Supramolecular Integration of Multifunctional Nanomaterial by Mannose-Decorated Azocalixarene with Ginsenoside Rb1 for Synergistic Therapy of Rheumatoid Arthritis

Li, Shihui; Li, Juan-Juan; Zhao, Ying-Ying; Chen, Meng-Meng; Su, Shan-Shan; Yao, Shun-Yu; Wang, Ze-Han; Hu, Xin-Yue; Geng, Wen-Chao; Wang, Wei; Wang, Ke-Rang; Guo, Dong-Sheng

doi:10.1021/acsnano.3c09140

Cited by 8 publications

(1 citation statement)

References 69 publications

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“…Our work on the construction of multifunctional materials using amphiphilic calixarenes for the treatment of rheumatoid arthritis serves as a testament to this point. 136 …”

Section: Discussionmentioning

confidence: 99%

Supramolecular interaction in the action of drug delivery systems

Geng,

Jiang,

Chen

et al. 2024

Chem. Sci.

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“…Our work on the construction of multifunctional materials using amphiphilic calixarenes for the treatment of rheumatoid arthritis serves as a testament to this point. 136 …”

Section: Discussionmentioning

confidence: 99%

Supramolecular interaction in the action of drug delivery systems

Geng,

Jiang,

Chen

et al. 2024

Chem. Sci.

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Broad‐Spectrum Detoxification of Snake Venoms With Supramolecular Materials Integrated via Molecular Recognition and Coassembly

Chen,

Tian,

Cheng

et al. 2024

Adv Healthcare Materials

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Snakebite is a medical emergency that often leads to high mortality and morbidity in tropical and subtropical regions. The diversity in venom composition between various types of snakes necessitates the use of different specific antivenom treatments, which presents clinical and financial challenges in the management of snakebites. Therefore, developing a broad‐spectrum antidote to neutralize complex and diverse snake venoms has assumed critical importance. Herein, a broad‐spectrum antidote is developed through molecular recognition and coassembly to neutralize four kinds of snake venom toxins, those are three‐finger toxin (3FTx), snake venom metalloproteinase (SVMP), phospholipase A2 (PLA2), and snake venom serine protease (SVSP), which have high abundance and toxicity. The coassembly of sulfonate‐modified amphiphilic calixarene (SCA) and amphiphilic cyclodextrin (CD) is employed to neutralize the toxicity of 3FTx, 1,2‐dodecanedithiol (DDT) and thioetheramide phosphorylcholine (TEAPC) are introduced through coassembly to neutralize toxicity of SVMP and PLA2, respectively, and the nafamostat (NT), which can be loaded through the host‐guest complexation, is employed to neutralize toxicity of SVSP. The broad‐spectrum antidote, NT@SCA/CD/DDT/TEAPC, effectively neutralizes key toxins from the most medically important cobra and vipers, significantly improving survival rates of poisoned mice. This study conceptually validated the feasibility of broad‐spectrum detoxification and also offers a conveniently integrated supramolecular strategy.

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Co‐Assembled Nanoparticles toward Multi‐Target Combinational Therapy of Alzheimer's Disease by Making Full Use of Molecular Recognition and Self‐Assembly

Li,

Xu,

Wang

et al. 2024

Advanced Materials

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The complex pathologies in Alzheimer's disease (AD) severely limits the effectiveness of single‐target pharmic interventions, thus necessitating multi‐pronged therapeutic strategies. While flexibility is essentially demanded in constructing such multi‐target systems, for achieving optimal synergies and also accommodating the inherent heterogeneity within AD. Utilizing the dynamic reversibility of supramolecular strategy for conferring sufficient tunability in component substitution and proportion adjustment, amphiphilic calixarenes are poised to be a privileged molecular tool for facilely achieving function integration. Herein, taking β‐amyloid (Aβ) fibrillation and oxidative stress as model combination pattern, we proposed a supramolecular multifunctional integration by co‐assembling guanidinium‐modified calixarene with ascorbyl palmitate and loading dipotassium phytate within calixarene cavity. Serial pivotal events can be simultaneously addressed by this versatile system, including (1) inhibition of Aβ production and aggregation, (2) disintegration of Aβ fibrils, (3) acceleration of Aβ metabolic clearance, and (4) regulation of oxidative stress, which is verified to significantly ameliorate the cognitive impairment of 5×FAD mice, with reduced Aβ plaque content, neuroinflammation and neuronal apoptosis. Confronted with the extremely intricate clinical realities of AD, the strategy presented here exhibits ample adaptability for necessary alterations on combinations, thereby may immensely expedite the advancement of AD combinational therapy through providing an exceptionally convenient platform.This article is protected by copyright. All rights reserved

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Supramolecular Integration of Multifunctional Nanomaterial by Mannose-Decorated Azocalixarene with Ginsenoside Rb1 for Synergistic Therapy of Rheumatoid Arthritis

Cited by 8 publications

References 69 publications

Supramolecular interaction in the action of drug delivery systems

Supramolecular interaction in the action of drug delivery systems

Broad‐Spectrum Detoxification of Snake Venoms With Supramolecular Materials Integrated via Molecular Recognition and Coassembly

Co‐Assembled Nanoparticles toward Multi‐Target Combinational Therapy of Alzheimer's Disease by Making Full Use of Molecular Recognition and Self‐Assembly

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