Suppressor of cytokine signaling 2 (SOCS-2) homologue in disk abalone: Cloning, sequence characterization and expression analysis

The construction of a cDNA library enriched for immune genes and the analysis of 7535 ESTs from Chinese mitten crab Eriocheir sinensis

“…Recently, several SOCSs have been found in the invertebrates honey bee Apis mellifera [64], mosquito Anopheles gambiae and abalone Haliotis discus discus [64]. After Mycobacterium bovis, Vibrio alginolyticus, Vibrio parahemolyticus, and Listeria monocytogenes challenge, the mRNA expressions of invertebrate SOCSs were induced significantly [64]. The identification of immune inducible VEGF and SOCS in the present study was probably the reflection of the effect of injected bacteria on E. sinensis.…”

“…Accumulative data indicated that human VEGF was an inducible gene, and could be induced by bacterial lipopolysaccharide and peptidoglycan [62,63]. To control the excessive cytokine effects, cytokine signaling is negatively regulated by SOCS [64]. Recently, several SOCSs have been found in the invertebrates honey bee Apis mellifera [64], mosquito Anopheles gambiae and abalone Haliotis discus discus [64].…”

“…To control the excessive cytokine effects, cytokine signaling is negatively regulated by SOCS [64]. Recently, several SOCSs have been found in the invertebrates honey bee Apis mellifera [64], mosquito Anopheles gambiae and abalone Haliotis discus discus [64]. After Mycobacterium bovis, Vibrio alginolyticus, Vibrio parahemolyticus, and Listeria monocytogenes challenge, the mRNA expressions of invertebrate SOCSs were induced significantly [64].…”

Tumor suppressor QM-like gene from disk abalone (Haliotis discus discus): Molecular characterization and transcriptional analysis upon immune challenge

“…The gill is a nonimmune organ in mollusks, but it is closely related with immune responses. Recent studies have shown that a variety of immune-, inflammatory-and apoptosis-related genes, such as Mx [31], TNF [32], Fas ligand [33], and SOCS-2 [34], are expressed and regulated in gills, reflecting its role in host defense. For this reason, we selected gill as additional tissue to analyze the transcriptional regulation of AbQM.…”

Microarray analysis of gene expression in disk abalone Haliotis discus discus after bacterial challenge

“…On the other hand, activation of cytokine-related transcripts could be correlated with the considerably higher SOCS-2 expression detected in this study, since the excessive cytokine production is controlled by SOCS family proteins. Similarly, activation of SOCS-2 in bacteria-challenged abalone has been described previously [15,21].…”