» Rotational malalignment of the lower extremity is a potential cause of hip, knee, and ankle pain. » Physical examination must include observation of gait and an assessment of femoral rotation and the thigh-foot axis with the patient prone. » Advanced imaging helps to quantify the degree of deformity, improving the accuracy of the preoperative plan. » Surgical correction of rotational malalignment of the femur and tibia is reserved for severe, symptomatic deformity. » Future software that allows for 3-dimensional assessment of alignment and preoperative planning will further aid in the correction of the complex deformities. Natural History An appreciation of the childhood rotational development pathway helps us to better understand associated deformity in adolescents and adults. Limb rotation starts in utero and is part of normal development. At 5 months, the normal fetus has about 20°of internal tibial torsion. At birth, many infants have internal tibial rotation (2°to 4°), increased femoral anteversion (;40°), and external contractures at the hip 3,10,17. These uterine molding effects typically Disclosure: No external funds were received in support of this study. On the Disclosure of Potential Conflicts of Interest forms, which are provided with the online version of the article, one or more of the authors checked "yes" to indicate that the author had a relevant financial relationship in the biomedical arena outside the submitted work (http://links.lww.com/JBJSREV/A407).