Supramolecular Approach in Photodynamic and Photothermal Therapies

Kejík, Zdeněk; Kaplánek, Robert; Břı́za, Tomáš; Havlík, Martin; Králová, Jarmila; Martásek, Pavel; Král, Vladimír

doi:10.1016/b978-0-12-409547-2.12562-4

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“…Cholesterol concentration in human blood is clinically important in providing information for disease control and prevention [6]. Several studies have been conducted on the pathological states caused by imbalance of cholesterol [7][8][9][10]. Hence, the development of new…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectral characterization, molecular modeling, antibacterial and antioxidant activities and stability study of binuclear Pd(II) and Ru(III) complexes with novel bis-[1-(2-[(2-hydroxynaphthalen-1-yl)methylidene]amino}ethyl)-1-ethyl-3-phenylthiourea] ligand: Application to detection of cholesterol

Terbouche

Ait‐Ramdane‐Terbouche

Bendjilali

et al. 2018

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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A novel bis-[1-(2-[(2-hydroxynaphthalen-1-yl) methylidene]amino}ethyl)-1-ethyl-3-phenylthiourea] Schiff base (L) and its binuclear palladium and ruthenium complexes have been prepared and characterized by ESI-MS, elemental analysis, NMR (H NMR, C NMR, COSY, NEOSY and HSQC), FT-IR, ATR, UV-Visible spectra, TGA measurements, conductivity and cyclic voltammetry. The experimental results and the molecular parameters calculated using DFT method revealed a square planar geometry around Pd and octahedral geometry around ruthenium metal. The antibacterial activity of the ligand L and its complexes was evaluated against different human bacteria. In addition, the formation constants of the synthesized Schiff base-metal complexes and the systems formed with these chelates and cholesterol were estimated using spectrophotometric technique. The detection of cholesterol using novel Pd and Ru Schiff base complexes was studied using fluorometric method, and the measurements showed that the sensitive fluorometric response towards cholesterol analysis was determined using palladium complex. The limit of detection (LOD) of cholesterol calculated using this complex (4.6 μM) is lower (better) than LOD found using ruthenium complex (19.1 μM) and different compounds previously published around linear range of 0-5 mM.

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