre-weaned infant mice, injected with a proprietary extract of ginseng (CVT-E002) had augmented NK cell numbers vs. sham-injected mice. In the present study, we extended these observations into juvenile and adult mice. Thus, young adult (age: 8-9 wk) C3H mice were given daily dietary CVT-E002 for 4 wk followed by untreated chow for the following 2 months, then euthanized (age: 20-21 wk). Other C3H mice (juvenile: 4-wk-old) were given CVT-E002 under the same protocol and sampled at 18 wk of age. In spite of withdrawing the extract 2 months earlier, the absolute numbers of NK cells in the young adults, remained significantly (p < 0.01), and slightly, elevated in the spleen and bone marrow (BM), respectively. The relative numbers (%) of NK cells in the blood also remained elevated (p < 0.05). In juvenile mice fed CVT-E002, the absolute numbers (spleen, BM) and % (blood) of NK cells were all elevated (p<0.01 - p<0.05). The mechanisms responsible for these super-normal numbers of NK cells long after withdrawal of CVT-E002, is as yet unknown.

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Suppressor factor produced by neonatal mouse spleen cells

Cited by 24 publications

References 43 publications

Isolation and Identification of the Naturally Occurring, Newborn Spleen‐Associated Suppressor Cells

Isolation and Identification of the Naturally Occurring, Newborn Spleen‐Associated Suppressor Cells

Myeloid-derived suppressor cells in transplantation and cancer

Dietary Supplementation with an Extract of North American Ginseng in Adult and Juvenile Mice Increases Natural Killer Cells

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