Supramolecular Hydrogels for Regenerative Medicine

Pape, Ach Bram; Dankers, Pyw Patricia

doi:10.1007/978-3-319-15404-6_7

Cited by 7 publications

(7 citation statements)

References 137 publications

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“…Chau, Sriskandha, Thérien-Aubin, and Kumacheva highlight recent progress in the field of nanofibrillar supramolecular gels, discussing both synthetic and natural materials [305], whereas Li and Liu add a particular view on the potential of cellulose and cellulose derivatives for the formation of chemical and physical gels and microgels, with a specific view to supramolecular interactions within them [306]. Finally, Pape and Dankers provide a review on supramolecular hydrogels of several of the preceding kinds for use in the field of regenerative medicine [307].…”

Section: Discussionmentioning

confidence: 97%

Supramolecular Polymer Networks: Preparation, Properties, and Potential

Rossow

Seiffert

2015

Advances in Polymer Science

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Section: Discussionmentioning

confidence: 97%

Supramolecular Polymer Networks: Preparation, Properties, and Potential

Rossow

Seiffert

2015

Advances in Polymer Science

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“…15,16 Although the gelation process can be carried out under mild conditions, the physical hydrogel network typically has weak mechanical strength and shows poor stability in tissues. 17 Here, we briefly overview several common physical gelation methods, including electrostatic interaction (ionic crosslinking), thermally-mediated gelation, and hydrogen bonding.…”

Section: Principle Of Gelationmentioning

confidence: 99%

Cell-laden microfluidic microgels for tissue regeneration

et al. 2016

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Regenerating the diseased tissue is one of the foremost concerns for the millions of patients who suffer from tissue damage each year. Local delivery of cell-laden hydrogels offers an attractive approach for tissue repair. However, due to the typical macroscopic size of these cell constructs, the encapsulated cells often suffer from poor nutrient exchange. These issues can be mitigated by incorporating cells into microscopic hydrogels, or microgels, whose large surface-to-volume ratio promotes efficient mass transport and enhanced cell-matrix interactions. Using microfluidic technology, monodisperse cell-laden microgels with tunable sizes can be generated in a high-throughput manner, making them useful building blocks that can be assembled into tissue constructs with spatially controlled physicochemical properties. In this review, we examine microfluidics-generated cell-laden microgels for tissue regeneration applications. We provide a brief overview of the common biomaterials, gelation mechanisms, and microfluidic device designs that are used to generate these microgels, and summarize the most recent works on how they are applied to tissue regeneration. Finally, we discuss future applications of microfluidic cell-laden microgels as well as existing challenges that should be resolved to stimulate their clinical application.

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“…Fibrillation and hydrogelation from low molecular weight (LMW) compounds is a deeply studied topic in the field of soft matter, for the interesting and high-end applicative perspectives in fields as wide as tissues engineering, pharmacology or art preservation. [1][2][3][4] The large body of work performed in the past three decades has largely focused on the discovery of new LMW hydrogelators and control of the fibrillation and hydrogel properties. [5][6][7][8][9][10][11][12] Only recently, however, the interest began to focus on the relationship between the energy landscapes of a given gelator and its self-assembled structures.…”

Section: Introductionmentioning

confidence: 99%

Energy Landscape of the Sugar Conformation Controls the Sol-to-Gel Transition in Self-Assembled Bola Glycolipid Hydrogels

et al. 2022

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Self-assembled fibrillar network (SAFIN) hydrogels and organogels are commonly obtained by a crystallization process into fibers induced by external stimuli like temperature or pH. The gelto-sol-to-gel transition is generally readily reversible and the change rate of the stimulus determines the fiber homogeneity and eventual elastic properties of the gels. However, recent work shows that in some specific cases, fibrillation occurs for a given molecular conformation and the sol-to-gel transition depends on the relative energetic stability of one conformation over the other, and not on the rate of change of the stimuli. We observe such a phenomenon on a class of bolaform glycolipids, sophorosides, similar to the well-known sophorolipid biosurfactants, but composed of two symmetric sophorose units. A combination of oscillatory rheology, small-angle X-ray scattering (SAXS) cryogenic transmission electron microscopy (cryo-TEM) and in situ rheo-SAXS using synchrotron radiation shows that below 14°C, twisted nanofibers are the thermodynamic phase. Between 14°C and about 33°C, nanofibers coexist with micelles and a strong hydrogel forms, the sol-to-gel transition being readily reversible in this temperature range. However, above the annealing temperature of about 40°C, the micelle morphology becomes kinetically-trapped over hours, even upon cooling, whichever the rate, to 4°C. A combination of solution and solid-state nuclear magnetic resonance (NMR) suggests two different conformations of the 1ˈˈ, 1ˈ and 2ˈ carbon stereocenters of sophorose, precisely at the β(1,2) glycosidic bond, for which several combinations of the dihedral angles are known to provide at least three energetic minima of comparable magnitude and each corresponding to a given sophorose conformation.

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Supramolecular Hydrogels for Regenerative Medicine

Cited by 7 publications

References 137 publications

Supramolecular Polymer Networks: Preparation, Properties, and Potential

Supramolecular Polymer Networks: Preparation, Properties, and Potential

Cell-laden microfluidic microgels for tissue regeneration

Energy Landscape of the Sugar Conformation Controls the Sol-to-Gel Transition in Self-Assembled Bola Glycolipid Hydrogels

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