Supramolecular hydrogels cross-linked by preassembled host–guest PEG cross-linkers resist excessive, ultrafast, and non-resting cyclic compression

Chen, Xiaoyu; Dong, Chaoqun; Wei, Kongchang; Yao, Yifei; Qian, Feng; Zhang, Kunyu; Han, Fengxuan; Mak, Arthur F.T.; Li, Bin; Bian, Liming

doi:10.1038/s41427-018-0071-0

Cited by 55 publications

(37 citation statements)

References 41 publications

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“…The mechanical resilience and rapid recovery abilities of hydrogel implants are critical in load-bearing tissues, such as articular cartilage, which are routinely subjected to cyclic loadings of high magnitude and frequency 211 , 212 . Fortunately, it has been proven that the energy dissipation by the hydrogels can protect the loaded cells.…”

Section: Discussionmentioning

confidence: 99%

“…For example, dynamic single-chain nanogels as building blocks provide effective energy dissipation to bulk hydrogels, thereby protecting the encapsulated stem cells from deleterious mechanical shocks in a 3D matrix 211 . Additionally, PEG-adamantane supramolecular hydrogels exhibit substantial deformability and excellent capacity to dissipate massive amounts of loading energy and have a rapid, full recovery during excessive, ultrafast, and nonresting cyclic compression 212 .…”

Section: Discussionmentioning

confidence: 99%

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Exquisite design of injectable Hydrogels in Cartilage Repair

Chen

Deng

et al. 2020

Theranostics

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Cartilage damage is still a threat to human beings, yet there is currently no treatment available to fully restore the function of cartilage. Recently, due to their unique structures and properties, injectable hydrogels have been widely studied and have exhibited high potential for applications in therapeutic areas, especially in cartilage repair. In this review, we briefly introduce the properties of cartilage, some articular cartilage injuries, and now available treatment strategies. Afterwards, we propose the functional and fundamental requirements of injectable hydrogels in cartilage tissue engineering, as well as the main advantages of injectable hydrogels as a therapy for cartilage damage, including strong plasticity and excellent biocompatibility. Moreover, we comprehensively summarize the polymers, cells, and bioactive molecules regularly used in the fabrication of injectable hydrogels, with two kinds of gelation, i.e., physical and chemical crosslinking, which ensure the excellent design of injectable hydrogels for cartilage repair. We also include novel hybrid injectable hydrogels combined with nanoparticles. Finally, we conclude with the advances of this clinical application and the challenges of injectable hydrogels used in cartilage repair.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Exquisite design of injectable Hydrogels in Cartilage Repair

Chen

Deng

et al. 2020

Theranostics

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“…[57] Another method of generating injectable, physically crosslinking hydrogels is through using host-guest chemistry. [58][59][60][61][62][63][64][65] The most common types of host molecules are cyclodextrin (CD), cucurbituril (CB), and crown ether (CE). They can couple with linear polymers or small guest molecules that are able to fit into the cavity of the host molecules.…”

Section: Physically Crosslinked Injectable Hydrogelsmentioning

confidence: 99%

“…The prepared hydrogel showed enhanced mechanical properties such as substantial deformability, excellent stability to the applied stress, and an ultrafast and nonresting cyclic compression. [62] Feng et al reported injectable gelatin hydrogels physically crosslinked by host-guest complexations that were further reinforced by limited chemical crosslinking (Figure 2). In this respect, photo-crosslinkable acryloyl -cyclodextrin (Ac--CD) was synthesized and physically crosslinked with the aromatic residues of gelatin (e.g., phenylalanine, tyrosine, and tryptophan) via host-guest interactions.…”

Section: Physically Crosslinked Injectable Hydrogelsmentioning

confidence: 99%

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Rizzo

Kehr

2020

Adv Healthcare Materials

222

152

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Injectable hydrogels have received considerable interest in the biomedical field due to their potential applications in minimally invasive local drug delivery, more precise implantation, and site‐specific drug delivery into poorly reachable tissue sites and into interface tissues, where wound healing takes a long time. Injectable hydrogels, such as in situ forming and/or shear‐thinning hydrogels, can be generated using chemically and/or physically crosslinked hydrogels. Yet, for controlled and local drug delivery applications, the ideal injectable hydrogel should be able to provide controlled and sustained release of drug molecules to the target site when needed and should limit nonspecific drug molecule distribution in healthy tissues. Thus, such hydrogels should sense the environmental changes that arise in disease states and be able to release the optimal amount of drug over the necessary time period to the target region. To address this, researchers have designed stimuli‐responsive injectable hydrogels. Stimuli‐responsive hydrogels change their shape or volume when they sense environmental stimuli, e.g., pH, temperature, light, electrical signals, or enzymatic changes, and deliver an optimal concentration of drugs to the target site without affecting healthy tissues.

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“…To synthesize adamantane-capped PEG (Ad-PEG5000-Mal), a 1:1 (w/w) ratio of adamantane carbonyl chloride and maleimide-PEG5000-hydroxyl was dissolved in anhydrous chloroform (5 mL chloroform per 1 g mixture), according to a previous protocol 28 . Equal molar amounts of triethylamine to PEG was then added dropwise and the solution was allowed to react for 24 hrs.…”

Section: Protein-peg-adamantane Conjugation Synthesismentioning

confidence: 99%

Leveraging Affinity Interactions to Prolong Drug Delivery of Protein Therapeutics

Dogan

Dabkowski

Recum

2020

Preprint

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While peptide and protein therapeutics have made tremendous advances in clinical treatments over the past few decades, they have been largely hindered by their ability to be effectively delivered to patients. While bolus parenteral injections have become standard clinical practice, they are insufficient to treat diseases that require sustained, local release of therapeutics. Cyclodextrin-based polymers (pCD) have been utilized as a platform to extend the local delivery of small-molecule hydrophobic drugs by leveraging hydrophobic-driven thermodynamic interactions between pCD and payload to extend its release, which has seen success both in vitro and in vivo. Herein, we proposed the novel synthesis of protein-polymer conjugates that are capped with a “high affinity” adamantane. Using bovine serum albumin as a model protein, and anti-interleukin 10 monoclonal antibodies as a functional example, we outline the synthesis of novel protein-polymer conjugates that, when coupled with cyclodextrin delivery platforms, can maintain a sustained release of up to 65 days without largely sacrificing protein structure/function which has significant clinical applications in local antibody-based treatments for immune diseases, cancers, and diabetes.Graphical Abstract

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Supramolecular hydrogels cross-linked by preassembled host–guest PEG cross-linkers resist excessive, ultrafast, and non-resting cyclic compression

Cited by 55 publications

References 41 publications

Exquisite design of injectable Hydrogels in Cartilage Repair

Exquisite design of injectable Hydrogels in Cartilage Repair

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Leveraging Affinity Interactions to Prolong Drug Delivery of Protein Therapeutics

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