Supra-alveolar bone regeneration: Progress, challenges, and future perspectives

Shakya, Ajay; Li, Yingzi; Chang, Nai-wen; Liu, Xiaohua

doi:10.1016/j.compositesb.2024.111673

Composites Part B: Engineering

2024

DOI: 10.1016/j.compositesb.2024.111673

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Supra-alveolar bone regeneration: Progress, challenges, and future perspectives

Ajay Shakya,

Yingzi Li,

Nai-wen Chang

et al.

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Cited by 3 publications

References 132 publications

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Autologous myokine-loaded pre-vascularized bioactive scaffold enhances bone augmentation

Wang,

Qiu,

Yang

et al. 2025

Composites Part B: Engineering

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Autologous myokine-loaded pre-vascularized bioactive scaffold enhances bone augmentation

Wang,

Qiu,

Yang

et al. 2025

Composites Part B: Engineering

View full text Add to dashboard Cite

Egg white-derived nanocomposite microspheres for alveolar bone defects management

Hou,

Jin,

Sun

et al. 2025

Composites Science and Technology

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Jawbone periosteum‐derived cells with high osteogenic potential controlled by R‐spondin 3

Zhang,

Zhu,

Jin

et al. 2024

The FASEB Journal

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The jawbone periosteum, the easily accessible tissue responding to bone repair, has been overlooked in the recent development of cell therapy for jawbone defect reconstruction. Therefore, this study aimed to elucidate the in vitro and in vivo biological characteristics of jawbone periosteum‐derived cells (jb‐PDCs). For this purpose, we harvested the jb‐PDCs from 8‐week‐old C57BL/6 mice. The in vitro cultured jb‐PDCs (passages 1 and 3) contained skeletal stem/progenitor cells and exhibited clonogenicity and tri‐lineage differentiation capacity. When implanted in vivo, the jb‐PDCs (passage 3) showed evident ectopic bone formation after 4‐week subcutaneous implantation, and active contribution to repair the critical‐size jawbone defects in mice. Molecular profiling suggested that R‐spondin 3 was strongly associated with the superior in vitro and in vivo osteogenic potentials of jb‐PDCs. Overall, our study highlights the significance of comprehending the biological characteristics of the jawbone periosteum, which could pave the way for innovative cell‐based therapies for the reconstruction of jawbone defects.

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Supra-alveolar bone regeneration: Progress, challenges, and future perspectives

Cited by 3 publications

References 132 publications

Autologous myokine-loaded pre-vascularized bioactive scaffold enhances bone augmentation

Autologous myokine-loaded pre-vascularized bioactive scaffold enhances bone augmentation

Egg white-derived nanocomposite microspheres for alveolar bone defects management

Jawbone periosteum‐derived cells with high osteogenic potential controlled by R‐spondin 3

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