Supraclavicular Brachial Plexus Block: Comparision of Two Different Doses of Dexmedetomidine as an Adjunct to Bupivacaine: A Study

Pillai, Anil Radhakrishnan; Palanisamy, Nagalakshmi; Ranjan, RV; George, Sagiev Koshy; Ramachandran, T R; Oommen, Titu George; Chinthavalli, Sujatha; Valasareddy, Sunil Kumar

doi:10.7860/jcdr/2018/35177.12074

Cited by 1 publication

(3 citation statements)

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“…21 Whereas, Gandhi et al and some studies showed significant prolongation of duration of sensorimotor block and analgesia even with lower dose (0.5 mcg/kg) of dexmedetomidine. 8,13,22,23 In our study, we observed that dose of dexmedetomidine equal to or more than 50 mcg prolonged the duration of both sensorimotor block and analgesia. Inter group comparison showed dose dependent increase in the duration of sensorimotor block and analgesia.…”

Section: Discussionsupporting

confidence: 49%

“…These results were comparable with the findings of various studies. [21][22][23][35][36][37][38] In contrast, Sinha et al, Singh et al showed no difference in duration of sensorimotor block and analgesia between 1 mcg/kg and 2 mcg/kg dose of dexmedetomidine. 33,34 Prolongation of duration of sensorimotor block and analgesia associated with dexmedetomidine might be due to its both peripheral and central effects.…”

Section: Discussionmentioning

confidence: 99%

“…17,[21][22][23][24][25][26][27][28][29][30][31] In contrast,Gandhi et al used 30 mcg of dexmedetomidine which showed delay in onset of sensorimotor block and Marhofer et al, Pillai et al used lower dose (20 mcg) of dexmedetomidine which showed faster onset of sensorymotor block. 8,13,20,23 Similarly, Rancourt et al used 1 mcg/kg of dexmedetomidine and Das et al used 2 mcg/kg of dexmedetomidine and showed no change in onset of sensorimotor block.…”

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confidence: 99%

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Supraclavicular Brachial Plexus Block: Comparison of Varying Doses of Dexmedetomidine with Ropivacaine

Shakya

Singh

Ghimire

et al. 2021

Kathmandu Univ. Med. J.

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Background Alpha-2 adrenergic receptor agonists have been the focus of interest nowadays as an adjuvant to local anesthesia due to its excellent sedative, analgesic, antihypertensive, anesthetic sparing and hemodynamic stabilizing properties. The ideal dose of dexmedetomidine for brachial plexus block is matter of debate. Objective To find the appropriate minimal dose of dexmedetomidine with desired clinical effects and minimal side-effects, we compared different doses (25 mcg, 50 mcg, 75 mcg and 100 mcg) of dexmedetomidine as an adjuvant to ropivacaine. Method One hundred fifty patients of ASA I and II, aged (18-60) years, weighing (50-60) kilograms undergoing upper limb surgeries under brachial plexus block were enrolled in this prospective, double blind, randomized control study. Patients in all group received 19 ml of 0.5% ropivacaine in common. In addition; group RD25, RD50, RD75 and RD100 received 25 mcg, 50 mcg, 75 mcg and 100 mcg of dexmedetomidine diluted in 1 ml of normal saline (NS) respectively whereas group RD00 received only 1 ml of NS. The duration of analgesia was the primary outcome whereas block characteristics, hemodynamic parameters, oxygen saturation, sedation score and adverse effects were taken as secondary outcome. Statistical analysis was done using ANOVA test, Chi-square test and Scheffe’s multiple comparison tests. Result The demographic profile and baseline hemodynamic variables were comparable in all five groups. Increasing dose of dexmedetomidine showed significant improvement in block characteristics but associated with increase in sedation and incidence of bradycardia. Conclusion We conclude that dexmedetomidine 50 mcg would be an appropriate dose as adjuvant to local anesthesia in brachial plexus block.

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