Supramolecular hydrogels based on antimycobacterial amphiphiles

Bernet, Andreas; Behr, Marina; Schmidt, Hans‐Werner

doi:10.1039/c2sm07456g

Cited by 13 publications

(12 citation statements)

References 26 publications

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“…Ag NPs were synthesized in situ and the amphiphile–Ag NPs soft nanocomposite exhibited notable antibacterial property . In addition to the hydrogels developed against normal G+ and G− bacteria, an anti‐mycobacterial supramolecular hydrogel based on amphiphiles was developed by Bernet et al It retains specific and chain‐length dependent antibacterial and anti‐mycobacterial activity while showing no antiproliferative and negligible cytotoxic effects …”

Section: Hydrogels With Inherent Antibacterial Activitymentioning

confidence: 99%

Antibacterial Hydrogels

et al. 2018

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Antibacterial materials are recognized as important biomaterials due to their effective inhibition of bacterial infections. Hydrogels are 3D polymer networks crosslinked by either physical interactions or covalent bonds. Currently, hydrogels with an antibacterial function are a main focus in biomedical research. Many advanced antibacterial hydrogels are developed, each possessing unique qualities, namely high water swellability, high oxygen permeability, improved biocompatibility, ease of loading and releasing drugs, and structural diversity. Here, an overview of the structures, performances, mechanisms of action, loading and release behaviors, and applications of various antibacterial hydrogel formulations is provided. Furthermore, the prospects in biomedical research and clinical applications are predicted.

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Section: Hydrogels With Inherent Antibacterial Activitymentioning

confidence: 99%

Antibacterial Hydrogels

et al. 2018

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“…The amphiphile−Ag NP soft nanocomposite exhibited notable antimicrobial property. Apart from disinfection of normal Gram-positive and Gramnegative bacteria, an antimycobacterial supramolecular hydrogel based on amphiphiles was developed by Bernet et al, 270 which retains specific, chain length-dependent antimicrobial and antimycobacterial activity, while showing practically negligible antiproliferative cytotoxic effects. With good antibacterial properties and negligible cytotoxicity, the clinical application of amphoteric ion hydrogel still needs to be developed.…”

Section: Amphoteric Ion Hydrogelsmentioning

confidence: 99%

Antimicrobial hydrogels: promising materials for medical application

Yang

Han

Chen

et al. 2018

IJN

321

230

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The rapid emergence of antibiotic resistance in pathogenic microbes is becoming an imminent global public health problem. Local application of antibiotics might be a solution. In local application, materials need to act as the drug delivery system. The drug delivery system should be biodegradable and prolonged antibacterial effect should be provided to satisfy clinical demand. Hydrogel is a promising material for local antibacterial application. Hydrogel refers to a kind of biomaterial synthesized by a water-soluble natural polymer or a synthesized polymer, which turns into gel according to the change in different signals such as temperature, ionic strength, pH, ultraviolet exposure etc. Because of its high hydrophilicity, unique three-dimensional network, fine biocompatibility and cell adhesion, hydrogel is one of the suitable biomaterials for drug delivery in antimicrobial areas. In this review, studies from the past 5 years were reviewed, and several types of antimicrobial hydrogels according to different ingredients, different preparations, different antimicrobial mechanisms, different antimicrobial agents they contained and different applications, were summarized. The hydrogels loaded with metal nanoparticles as a potential method to solve antibiotic resistance were highlighted. Finally, future prospects of development and application of antimicrobial hydrogels are suggested.

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“…The inspiration to study the supramolecular self-association of low molecular mass amphiphiles is gaining interest in particular to achieve precise control over the formation of diverse well-defined nanoarchitectures. Vesicles, liposomes, micelles, low molecular weight gels, and other noncovalent aggregates are beautiful manifestations of supramolecular self-assembly that are of topical interest across the scientific disciplines. − These supramolecular aggregates are finding notable applications in different research domain including material science, chemical science, biomedicine, biocatalysis, electronic devices, and others. − In many instances, it was perceived that task specific applications of self-assemblies depend on their morphological identities. − Thus, tuning the morphology of these nanostructures is of great demand, and in particular, fabrication of multistructured self-assemblies from single molecular backbone is highly important. Stimuli sensitive structural transition of supramolecular self-assemblies from single molecular backbone is finding notable importance for developing multishaped nanoarchitectures.…”

Section: Introductionmentioning

confidence: 99%

Solvent Induced Morphological Evolution of Cholesterol Based Glucose Tailored Amphiphiles: Transformation from Vesicles to Nanoribbons

et al. 2016

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Supramolecular self-assembly of low molecular mass amphiphiles is of topical interest with the urge to achieve precise control over the formation of various self-aggregated structures. Particularly, fabrication of multifarious nanostructures from single molecular backbone would be highly advantageous for task specific applications of the self-aggregates. To this end, the present study reports the solvent triggered evolution of hierarchical self-assembled structures of cholesterol based glucose appended amphiphiles and the pathway of structural transition. The amphiphiles formed bilayered vesicles in water and gels in different organic solvents. In DMSO-water solvent mixture, it showed gradual transition in the morphology of self-aggregates from vesicle-to-fiber and intermediate morphologies depending on the solvent compositions. Microscopic and spectroscopic investigations showed that morphological transformation took place through fusion, elongation and twisting of self-aggregates owing to the reorganization of the amphiphiles (H-type to J-type) in varied solvent polarity. Moreover, sheetlike molecular organization originating from hydrogen bonding and solvophobic interaction played a vital role in the formation of nanoribbons that led to the formation of gel fibril network. This study endows a new strategy to develop solvent induced multistructured self-aggregates from a single molecular scaffold, unraveling the route of forming hierarchical self-assembly.

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Supramolecular hydrogels based on antimycobacterial amphiphiles

Cited by 13 publications

References 26 publications

Antibacterial Hydrogels

Antibacterial Hydrogels

Antimicrobial hydrogels: promising materials for medical application

Solvent Induced Morphological Evolution of Cholesterol Based Glucose Tailored Amphiphiles: Transformation from Vesicles to Nanoribbons

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