Supra-ependymal serotoninergic nerves in mammalian brain: Morphological, pharmacological and functional studies

Lorez, H.P.; Richards, John

doi:10.1016/0361-9230(82)90179-4

Cited by 52 publications

(21 citation statements)

References 114 publications

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“…This result is in line with our previous data showing significant decreases in cell proliferation in SVZ after acute or chronic 5-HT depletion (Brezun and Daszuta, 1999). Indeed, the profuse network of 5-HT fibers in the walls of the cerebral ventricles has long been described in the mammalian brain (Lorez and Richards, 1982) and using paracrine mode of transmission, 5-HT can reach various cell populations in the surroundings, notably the neural stem cells or progenitors. As in the hippocampus, this observation suggests that the site of 5-HT action should be local, and 5-HT1A possibly located on progenitors and/or astrocytes can participate in this regulation.…”

Section: Regulation Of Cell Proliferation and Neurogenesis In The Svzsupporting

confidence: 92%

Serotonin-Induced Increases in Adult Cell Proliferation and Neurogenesis are Mediated Through Different and Common 5-HT Receptor Subtypes in the Dentate Gyrus and the Subventricular Zone

Banasr

Héry

Printemps

et al. 2003

Neuropsychopharmacol

476

319

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Increase in serotonin (5-HT) transmission has profound antidepressant effects and has been associated with an increase in adult neurogenesis. The present study was aimed at screening the 5-HT receptor subtypes involved in the regulation of cell proliferation in the subgranular layer (SGL) of the dentate gyrus (DG) and the subventricular zone (SVZ) and to determine the long-term changes in adult neurogenesis. The 5-HT1A, 5-HT1B, and 5-HT2 receptor subtypes were chosen for their implication in depression and their location in/ or next to these regions. Using systemic administration of various agonists and antagonists, we show that the activation of 5-HT1A heteroreceptors produces similar increases in the number of bromodeoxyuridine-labeled cells in the SGL and the SVZ (about 50% over control), whereas 5-HT2A and 5-HT2C receptor subtypes are selectively involved in the regulation of cell proliferation in each of these regions. The activation of 5-HT2C receptors, largely expressed by the choroid plexus, produces a 56% increase in the SVZ, while blockade of 5-HT2A receptors produces a 63% decrease in the number of proliferating cells in the SGL. In addition to the influence of 5-HT1B autoreceptors on 5-HT terminals in the hippocampus and ventricles, 5-HT1B heteroreceptors also regulate cell proliferation in the SGL. These data indicate that multiple receptor subtypes mediate the potent, partly selective of each neurogenic zone, stimulatory action of 5-HT on adult brain cell proliferation. Furthermore, both acute and chronic administration of selective 5-HT1A and 5-HT2C receptor agonists produce consistent increases in the number of newly formed neurons in the DG and/or olfactory bulb, underscoring the beneficial effects of 5-HT on adult neurogenesis.

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Section: Regulation Of Cell Proliferation and Neurogenesis In The Svzsupporting

confidence: 92%

Serotonin-Induced Increases in Adult Cell Proliferation and Neurogenesis are Mediated Through Different and Common 5-HT Receptor Subtypes in the Dentate Gyrus and the Subventricular Zone

Banasr

Héry

Printemps

et al. 2003

Neuropsychopharmacol

476

319

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“…5D–F). Although we only found these axons in aged mice, it is not a particular characteristic of aging, since these axons have been previously described in the ventricles of rat and marmoset (Lorez and Richards, 1982; Sawamoto et al, 2011). …”

