Suppressor of Hairless Is Required for Long-Term Memory Formation in Drosophila

Song, Qingxuan; Shuai, Yichun; Lin, Rongcheng; You, Wenjia; Wang, Lianzhang; Zhong, Yi

doi:10.1080/01677060903096133

Cited by 4 publications

(4 citation statements)

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“…The first contained eight genes, mostly all upregulated in older workers, associated with the regulation of Notch signaling and signal transduction, including mind bomb 1 ( mib1 ), deltex ( dx ) and aristaless ( al ). Recent studies on Drosophila have shown the importance of Notch signaling in the process of long‐term memory (Ge et al 2004; Matsuno et al 2009; Song et al 2009), and Notch signaling is also involved in spatial learning and memory in mammals (Yoon & Gaiano 2005). Our results are particularly intriguing because foragers must develop a map‐like spatial memory to learn and communicate the location of profitable flowers relative to the hive (Menzel et al 2005), and the transition from nursing to foraging involves an expansion in parts of the brain implicated in learning and memory, the mushroom bodies (Withers et al 1993).…”

Section: Discussionmentioning

confidence: 99%

Common and novel transcriptional routes to behavioral maturation in worker and male honey bees

Zayed

Naeger²,

Rodríguez-Zas³

et al. 2011

Genes Brain and Behavior

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Worker honey bees (Apis mellifera) undergo a process of behavioral maturation leading to their transition from in-hive tasks to foraging -a process which is associated with profound transcriptional changes in the brain. Changes in brain gene expression observed during worker behavioral maturation could represent either a derived program underlying division of labor or a general program unrelated to sociality. Male bees (drones) undergo a process of behavioral maturation associated with the onset of mating flights, but do not partake in division of labor. Drones thus provide an excellent reference point for polarizing transcriptional changes associated with behavioral maturation in honey bees. We assayed the brain transcriptomes of adult drones and workers to compare and contrast differences associated with behavioral maturation in the two sexes. Both behavioral maturation and sex were associated with changes in expression of thousands of genes in the brain. Many genes involved in neuronal development, behavior, and the biosynthesis of neurotransmitters regulating the perception of reward showed sexbiased gene expression. Furthermore, most of the transcriptional changes associated with behavioral maturation were common to drones and workers, consistent with common genetic and physiological regulation. Our study suggests that there is a common behavioral maturation program that has been co-opted and modified to yield the different behavioral and cognitive phenotypes of worker and drone bees.

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Section: Discussionmentioning

confidence: 99%

Common and novel transcriptional routes to behavioral maturation in worker and male honey bees

Zayed

Naeger²,

Rodríguez-Zas³

et al. 2011

Genes Brain and Behavior

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“…Interestingly, these three genes are all involved in the Notch signaling pathway (Oishi et al, 2004;Kosik, 2006;Orian et al, 2007). Moreover, c-myc and Bcl-2 regulate neurogenesis in Drosophila (Preiss et al, 1988;Orian et al, 2007), and Notch signaling is critical for the formation of long-term memory in the Drosophila MBs (Ge et al, 2004;Song et al, 2009). These microRNAs might be involved in synaptic plasticity and/or neurogenesis via the Notch signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

Expression of two microRNAs, ame-mir-276 and -1000, in the adult honeybee (Apis mellifera) brain

et al. 2011

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-To identify candidate microRNAs involved in post-transcriptional regulation of brain (region)-selective gene expression in the adult honeybee brain, we isolated eight microRNAs: seven known microRNAs, ame-mir-2-1, -8, 13a, -34, -276, -317, -1000, and one novel one, named mir-hbd, that has significant sequence similarity with the Drosophila dme-mir-11. Among them, ame-mir-1000 and -276 were expressed in a brain-selective and -preferential manner, respectively, in workers and drones. In particular, ame-mir-276-expression was enriched in the optic lobes and in the small type-Kenyon cells of the mushroom bodies in the nurse bee, forager, queen, and drone brains. Almost all predicted targets of amemir-1000 and -276 encode neural function related genes, suggesting the involvement in neural function of both microRNAs.brain / microRNA / Apis mellifera / honey bee / gene expression

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“…Early work has indicated that RBPJK 1/2 mice display a milder but significant spatial memory acquisition defect as compared to Notch1 1/2 (Costa et al, 2005). A more recent study, in Drosophila, attributes to the homolog of RBPJK, Su(H), the same properties as Notch in long-term memory (Song et al, 2009). In contrast, a subsequent work in mice has indicated that the loss of RBPJK in mature excitatory networks does not recapitulate the effect of Notch1 loss of function in spatial memory (Sato et al, 2012).…”

Section: Notch Signaling In Memory and Animal Behaviormentioning

confidence: 99%

Notch in memories: Points to remember

Marathe

Albèri

2015

Hippocampus

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Memory is a temporally evolving molecular and structural process, which involves changes from local synapses to complex neural networks. There is increasing evidence for an involvement of developmental pathways in regulating synaptic communication in the adult nervous system. Notch signaling has been implicated in memory formation in a variety of species. Nevertheless, the mechanism of Notch underlying memory consolidation remains poorly understood. In this commentary, besides offering an overview of the advances in the field of Notch in memory, we highlight some of the weaknesses of the studies and attempt to cast light on the apparent discrepancies on the role of Notch in memory. We believe that future studies, employing high-throughput technologies and targeted Notch loss and gain of function animal models, will reveal the mechanisms of Notch dependent plasticity and resolve whether this signaling pathway is implicated in the cognitive deficit associated with dementia. V C 2015Wiley Periodicals, Inc.

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Suppressor of Hairless Is Required for Long-Term Memory Formation in Drosophila

Cited by 4 publications

References 0 publications

Common and novel transcriptional routes to behavioral maturation in worker and male honey bees

Common and novel transcriptional routes to behavioral maturation in worker and male honey bees

Expression of two microRNAs, ame-mir-276 and -1000, in the adult honeybee (Apis mellifera) brain

Notch in memories: Points to remember

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