Supramolecular Hydrogels: Design Strategies and Contemporary Biomedical Applications

Omar, Jasmin; Ponsford, Daniel; Dreiss, Cécile A.; Lee, Tung‐Chun; Loh, Xian Jun

doi:10.1002/asia.202200081

Cited by 61 publications

(30 citation statements)

References 243 publications

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“…In the process of peptide self-assembly, the carbonyl and amide groups in the peptide backbone contribute to the formation of hydrogen bonding, which causes the peptides to align in a particular orientation and produce functional nanostructures. Since molecules that rely solely on hydrogen bonding for self-assembly are prone to undergo solution (sol) rather than gelation (gel), most hydrogels assembled by hydrogen bonding are amphiphilic (Omar et al, 2022). In proteins and peptides, hydrogen bonding is essential for the formation of secondary structures and super secondary structures.…”

Section: Hydrogen Bondingmentioning

confidence: 99%

Research progress of self-assembling peptide hydrogels in repairing cartilage defects

Wang

Yang

et al. 2022

Front. Mater.

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Due to the lack of blood vessels, nerves and lymphatic vessels, the capacity of articular cartilage to heal is extremely limited. Once damaged, it is urgent for articular cartilage to repair the injury. In recent years, there has been an increase in cartilage tissue engineering studies. Self-assembling peptide hydrogel as a kind of hydrogels composed of peptides and water is widely used in cartilage tissue engineering. Under noncovalent interactions such as electrostatic interaction, hydrophobic interaction, hydrogen bonding and pi-pi stacking force, peptides self-assemble into three-dimensional (3D) structures that mimic the natural extracellular matrix and allow cells to grow, proliferate and differentiate. Because SAPHs have excellent biocompatibility and biodegradability, variable mechanical properties, low immunogenicity, injectability, and the ability to load cells and bioactive substances, many researchers utilized them to promote the repair and regeneration of articular cartilage after damage. Therefore, the purpose of this review is to sum up the composition, injury characteristics, and treatments of articular cartilage, as well as the action of SAPHs in repairing articular cartilage damage.

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Section: Hydrogen Bondingmentioning

confidence: 99%

Research progress of self-assembling peptide hydrogels in repairing cartilage defects

Wang

Yang

et al. 2022

Front. Mater.

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“…In the construction of a network of supramolecular hydrogels a gelling molecule or macromolecule is necessary to form non-covalent intermolecular dynamic bonds such as hydrogen bonds, van der Waals interactions, electrostatic interactions, hydrophobic interactions, π−π bonds, metal-ligand coordination, and host-guest interactions [4]. In contrast, these properties are much less easily achievable by fully covalently cross-linked hydrogels whose degradation is practically negligible due polymer network is made by strong and irreversible covalent bonds [5].…”

Section: Introductionmentioning

confidence: 99%

Structural Strategies of Supramolecular Hydrogels and Their Applications

Sánchez-Fernández¹

2023

Preprint

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Supramolecular structures are of great interest due to their applicability in various scientific and industrial fields. These fields of scientific action include promising applications i biomedical areas, in sensing, and in conductive and electrical phases. The sensible definition of supramolecular molecules is being set by investigators, who, because of the different sensitivities of their methods and observational timescales, may have different views as to what constitute these supramolecular structures. Besides, diverse polymers can be found to offer unique avenues for multifunctional systems with properties in medicine industrial applications. Aspects of this review provide different conceptual strategies to address molecular design, properties, and potential applications of self-assembly materials and the use of metal coordination as a feasible and useful strategy for constructing complex supramolecular structures. In this order of appreciations and ideas order, it is that this review report involves classic topics such as hydrogels that range from their relationship with drug delivery systems, to metallo-supramolecular materials, through applications in ophthalmic systems, in applications that require adhesiveness and electrically conductive hydrogels. This review also addresses systems that are largely based on hydrogel chemistry and the enormous opportunities to design very specific structures for applications that demand enormous specificity.

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“…In the construction of a network of supramolecular hydrogels, a gelling molecule or macromolecule is necessary to form non-covalent intermolecular dynamic bonds such as hydrogen bonds, van der Waals interactions, electrostatic interactions, hydrophobic interactions, π−π bonds, metal–ligand coordination, and host–guest interactions [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Structural Strategies for Supramolecular Hydrogels and Their Applications

Sánchez-Fernández¹

2023

Polymers

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Supramolecular structures are of great interest due to their applicability in various scientific and industrial fields. The sensible definition of supramolecular molecules is being set by investigators who, because of the different sensitivities of their methods and observational timescales, may have different views on as to what constitutes these supramolecular structures. Furthermore, diverse polymers have been found to offer unique avenues for multifunctional systems with properties in industrial medicine applications. Aspects of this review provide different conceptual strategies to address the molecular design, properties, and potential applications of self-assembly materials and the use of metal coordination as a feasible and useful strategy for constructing complex supramolecular structures. This review also addresses systems that are based on hydrogel chemistry and the enormous opportunities to design specific structures for applications that demand enormous specificity. According to the current research status on supramolecular hydrogels, the central ideas in the present review are classic topics that, however, are and will be of great importance, especially the hydrogels that have substantial potential applications in drug delivery systems, ophthalmic products, adhesive hydrogels, and electrically conductive hydrogels. The potential interest shown in the technology involving supramolecular hydrogels is clear from what we can retrieve from the Web of Science.

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Supramolecular Hydrogels: Design Strategies and Contemporary Biomedical Applications

Cited by 61 publications

References 243 publications

Research progress of self-assembling peptide hydrogels in repairing cartilage defects

Research progress of self-assembling peptide hydrogels in repairing cartilage defects

Structural Strategies of Supramolecular Hydrogels and Their Applications

Structural Strategies for Supramolecular Hydrogels and Their Applications

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