Section: Resultsmentioning

confidence: 58%

Age-related changes in astrocytic and ependymal cells of the subventricular zone

Capilla-González¹,

Cebrián-Silla

Guerrero-Cázares³

et al. 2014

Glia

105

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Neurogenesis persists in the adult subventricular zone (SVZ) of the mammalian brain. During aging, the SVZ neurogenic capacity undergoes a progressive decline, which is attributed to a decrease in the population of neural stem cells (NSCs). However, the behavior of the NSCs that remain in the aged brain is not fully understood. Here we performed a comparative ultrastructural study of the SVZ niche of 2-month-old and 24-month-old male C57BL/6 mice, focusing on the NSC population. Using thymidine-labeling, we showed that residual NSCs in the aged SVZ divide less frequently than those in young mice. We also provided evidence that ependymal cells are not newly generated during senescence, as others studies suggest. Remarkably, both astrocytes and ependymal cells accumulated a high number of intermediate filaments and dense bodies during aging, resembling reactive cells. A better understanding of the changes occurring in the neurogenic niche during aging will allow us to develop new strategies for fighting neurological disorders linked to senescence.

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“…The available immunohistochemical data on the supraependymal fibers of the ventricular system of the rat are inconsistent; some investigators reported the absence of GAD immunoreactivity (Richards et al, 1981), but others found a positive reaction with the GABA antiserum after treatment with aminooxyacetic acid, an inhibitor of GABA catabolism (Harandi et al, 1986). It has been established that supraependymal fibers of the rat are principally derived from the RN (Aghajanian and Gallager, 1975;Cupédo and de Weerd, 1980;Lorez and Richards, 1982;Larsen et al, 1996). According to our electron microscopic immunocytochemical observations, the supraependymal fibers in the pineal recess of the tree shrew are also immunoreactive for TH (Kado et al, 1999).…”

Section: Discussionmentioning

confidence: 96%

Central GABAergic innervation of the mammalian pineal gland: A light and electron microscopic immunocytochemical investigation in rodent and nonrodent species

2000

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Light and electron microscopic immunocytochemical observations were made to demonstrate central pinealopetal fibers immunoreactive for gamma-aminobutyric acid (GABA) and synapses between their terminals and pinealocytes in the pineal gland of four rodent (Wistar-King rat; mouse; Syrian hamster, Mesocricetus auratus; Hartley strain guinea pig) and one nonrodent (tree shrew, Tupaia glis) species. GABA-immunoreactive myelinated and unmyelinated fibers and endings were found in the parenchyma of the pineal gland of all the animals examined. In the rodent species, GABAergic fibers were mainly found in the intermediate and proximal portions of the pineal gland and were nearly or entirely absent in the distal portion of the gland. Abundant GABAergic fibers were evenly distributed throughout the gland of the tree shrew. In all the animals, the habenular and posterior commissures contained abundant GABA-positive fibers, and some of them were followed to the pineal gland. GABA-positive endings made synaptic contact with pinealocytes, occasionally in mice and guinea pigs, and frequently in tree shrews; no synapses were observed in Syrian hamsters and rats. In the pineal gland of all the animals, GABA-immunoreactive cell bodies were not detected, and sympathetic fibers were not immunoreactive for GABA. These data indicate that GABAergic fibers are main pinealopetal projections from the brain. In view of the difference in the distribution of these fibers, central GABAergic innervation may play a more significant role in nonrodents than in rodents. The frequent occurrence of GABAergic synapses on pinealocytes in the tree shrew suggests that GABA released at these synapses directly controls activity of pinealocytes of this animal.

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Supra-ependymal serotoninergic nerves in mammalian brain: Morphological, pharmacological and functional studies

Cited by 52 publications

References 114 publications

Serotonin-Induced Increases in Adult Cell Proliferation and Neurogenesis are Mediated Through Different and Common 5-HT Receptor Subtypes in the Dentate Gyrus and the Subventricular Zone

Serotonin-Induced Increases in Adult Cell Proliferation and Neurogenesis are Mediated Through Different and Common 5-HT Receptor Subtypes in the Dentate Gyrus and the Subventricular Zone

Age-related changes in astrocytic and ependymal cells of the subventricular zone

Central GABAergic innervation of the mammalian pineal gland: A light and electron microscopic immunocytochemical investigation in rodent and nonrodent species

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