Supramolecular antibiotics: a strategy for conversion of broad-spectrum to narrow-spectrum antibiotics for<i>Staphylococcus aureus</i>

Koyasseril-Yehiya, Thameez M.; García‐Heredia, Alam; Anson, Francesca; Rangadurai, Poornima; Siegrist, M. Sloan; Thayumanavan, S.

doi:10.1039/d0nr04886k

Cited by 5 publications

(5 citation statements)

References 39 publications

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“…We have specifically shown that the H-bonding interaction among the attached functional groups influences the internal order of the self-assembled nanostructures and consequently the thermodynamic landscape of biomolecular adsorption. Further studies involving variation in the π-system and/or nature of the H-bonding group are underway with the broad objective to explore π-amphiphiles as supramolecular biomaterials. − …”

Section: Discussionmentioning

confidence: 99%

Thermodynamic Insights into Protein Adsorption on Supramolecular Assemblies of π-Amphiphiles

Rajdev

Ghosh

2021

J. Phys. Chem. B

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Nonspecific adsorption of proteins on the surface of nanocarriers plays a critical role in their cellular uptake and other biological functions. This article reports vesicular assemblies of two πamphiphiles (NDI-1 and NDI-2) and thermodynamic aspects of their interaction with bovine serum albumin (BSA). Both contain a hydrophobic naphthalene-diimide (NDI) core and two oligo-oxyethylene (OE) wedges but differ by the presence of the hydrazide group in NDI-1. NDI-2 exhibits a constricted π-stacking and enthalpy-driven adsorption of BSA. In contrast, NDI-1 exhibits a stronger interaction due to enhanced entropy contribution. It is postulated that a tight packing of NDI chromophores in NDI-2 results in an inadequate space in the corona, leading to the dehydration of OE chains, which contributes to the observed enthalpy-driven binding. On the other hand, due to H-bonding along the direction of π-stacking in NDI-1, an enhanced interchromophoric distance provides more space in the shell, resulting in less dehydration of the OE chains, which results in an entropy gain from the BSA binding-induced release of water from the OE chains. Intercalation of an electron-rich pyrene in the electron-deficient NDI-1 stack further reduces the grafting density of the OE chains, resulting in negligible BSA adsorption, similar to a stealth polymer. A correlation can be seen between the thermodynamic landscape of the protein adsorption and the trend of their lower critical solution temperature (LCST), which follows the order NDI-1 + Py < NDI-1 < NDI-2.

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Section: Discussionmentioning

confidence: 99%

Thermodynamic Insights into Protein Adsorption on Supramolecular Assemblies of π-Amphiphiles

Rajdev

Ghosh

2021

J. Phys. Chem. B

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“…80 The ANAs underwent a stable/collapsed transition when exposed to SplB, and Ag + released from the collapsed ANAs exhibited biocidal activity to MRSA. Other enzymes such as glutamyl endonuclease (V8 enzyme), 81 type IV collagenases, 82 and β-lactamases 83 have also been reported as triggers for antibiotic release. In summary, these enzyme-responsive platforms achieved on-demand antibiotics release and demonstrated good antibacterial efficacy at the infection site.…”

Section: Biomaterials Sciencementioning

confidence: 99%

Recent advances in responsive antibacterial materials: design and application scenarios

Zhang

Duan

2023

Biomater. Sci.

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“…139 In aqueous solutions, these dendrimers containing penta(ethylene glycol) units as the hydrophilic moiety and decyl chain as hydrophobic moiety were found to form micelle-like aggregates within nanometer range. 140,141 Temperature-sensitivity due to the presence of ethylene glycol units were evaluated in different dendrimer generations. 142 A generation-dependent temperature-sensitivity was observed, due to the aggregation size and cooperativity when PEG moieties were tethered together in self-assembled dendrons (Fig.…”

Section: Impact Of Molecular Structures On ''Facially Amphiphilic'' D...mentioning

confidence: 99%

Molecular bases for temperature sensitivity in supramolecular assemblies and their applications as thermoresponsive soft materials

et al. 2022

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Supramolecular antibiotics: a strategy for conversion of broad-spectrum to narrow-spectrum antibiotics forStaphylococcus aureus

Abstract: The propensity of broad-spectrum antibiotics to indiscriminately kill both pathogenic and beneficial bacteria has a profound impact on the spread of resistance across multiple bacterial species. Alternative approaches that narrow...

Cited by 5 publications

References 39 publications

Thermodynamic Insights into Protein Adsorption on Supramolecular Assemblies of π-Amphiphiles

Thermodynamic Insights into Protein Adsorption on Supramolecular Assemblies of π-Amphiphiles

Recent advances in responsive antibacterial materials: design and application scenarios

Molecular bases for temperature sensitivity in supramolecular assemblies and their applications as thermoresponsive soft materials

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