Supramolecular Analytical Application of Cucurbit[n]urils Using Fluorescence Spectroscopy

Probing the pharmacokinetics of cucurbit[7, 8 and 10]uril: and a dinuclear ruthenium antimicrobial complex encapsulated in cucurbit[10]uril

“…1) has recently attracted considerable attention through the realisation of a wide-range of potential applicationsincluding catalysis, the modification of electro-chemical properties, the enhancement of some analytical processes, the synthesis of nano-materials and supramolecular polymers, for drug delivery and the modification of various biological processes. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] The Q[n] are available in a range of cavity sizes prescribed by the number of glycoluril moieties for a particular member (n = 5-8 and 10). [1][2][3] Other non-classical Q[n] members are also now available, including Q [13][14][15], which have limited cavities as a consequence of their twisted structures, in the form of Möbius strips.…”

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] The Q[n] are available in a range of cavity sizes prescribed by the number of glycoluril moieties for a particular member (n = 5-8 and 10). [1][2][3] Other non-classical Q[n] members are also now available, including Q [13][14][15], which have limited cavities as a consequence of their twisted structures, in the form of Möbius strips. 17,18 The three Q[n] members that are of prime interest in the area of drug delivery are Q [7, 8 and 10], which have cavities large enough to accommodate drug molecules or parts of a drug molecule with cross-sections within the portal size ranges of 5.4-10.6 Å.…”

Reversible Shape‐Morphing and Fluorescence‐Switching in Supramolecular Nanomaterials Consisting of Amphiphilic Cyanostilbene and Cucurbit[7]uril

“…Briefly, we applied this shape‐morphing nanomaterial consisting of cyanostilbene 3 and CB[7] to a fluorescence “turn‐on” biological sensor through a dynamic competitive guest exchange reaction. Because biological fluorescence sensors based on the dynamic competitive guest exchange reaction using CB[7] in aqueous solution are commonly “turn‐off” sensors exploiting the fluorescence quenching phenomenon, materializing fluorescence “turn‐on” biological sensor in this work is to be noted as a significant progress as well.…”

“…Therefore, on the basis of the complementary characteristics of 1 exhibitinge xcellent hydrophobic self-assembling propensity and 2 showing high hydrophilicity,w ed esigned in this work an ew cyanostilbene-based amphiphilic molecule, which is (Z)-4-(4-(2-(3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1-cyanovinyl)phenyl)-1-methylpyridin-1-iumc hloride (nameda sc yanostilbene 3,S cheme 1a)f or aw ell-structured amphiphilic nanomaterial with bright luminescencei np ure water.I na ddition, to endow cyanostilbene 3 with shape-morphing and fluorescence-switching abilities throughh ost-guesti nteraction (Scheme 1b), [26][27][28][29][30][31] we decided to employ cucurbit [7]uril(CB [7],Scheme 1a)asapartner molecule of cyanostilbene 3.D ue to significant water-solubility and non-toxicity of the CB [7] compared to other macrocyclic hosts, [31][32][33][34] we expected using CB [7] as the partner molecule of cyanostilbene 3 is the best way to achieve the biosensing nanomaterials in pure water.B riefly,w ea ppliedt his shapemorphing nanomaterial consisting of cyanostilbene 3 and CB [7] to af luorescence" turn-on" biological sensort hrough a dynamic competitive guest exchange reaction. Because biological fluorescence sensors based on the dynamic competitive guest exchanger eactionu sing CB [7] in aqueouss olution are commonly "turn-off" sensors exploiting the fluorescence quenching phenomenon, [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] materializing fluorescence" turnon" biological sensorinthis work is to be noted as asignificant progress as well.…”

Brilliant Green Decorated Graphene Oxide for the Detection of Cucurbit[7]uril

“…However, the binding properties of cucurbituris are very unique and for that purpose they have gained much attention recent days [2]. Based on the structural features of cucurbiturils, they have been explored as portals of the cucurbiturils are built by the rim of carbonyls, while the hydrophobic cavities of cucurbiturils are having the potential to interact with the hydrophobic molecules [3], [4]. The basic building blocks of the cucurbiturils are made up of glycolurils and formaldehyde by the acid-catalyzed condensation, which provided the hydrophobic interior and hydrophilic exterior to attract the molecules of choice (guests) [5], [6].…”