Supramolecular encapsulation of doxorubicin with β-cyclodextrin dendrimer: in vitro evaluation of controlled release and cytotoxicity

Toomari, Yousef; Namazi, Hassan

doi:10.1007/s10847-016-0682-4

Cited by 30 publications

(13 citation statements)

References 36 publications

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“…Thus, slightly more DOX was loaded onto SiO 2 @Ag@cysteinyl- β -CD NPs than onto SiO 2 @Ag@EDA- β -CD NPs. According to Hassan et al, β -CD is a basket-shaped oligosaccharide with a thinner and broader ring’s edge [14]. The exterior part of β -CD is hydrophilic, and its internal cavity is relatively non-polar.…”

Section: Resultsmentioning

confidence: 99%

“…A variety of studies in the food, pharmaceutical, medical, and cosmetic industries have evaluated the complexation ability of β -CD [8,9,10]. In the medical field, the inclusion complex between β -CD and doxorubicin (DOX) was first reported in the 1990s [11], and subsequent studies have examined its complex-forming ability [12,13,14]. Surface modification is essential for the introduction of β -CD as a stable ligand onto NPs (unpublished).…”

Section: Introductionmentioning

confidence: 99%

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Functionalized β-Cyclodextrin Immobilized on Ag-Embedded Silica Nanoparticles as a Drug Carrier

Kang

Baek

Hahm

et al. 2019

IJMS

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Cyclodextrins (CDs) have beneficial characteristics for drug delivery, including hydrophobic interior surfaces. Nanocarriers with β-CD ligands have been prepared with simple surface modifications as drug delivery vehicles. In this study, we synthesized β-CD derivatives on an Ag-embedded silica nanoparticle (NP) (SiO2@Ag NP) structure to load and release doxorubicin (DOX). Cysteinyl-β-CD and ethylenediamine-β-CD (EDA-β-CD) were immobilized on the surface of SiO2@Ag NPs, as confirmed by transmission electron microscopy (TEM), ultraviolet-visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FTIR) spectroscopy. DOX was introduced into the β-CD on the SiO2@Ag NPs and then successfully released. Neither cysteinyl-β-CD and EDA-β-CD showed cytotoxicity, while DOX-loaded cysteinyl-β-CD and EDA-β-CD showed a significant decrease in cell viability in cancer cells. The SiO2@Ag NPs with β-CD provide a strategy for designing a nanocarrier that can deliver a drug with controlled release from modified chemical types.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functionalized β-Cyclodextrin Immobilized on Ag-Embedded Silica Nanoparticles as a Drug Carrier

Kang

Baek

Hahm

et al. 2019

IJMS

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“…Beta-cyclodextrin (βCD) is a cyclic oligomer of glucose with a cage-like structure, and lipophilic inner cavities and hydrophilic outer surfaces [13]. βCD has fascinated researchers in the field of drug delivery systems design, due to a collection of properties including: biocompatibility, biodegradability, capability of inclusion-complex formation, large and nonpolar cavity space that traps drugs, and improved drug water solubility [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Co-Delivery of Doxorubicin and Conferone by Novel pH-Responsive β-Cyclodextrin Grafted Micelles Triggers Apoptosis of Metastatic Human Breast Cancer Cells

Rahmani

Rahimi

Iranshahi

et al. 2021

Preprint

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Adjuvant-aided combination chemotherapy is one of the most effective ways of cancer treatment by overcoming the multidrug resistance (MDR) and reducing the side-effects of anticancer drugs. In this study Conferone (Conf) was used as adjuvant in combination with Doxorubicin (Dox) for induction of apoptosis to MDA-MB-231 cells. Herein, the novel biodegradable amphiphilic β-cyclodextrin grafted poly maleate-co-PLGA was synthesized by thiol-ene addition and ring-opening process. Micelles obtained from novel copolymer showed exceptional properties such as small size of around 34.5 nm, CMC of 0.1 μg/mL, and cell internalization of around 100 % at 30 min. These novel engineered micelles were used for combination delivery of doxorubicin-conferone with high encapsulation efficiency of near 100 % for both drugs. Our results show that combination delivery of Dox and Conf to MDA-MB-231 cells had synergistic effects (CI<1). According to cell cycle and Annexin-V apoptosis analysis, Dox-Conf loaded micelle significantly induce tumor cell apoptosis (more than 98 % of cells population showed apoptosis at IC50 = 0.259 μg/mL). RT-PCR and western-blot tests show that Dox-Conf loaded βCD-g-PMA-co-PLGA micelle induced apoptosis via intrinsic pathway. Therefore, the unique design of multi-functional pH-sensitive micelles open a new perspective for the development of nanomedicines for combination chemo-adjuvant therapy against malignant cancer.

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“…27,28 Biodegradable hyperbranched polymers based on aliphatic polyester, poly(D,L-lactide) and polyaniline and five-arm and functionalized star-like polyaniline and polycaprolactone polymers with a D-glucose core have also been utilized as effective biomaterials. 29,30 Among these, dendritic nanocarriers are most favourable nanostructures because of the branching features [31][32][33][34] which are useful in multi-drug delivery systems. 35 Due to the easy deformation of linear polymers through the pores of the renal filtration membrane, their elimination via renal excretion is done easily.…”

Section: Introductionmentioning

confidence: 99%

Co‐delivery of methotrexate and doxorubicin via nanocarriers of star‐like poly(DMAEMA‐block‐HEMA‐block‐AAc) terpolymers

Saraei

Sarvari

Massoumi

et al. 2019

Polymer International

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Combined therapy is a promising strategy for clinical cancer treatment with synergistic effects. The purpose of the work reported was to evaluate a smart nanocarrier for co‐delivery of doxorubicin (DOX) and methotrexate (MTX). Since star‐like nanocarriers can load a high dose of drugs with various properties, we developed star polymer nanomicelles based on poly[(2,2‐dimethylaminoethyl methacrylate)‐block‐(2‐hydroxyethyl methacrylate)‐block‐(acrylic acid)] having potential for multi‐drug delivery. The nanomicelles demonstrated high encapsulation efficiency, i.e. 97.1% for DOX and 79.5% for MTX. To this end, the star‐like terpolymers were synthesized via atom transfer radical polymerization with pentaerythritol as an initiator. The micellar properties and dual stimuli‐responsive behaviour of the terpolymers were investigated using transmission electron microscopy, field emission scanning electron microscopy and dynamic light scattering measurements, concluding that this co‐therapy offers a promising approach for cancer treatment. © 2019 Society of Chemical Industry

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Supramolecular encapsulation of doxorubicin with β-cyclodextrin dendrimer: in vitro evaluation of controlled release and cytotoxicity

Cited by 30 publications

References 36 publications

Functionalized β-Cyclodextrin Immobilized on Ag-Embedded Silica Nanoparticles as a Drug Carrier

Functionalized β-Cyclodextrin Immobilized on Ag-Embedded Silica Nanoparticles as a Drug Carrier

Co-Delivery of Doxorubicin and Conferone by Novel pH-Responsive β-Cyclodextrin Grafted Micelles Triggers Apoptosis of Metastatic Human Breast Cancer Cells

Co‐delivery of methotrexate and doxorubicin via nanocarriers of star‐like poly(DMAEMA‐block‐HEMA‐block‐AAc) terpolymers

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