Supramolecular Cu(<scp>ii</scp>) nanoparticles supported on a functionalized chitosan containing urea and thiourea bridges as a recoverable nanocatalyst for efficient synthesis of 1<i>H</i>-tetrazoles

Bondarian, Shirin; Dekamin, Mohammad G.; Valiey, Ehsan; Naimi-Jamal, M. Reza

doi:10.1039/d3ra01989f

Cited by 4 publications

(1 citation statement)

References 137 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The invention of MCRs goes back to middle of 19th century by pioneer scientists including Strecker 28,43 , Hantzsch 44,45 , Biginelli 39,46 . MCRs are convergent reactions, in which more than two commercially accessible precursors have been mixed together to react and form important acyclic or heterocyclic products with high bond formation index (BFI) [47][48][49][50][51][52][53] . In recent decades, MCRs have emerged as an interesting tool that allows the simple synthesis of complex molecules in one-pot synthesis, without separating and purifying intermediates; therefore, it leads to cost, time and energy reduction [54][55][56][57][58] .…”

Section: Introductionmentioning

confidence: 99%

Magnetic DL-methionine grafted to chitosan by EDTA linker nanomaterial: a highly efficient multifunctional organocatalyst for the synthesis of highly substituted imidazole derivatives under green conditions

Dohendou,

Dekamin,

Dehnamaki

et al. 2024

Preprint

View full text Add to dashboard Cite

In this research, a novel protocol for the synthesis of imidazole derivatives with various substitutions has been investigated in the presence of a new and highly effective magnetic decorated DL-methionine amino acid grafted onto the chitosan backbone by using EDTA linker (CS − EDTA − MET@Fe3O4) under green chemistry conditions. The CS − EDTA − MET@Fe3O4 nanocomposite was properly characterized by using FTIR, EDX, XRD, FESEM, TGA and VSM spectroscopic, microscopic, or analytical methods. The CS − EDTA − MET@Fe3O4 nanocomposite was used as a highly efficient heterogeneous organocatalyst for the synthesis of a wide range of three- and four-substituted imidazole derivatives, as an important pharmaceutical scaffold, through multicomponent reactioins (MCRs) strategy. The CS − EDTA − MET@Fe3O4 multifunctional nanocatalyst exhibited high catalytic activity, selectivity, and stability to promote the reactions of benzoin or benzyl, different aldehyde derivatives, and ammonim acetate as well as aromatic or aliphatic amine derivatives in EtOH as green solvent. Key advantages of the present protocol are high to excellent yields, the use of a low loading renewable, bio-based and biodegredable chitosan- as well as amino acid-based nanomaterial, and simple procedure for the preparation of CS − EDTA − MET@Fe3O4 nanomaterial and synthesis of a wide range of imoidazole derivatives. In addition, the catalyst's properties, including its magnetic properties and appropriate surface area characteristicscontribute to its excellent catalytic performance. Fuerthermore, the CS − EDTA − MET@Fe3O4 nanocatalyst can be used for up to six cycles for the preparation of imidazole derivatives with only a slight decrease in its catalytic activity.

show abstract

Section: Introductionmentioning

confidence: 99%

Magnetic DL-methionine grafted to chitosan by EDTA linker nanomaterial: a highly efficient multifunctional organocatalyst for the synthesis of highly substituted imidazole derivatives under green conditions

Dohendou,

Dekamin,

Dehnamaki

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Polyhexamethylene biguanidine coated silver nanoparticles embedded into chitosan thiourea/PVA nanofibers as wound healing mats: In vitro and in vivo studies

Nematollahi,

Maghsoudian,

Motasadizadeh

et al. 2025

Carbohydrate Polymers

View full text Add to dashboard Cite

Fabrication of MXene-based membranes and their application in per- and polyfluorinated substances removal: Comparison with commercial membranes, challenges, and future improvements

Ghanbari,

Wu,

Heynderickx

2025

Coordination Chemistry Reviews

View full text Add to dashboard Cite

Supramolecular Cu(ii) nanoparticles supported on a functionalized chitosan containing urea and thiourea bridges as a recoverable nanocatalyst for efficient synthesis of 1H-tetrazoles

Abstract: Newly synthesized supported Cu(ii) nanoparticles were designed. The obtained supramolecular nanocomposite promotes multicomponent cascade Knoevenagel condensation/click 1,3-dipolar cycloaddition for synthesis of (E)-2-(1H-tetrazole-5-yl)-3-arylacrylenenitrile derivatives.

Cited by 4 publications

References 137 publications

Magnetic DL-methionine grafted to chitosan by EDTA linker nanomaterial: a highly efficient multifunctional organocatalyst for the synthesis of highly substituted imidazole derivatives under green conditions

Magnetic DL-methionine grafted to chitosan by EDTA linker nanomaterial: a highly efficient multifunctional organocatalyst for the synthesis of highly substituted imidazole derivatives under green conditions

Polyhexamethylene biguanidine coated silver nanoparticles embedded into chitosan thiourea/PVA nanofibers as wound healing mats: In vitro and in vivo studies

Fabrication of MXene-based membranes and their application in per- and polyfluorinated substances removal: Comparison with commercial membranes, challenges, and future improvements

Contact Info

Product

Resources

About