Supramolecular Behaviour and Fluorescence of Rhodamine-Functionalised ROMP Polymer

Abstract

<p>Inherently fluorescent polymers are of interest in materials and medicine. We report a ring-opening metathesis polymerisation (ROMP) platform for creation of amphiphilic block copolymers in which one block is formed from rhodamine B-containing monomers. The polymers self-assemble into well-defined micelles which are able to sequester molecular dyes and further interact with them by energy transfer. Despite incorporating a cationic dye known to bind DNA, the polymer micelles do not interact with DNA, indicating that they are potentially safe for use in bioanalytical applications.</p>

Essential Oils and Eutectic Solvents in the Povarov Reaction for the Synthesis of Tetrahydroquinolines: A Lesson of Cycloadditions, Stereochemistry, and Green Chemistry

“…Regarding the mechanism, although there is debate in literature, it is believed that the reaction starts with the formation of Narylimines (azadiene) in the more stable E stereoisomer which are activated by the catalyst and might follow a formal [4 + 2] concerted cycloaddition through a trans-endo-favored transition state followed by a 1,3-hydrogen shift or a stepwise polar mechanism proceeding via zwitterionic intermediates (Figure 3). 31−34 Over the last two decades, this journal has published several Diels−Alder laboratory experiments to construct several carboand heterocycles were different topics of this reaction such as the effects of kinetic vs thermodynamic control on endo/exo adducts, 35,36 regioselectivity, 37 diastereoselectivity, 38,39 heat source, 40−42 and solvent free conditions, 43 have been addressed. These experiments have contributed to understanding and gaining experience with classic reactions in undergraduate organic chemistry courses; however, with the increasing interest in green chemistry, other topics like metrics and use of alternative solvents and renewable building blocks should be also considered.…”