Supramolecular amphiphiles of Beta-cyclodextrin and Oleylamine for enhancement of vancomycin delivery

Salih, Mohammed; Omolo, Calvin A.; Agrawal, Nikhil; Walvekar, Pavan; Waddad, Ayman Y.; Mocktar, Chunderika; Ramdhin, Charlotte

doi:10.1016/j.ijpharm.2019.118881

Cited by 22 publications

(8 citation statements)

References 79 publications

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“…There were no significant changes observed in particle size distribution, polydispersity index and zeta potential values for 30 days (p > 0.05). Previous studies with amphiphilic CD derivatives and various active molecules have shown that the prepared nanosystems are stable [19,37,[67][68][69]. CDs may enhance stability by reforming physicochemical and thermodynamic properties of drug because drug was partially or totally surrounded with CDs cavity [70].…”

Section: Short-term Physical Stability Of Erl-loaded Amphiphilic CD N...mentioning

confidence: 99%

Erlotinib entrapped in cholesterol-depleting cyclodextrin nanoparticles shows improved antitumoral efficacy in 3D spheroid tumors of the lung and the liver

Varan

Akkın

Demirtürk

et al. 2020

Journal of Drug Targeting

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Erlotinib (ERL), a tyrosine kinase inhibitor approved for therapeutic use in nonsmall cell lung cancer is further researched for eventual liver cancer treatment.However, conventional ERL has important bioavailability problems resulting from oral administration, poor solubility and gastrointestinal degradation into inactive metabolites. Alternative administration routes and nanoparticulate drug delivery systems are studied to prevent or reduce these drawbacks. In this study, ERL-loaded CD nanosphere and nanocapsule formulations capable of cholesterol depletion in resistant cancer cells were evaluated for ERL delivery. Drug loading and release profile depended largely on the surface charge of nanoparticles.Antiproliferative activity data obtained from 2D and 3D cell culture models demonstrated that polycationic βCD nanocapsules were the most effective formulation for ERL delivery to lung and liver cancer cells. 3D tumor uptake studies further revealed that nanocapsule formulations penetrated deeper into the tumor through the multilayered cells. Furthermore, all formulations were able to extract membrane cholesterol from lung and liver cancer cell lines, indicating induction of apoptosis and overcoming drug resistance. In conclusion, given their tumoral penetration and cell membrane cholesterol depletion abilities, amphiphilic CD nanocapsules emerge as promising alternatives to improve the safety and efficiency of ERL treatment of both liver and lung tumors.

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Section: Short-term Physical Stability Of Erl-loaded Amphiphilic CD N...mentioning

confidence: 99%

Erlotinib entrapped in cholesterol-depleting cyclodextrin nanoparticles shows improved antitumoral efficacy in 3D spheroid tumors of the lung and the liver

Varan

Akkın

Demirtürk

et al. 2020

Journal of Drug Targeting

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“…Cyclodextrin (CD) [ 64 , 65 , 66 , 67 ] inclusion complexes, CD coupling, supramolecular hydrogels, and supramolecular micelles are the most frequently used CD-based controlled release systems [ 176 ]. By hydrophobic inclusion of oleylamine in β-CD, a supramolecular amphiphile was prepared, forming a self-assembled nanovesicles showing a size of 125.1 ± 8.30 nm and zeta potential of 19.3 ± 9.20 mV exhibiting sustained release of encapsulated VAN during 48 h and showing 2- and 4-fold lower minimum inhibitory concentrations (MICs) against S. aureus and MRSA as well as 459-fold reduction of intracellular bacteria using infected human embryotic kidney cells (HEK), and an 8-fold reduction in infected macrophages compared to bare drug [ 177 ]. Inclusion complexes of artemisinin and β-CD enhanced the solubility and antibacterial activity against MRSA achieving the inhibition rate of 99.94% after 4 days due to increased membrane permeability and inhibition of respiratory metabolism of MRSA [ 178 ].…”

Section: Applied Nanomaterialsmentioning

confidence: 99%

Advances in Nanostructures for Antimicrobial Therapy

Jampílek

Kráľová

2022

Materials

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Microbial infections caused by a variety of drug-resistant microorganisms are more common, but there are fewer and fewer approved new antimicrobial chemotherapeutics for systemic administration capable of acting against these resistant infectious pathogens. Formulation innovations of existing drugs are gaining prominence, while the application of nanotechnologies is a useful alternative for improving/increasing the effect of existing antimicrobial drugs. Nanomaterials represent one of the possible strategies to address this unfortunate situation. This review aims to summarize the most current results of nanoformulations of antibiotics and antibacterial active nanomaterials. Nanoformulations of antimicrobial peptides, synergistic combinations of antimicrobial-active agents with nitric oxide donors or combinations of small organic molecules or polymers with metals, metal oxides or metalloids are discussed as well. The mechanisms of actions of selected nanoformulations, including systems with magnetic, photothermal or photodynamic effects, are briefly described.

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“…Salih et al utilized inclusion complexation to synthesis and construct an innovative sugarbased cationic amphiphile (BCD-OLA) derivative from a Betacyclodextrin (BCD) head and a long C18 carbon chain with a terminal amine; oleylamine (OLA). [40] The hydrophobic inclusion of OLA in BCD is one of the mechanisms by which amphiphiles are formed. In comparison to free vancomycin, the BCD-OLA loaded vancomycin displayed a two-fold and four-fold reduced MIC against Staphylococcus aureus (S. aureus) and Methicillinresistant Staphylococcus aureus (MRSA).…”

Section: Antibiotic Loaded Polymeric Nanoplatformsmentioning

confidence: 99%

Polymeric Nanoplatforms for the Delivery of Antibacterial Agents

Chen

Huang

Jin

2022

Macro Chemistry & Physics

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Antibiotic therapy is the first choice for the treatment of bacterial infections in the clinic. However, the continuously increasing bacterial resistance makes traditional antibiotic therapy difficult to achieve ideal therapeutic performance, necessitating the development of new antibacterial strategies. Polymeric nanoparticles have received much attention in biomedical applications. They can be used as nanocarriers to deliver a variety of antibacterial agents to the infected area. Compared to traditional drug delivery systems, polymeric nanoparticles show various advantages, including improved drug stability, long circulation time, controlled drug release, selective drug accumulation, and so on. This review summarizes the current applications of polymeric nanoparticles for the delivery of antibacterial agents. First, an extensive review of the applications of polymeric nanoplatforms in the delivery of various antibacterial drugs is conducted. The mechanisms and strategies of various stimuli-responsive polymeric nanoplatforms are then discussed, especially focusing on how to improve the antibacterial efficacy and reduce the side effects. Finally, the challenges of future developments of polymeric nanoplatforms in the delivery of antibacterial agents are discussed.

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Supramolecular amphiphiles of Beta-cyclodextrin and Oleylamine for enhancement of vancomycin delivery

Cited by 22 publications

References 79 publications

Erlotinib entrapped in cholesterol-depleting cyclodextrin nanoparticles shows improved antitumoral efficacy in 3D spheroid tumors of the lung and the liver

Erlotinib entrapped in cholesterol-depleting cyclodextrin nanoparticles shows improved antitumoral efficacy in 3D spheroid tumors of the lung and the liver

Advances in Nanostructures for Antimicrobial Therapy

Polymeric Nanoplatforms for the Delivery of Antibacterial Agents

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