Supramolecular Complexation of Biologically Important Thioflavin‐T with p‐Sulfonatocalix[4]arene

Abstract

The inclusion of thioflavin T (ThT) with p‐sulfonatocalix[4]arene (p‐SC4) is briefly discussed in solution as well as solid state. The restricted rotation of C−C single bond between indole and benzene ring system is the reason for emission property of ThT. The encapsulation of ThT using a flexible charged host molecule exploit the correlation between the C−C single bond rotation and emission enhancement. The binding of ThT with p‐SC4 in solution state is studied using absorption, emission, electrochemical, 1H NMR and rotating frame nuclear overhauser effect spectroscopy (ROESY) techniques. A stable water insoluble supramolecular complex is synthesized from water soluble ThT and p‐SC4. The structural features of the prepared solid complex is established from infrared (FT‐IR), powder X‐ray diffraction (XRD), Mass, 1H NMR and nuclear overhauser effect spectroscopy (NOESY) analyses.

Host–Guest Encapsulation of RIBO with TSC4X: Synthesis, Characterization, and Its Application by Physicochemical and Computational Investigations

“…PXRD spectral analysis offers substantial evidence in favor of the formation of RIBO-TSC4X encapsulated complex derived from pure RIBO and TSC4X . The individual characteristic diffraction pattern of RIBO and TSC4X was found to be altered after complexation.…”

“…PXRD spectral analysis offers substantial evidence in favor of the formation of RIBO-TSC4X encapsulated complex derived from pure RIBO and TSC4X. 54 The individual characteristic diffraction pattern of RIBO and TSC4X was found to be altered after complexation. The construction of a new solid encapsulated complex of RIBO-TSC4X can be confirmed by comparing the diffraction outlines of the pure compounds with their corresponding complex.…”