2007
DOI: 10.1523/jneurosci.1432-07.2007
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Suprachiasmatic Modulation of Noradrenaline Release in the Ventrolateral Preoptic Nucleus

Abstract: As the major brain circadian pacemaker, the suprachiasmatic nucleus (SCN) is known to influence the timing of sleep and waking. We thus investigated here the effect of SCN stimulation on neurons of the ventrolateral preoptic nucleus (VLPO) thought to be involved in promoting sleep. Using an acute in vitro preparation of the rat anterior hypothalamus/preoptic area, we found that whereas single-pulse stimulations of the SCN evoked standard fast ionotropic IPSPs and EPSPs, train stimulations unexpectedly evoked a… Show more

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Cited by 18 publications
(8 citation statements)
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“…GABAergic projections from the DMH to the VLPO could covey inhibitory effects from the SCN [6]. A direct SCN to VLPO pathway may play a role, as electrical or chemical activation of the SCN in a horizontal hypothalamic slice evokes inhibition in VLPO neurons [37].…”
Section: Hypothalamic Mechanisms Of Global Sleep Regulationmentioning
confidence: 99%
“…GABAergic projections from the DMH to the VLPO could covey inhibitory effects from the SCN [6]. A direct SCN to VLPO pathway may play a role, as electrical or chemical activation of the SCN in a horizontal hypothalamic slice evokes inhibition in VLPO neurons [37].…”
Section: Hypothalamic Mechanisms Of Global Sleep Regulationmentioning
confidence: 99%
“…It is thought that the mechanism underlying the absence of an increase in sleep propensity and performance deterioration is related to wake‐promoting (activating) inputs at the level of either the hypothalamus or the cortex (Edgar et al. , 1993; Saint‐Mleux et al. , 2007).…”
Section: The Regulation Of Global and Local Sleep Propensitymentioning
confidence: 99%
“…For example, in neurons in the cat submandibularis that synthesize both ACh and VIP, measurable release of VIP first occurs at stimulation frequencies of about 2 Hz, while ACh release is already significant at stimulation frequencies below 0.5 Hz [68]. In addition to this general firing-ratedependent phenomenon, experiments support an SCN firing-pattern-dependent inhibitory action of SCN peptide signalling on VLPO activity: while single-pulse SCN stimulation evoked standard fast inhibitory and excitatory post-synaptic potentials in the VLPO, longer duration stimulus trains to the SCN evoked a longlasting inhibition that suppressed action potential firing [100]. The necessity of train stimulation in evoking the long-lasting inhibition suggests that the response may involve peptide release, which often depends on higher firing rates, or even burst firing [66,67].…”
Section: (B) Inter-model Comparisons and Model Implicationsmentioning
confidence: 91%