Supramolecular core–glycoshell polythiophene nanodots for targeted imaging and photodynamic therapy

Han, Hai; Wang, Chang Zheng; Zang, Yi; Li, Jia; James, Tony D.; He, Xiao‐Peng

doi:10.1039/c7cc04525e

Cited by 21 publications

(19 citation statements)

References 45 publications

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“…d) Structure of P3HT and two glycosylated probes before the self‐assembly with PSMA to form a complex FACILITATING cell entry and cell death, and fluorescence imaging in two cells with receptors of galactose and mannose, respectively, as well as in control HeLa cells. Reproduced with permission . Copyright 2017, The Royal Society of Chemistry.…”

Section: Carbohydrate‐conjugated Nanomaterialsmentioning

confidence: 99%

“…Poly(3‐hexylthiophene‐2,5‐diyl) (P3HT) nanodots assembled with poly(styrene‐ co ‐maleic anhydride) (PSMA) and galactose‐/mannose‐conjugated dicyanomethylene‐4H‐pyran (DCM) was complexed with poly(9,9‐dioctylfluorenyl‐2,7‐diyl) (PFO) before the self‐assembly with galactose‐/mannose‐conjugated DCM fluorophores, with FRET suppressing the fluorescence of PFO while enhancing that of glyco‐DCM, for targeted PNA/Con A detection and cancer cell imaging/PDT in Hep‐G2/MDA‐MB‐231 cells with improved water solubility (Figure 17d). DCM fluorescence was decreased with the increase of PFO fluorescence upon lectins or cell receptors, thus enabling their detection . Self‐assembly of PDI (perylenediimide)‐based galactosyl clusters loaded DCM were used to visualize Hep‐G2 cells .…”

Section: Carbohydrate‐conjugated Nanomaterialsmentioning

confidence: 99%

“…CuAAC (copper‐catalyzed azide–alkyne cycloaddition) was one of the most commonly used strategy shown in this review, due its high chemical yield, wide substrate scope, and mild reaction conditions . Researchers have also extensively exploited the high affinity of sulfur functional groups for Au .…”

Section: Brief Overview Of the Bio‐conjugation Chemistry And Strategimentioning

confidence: 99%

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Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

Kwon

Yan

et al. 2020

Adv Funct Materials

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Human beings are “machines” that use endogenously produced biomolecules as “components” in signaling and for the maintenance of the body. These biomolecules consist of proteins, nucleic acids, and carbohydrates, which can either be extracted from biological substrates or synthesized by chemical/biochemical methods. These biomolecules have the ability to recognize/interact with other biomolecules that are overexpressed in disease cells. For targeted theranostics, strategies to chemically incorporate these natural biomolecules with advanced materials to treat human diseases by imaging‐guided drug delivery or photodynamic/photothermal therapy are proposed, with improved biocompatibility. Herein, recent research on construction of quantum dots, nanoparticles, and 2D material platforms decorated with antibodies, peptides, nucleic acid aptamers, carbohydrates, and folic acid for targeted diagnosis and treatment are summarized and discussed. In addition, the various strategies required to construct effective functional materials for targeted cancer therapy are highlighted. The hope is that this review can inspire and guide those that are interested in the field of biomedicine to rationally design and develop new target‐based theranostic materials.

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Section: Carbohydrate‐conjugated Nanomaterialsmentioning

confidence: 99%

Section: Carbohydrate‐conjugated Nanomaterialsmentioning

confidence: 99%

Section: Brief Overview Of the Bio‐conjugation Chemistry And Strategimentioning

confidence: 99%

See 1 more Smart Citation

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

Kwon

Yan

et al. 2020

Adv Funct Materials

Self Cite

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“…Han et al. developed (3‐hexylthiophene‐2,5‐diyl) (P3HT) nanodots with multivalent glycoshell by means of simple construction to demonstrate their enhanced PDT efficacy towards triple‐negative breast cancer cells . Several release strategies have been also introduced to effectively release PS on the on‐target sites.…”

Section: Mannose‐based Nanomaterials In Biomedical Applicationsmentioning

confidence: 99%

“…Han et al developed (3-hexylthiophene-2,5-diyl) (P3HT) nanodots with multivalentg lycoshell by meanso fs imple construction to demonstrate their enhanced PDT efficacyt owards triple-negative breastc ancer cells. [55] Severalr elease strategies have been also introduced to effectively releaseP So nt he on-target sites. Staegemann et al combined both reductively cleavable disulfide linkersa nd acid-cleavable acetal linkers into the mannosylated hPG-multiple PS system, whichw as advantageous for the targeted delivery of PS towards tumor cells as well as bacteria.…”

Section: Mannose-based Nanomaterials For Photodynamic Therapy(pdt)mentioning

confidence: 99%

Mannose‐Functionalized Nanoscaffolds for Targeted Delivery in Biomedical Applications

Wei

Seeberger

et al. 2018

Chemistry An Asian Journal

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Targeted drug delivery by nanomaterials has been extensively investigated as an effective strategy to surmount obstacles in the conventional treatment of cancer and infectious diseases, such as systemic toxicity, low drug efficacy, and drug resistance. Mannose‐binding C‐type lectins, which primarily include mannose receptor (MR, CD206) and dendritic cell‐specific intercellular adhesion molecule‐3‐grabbing non‐integrin (DC‐SIGN), are highly expressed on various cancer cells, endothelial cells, macrophages, and dendritic cells (DCs), which make them attractive targets for therapeutic effect. Mannosylated nanomaterials hold great potential in cancer and infection treatment on account of their direct therapeutic effect on targeted cells, modulation of the tumor microenvironment, and stimulation of immune response through antigen presentation. This review presents the recent advances in mannose‐based targeted delivery nanoplatforms incorporated with different therapies in the biomedical field.

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Photosensitizers for Photodynamic Therapy

Lan

Zhao

Liu

et al. 2019

Adv Healthcare Materials

790

479

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As an emerging clinical modality for cancer treatment, photodynamic therapy (PDT) takes advantage of the cytotoxic activity of reactive oxygen species (ROS) that are generated by light irradiating photosensitizers (PSs) in the presence of oxygen (O2). However, further advancements including tumor selectivity and ROS generation efficiency are still required. Substantial efforts are devoted to design and synthesize smart PSs with optimized properties for achieving a desirable therapeutic efficacy. This review summarizes the recent progress in developing intelligent PSs for efficient PDT, ranging from single molecules to delicate nanomaterials. The strategies to improve ROS generation through optimizing photoinduced electron transfer and energy transfer processes of PSs are highlighted. Moreover, the approaches that combine PDT with other therapeutics (e.g., chemotherapy, photothermal therapy, and radiotherapy) and the targeted delivery in cancer cells or tumor tissue are introduced. The main challenges for the clinical application of PSs are also discussed.

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Supramolecular core–glycoshell polythiophene nanodots for targeted imaging and photodynamic therapy

Cited by 21 publications

References 45 publications

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

Mannose‐Functionalized Nanoscaffolds for Targeted Delivery in Biomedical Applications

Photosensitizers for Photodynamic Therapy

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