Suppressor PAQR3 associated with the clinical significance and prognosis in esophageal squamous cell carcinoma

Bai, Ge; Yang, Minghui; Zheng, Chao; Zhang, Li; Eli, Mayinur

doi:10.3892/ol.2018.8004

Cited by 6 publications

(13 citation statements)

References 22 publications

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“…[4–18] However, others found that there were no relationships between tumor length and oncological outcomes in EC patients. [19–23] Therefore, the prognostic significance of tumor length remains controversial. Because an individual study is likely to provide a biased result that may partly result from the small sample size, we conducted a systematic review and quantitative meta-analysis to comprehensively assess the prognostic significance of tumor length in EC patients.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of tumor length in patients with esophageal cancer undergoing radical resection

Yang¹,

Liu

Li³

et al. 2019

Medicine

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Background: The prognostic significance of tumor length in esophageal cancer (EC) remains controversial. Hence, we conducted a meta-analysis to quantitatively assess the prognostic significance of tumor length in EC patients. Method: A systematic literature search was conducted in the PubMed, EMBASE, and Web of Science. Hazard ratios (HRs) with their 95% confidence intervals (CIs) were used to assess the prognostic significance of tumor length for overall survival (OS), and disease-free survival (DFS) in EC patients. Results: A total of 21 articles with 22 eligible studies involving 9271 patients were included in this meta-analysis. The results of our pooling analyses demonstrated that tumor length was an independent prognostic parameter for OS (HR = 1.38, 95% CI: 1.24–1.54, P < .01) and DFS (HR = 1.29, 95% CI: 1.11–1.50, P < .01) in EC patients. Moreover, our subgroup analysis and sensitivity analysis showed that the pooled HRs assessing the prognostic significance of tumor length did not significantly fluctuated, suggesting our pooling analyses were stable and reliable. Conclusion: The results of this meta-analysis demonstrated that long tumor is an independent risk of poor OS and DFS in EC patients, suggesting that it may provide additional prognostic information and thus contribute to a better stratification of EC patients, especially for those with no lymph node metastasis. However, more well-designed prospective clinical studies with large sample size are needed to strength our conclusion due to several limitations in this meta-analysis.

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Section: Introductionmentioning

confidence: 99%

Prognostic significance of tumor length in patients with esophageal cancer undergoing radical resection

Yang¹,

Liu

Li³

et al. 2019

Medicine

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“…In addition, the expression of PAQR3 in esophageal cancer tissues is lower than that in normal esophageal tissues, and is significantly correlated with tumor size, lymph node metastasis, and local recurrence among esophageal cancer patients. In addition, it inhibits the proliferation, cell cycle, clone formation, migration, and invasion of esophageal cancer cells, as confirmed in a nude mouse xenograft model ( Zhou et al, 2017 ; Bai et al, 2017 , 2018 ). In addition, PAQR3 expression is decreased in some other tumors such as osteosarcoma, gastric cancer, and breast cancer, and the functions in these tumor tissues are consistent with those mentioned above, and include the inhibition of the growth and migration of tumor cells ( Ling et al, 2014 ; Li et al, 2015 ; Ma et al, 2015 ; Zhao et al, 2017 ).…”

Section: Introductionmentioning

confidence: 71%

“…The level of PAQR3 was decreased both in tissues and cells of esophageal cancer, and overexpression of PAQR3 significantly inhibited the proliferation, clone formation, and invasion of esophageal cancer cells and blocked the transition from the G1 phase to the S phase. Moreover, increased PAQR3 expression inhibited the growth of ECA-109 cell xenograft tumors ( Zhou et al, 2017 ; Bai et al, 2017 , 2018 ). Compared with adjacent tissues, the expression of PAQR3 in laryngeal squamous cell carcinoma (LSCC) tissues was significantly downregulated, and overexpression of PAQR3 inhibited the proliferation and invasion of LSCC cells ( Wu et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

PAQR3 Inhibits Non-small Cell Lung Cancer Growth by Regulating the NF-κB/p53/Bax Axis

Guo

Fang

et al. 2020

Front. Cell Dev. Biol.

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Background The expression of progestin and adipoQ receptor 3 (PAQR3) is generally downregulated in multiple tumors, which is associated with tumor progression and poor prognosis. Methods The clinical value of PAQR3 was analyzed using various databases and in 60 patients with non-small cell lung cancer (NSCLC). In addition, cell counting kit-8 (CCK-8), colony formation, and flow cytometry assays were used to evaluate the effect of PAQR3 on the growth of NSCLC cells in vitro . Gene set enrichment analysis (GSEA) was performed to investigate the possible mechanism through which PAQR3 is involved in the progression of lung cancer. Furthermore, western blotting was employed to verify the relevant mechanism. Results The expression of PAQR3 was decreased in 60 NSCLC patients and was related to the histological subtype, lymph node metastasis, tumor size, and diagnosis of NSCLC. Patients with lung adenocarcinoma with increased PAQR3 expression tended to have a better prognosis. Besides, PAQR3 inhibited proliferation, clone formation, and cycle transition in NSCLC cells, but induced apoptosis. The results of GSEA showed that PAQR3 regulated the progression of lung cancer by affecting cell cycle, DNA replication, and the p53 signaling pathway. We confirmed that PAQR3 overexpression inhibited the expression of NF-κB, while it increased the expression of p53, phospho-p53, and Bax. On the contrary, PAQR3 inhibition played an opposite role in these proteins. Conclusion PAQR3 inhibited the growth of NSCLC cells through the NF-κB/P53/Bax signaling pathway and might be a new target for diagnosis and treatment.

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“…Mechanistically, overexpression of PAQR3 suppressed the ERK pathway. 43,44 And, it was found that PAQR3 is lowly expressed in human ESCC cell lines. PAQR3 overexpression was shown to reduce malignant potential in cultured ESCC cells and attenuated the growth of xenografted tumors.…”

Section: Esophageal Squamous Cell Carcinoma Cellsmentioning

confidence: 99%

“…45 Jointly, the above findings demonstrated PAQR3 overexpression suppresses the aggressive phenotype of ESCC cells in culture and animals, indicating PAQR3 could be targeted for ESCC treatment. [43][44][45] Gastric cancer…”

Section: Esophageal Squamous Cell Carcinoma Cellsmentioning

confidence: 99%

<p>Characterization of the Golgi scaffold protein PAQR3, and its role in tumor suppression and metabolic pathway compartmentalization</p>

Lan

Ling

Chen

et al. 2020

CMAR

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The Golgi apparatus is critical in the compartmentalization of signaling cascades originating from the cytoplasmic membrane and various organelles. Scaffold proteins, such as progestin and adipoQ receptor (PAQR)3, specifically regulate this process, and have recently been identified in the Golgi apparatus. PAQR3 belongs to the PAQR family, and was recently described as a tumor suppressor. Accumulating evidence demonstrates PAQR3 is downregulated in different cancers to suppress its inhibitory effects on malignant potential. PAQR3 functions biologically through the pathological regulation of altered signaling pathways. Significant cell proliferation networks, including Ras proto-oncogene (Ras)/mitogenactivated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), insulin, and vascular endothelial growth factor, are closely controlled by PAQR3 for physiologically relevant effects. Meanwhile, genetic/epigenetic susceptibility and environmental factors, may have functions in the downregulation of PAQR3 in human cancers. This study aimed to assess the subcellular localization of PAQR3 and determine its topological features and functional domains, summarizing its effects on cell signaling compartmentalization. The pathophysiological functions of PAQR3 in cancer pathogenesis, metabolic diseases, and developmental ailments were also highlighted.

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Suppressor PAQR3 associated with the clinical significance and prognosis in esophageal squamous cell carcinoma

Cited by 6 publications

References 22 publications

Prognostic significance of tumor length in patients with esophageal cancer undergoing radical resection

Prognostic significance of tumor length in patients with esophageal cancer undergoing radical resection

PAQR3 Inhibits Non-small Cell Lung Cancer Growth by Regulating the NF-κB/p53/Bax Axis

<p>Characterization of the Golgi scaffold protein PAQR3, and its role in tumor suppression and metabolic pathway compartmentalization</p>

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