Supramolecular interactions of oxidative stress biomarker glutathione with fluorone black

Hepel, Maria; Stobiecka, Magdalena

doi:10.1016/j.saa.2017.11.017

Cited by 14 publications

(9 citation statements)

References 37 publications

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“…The appearance of ROS, generated in mitochondria, was detected 30 min after the AMF application. These experiments show that using MNPs stimulated with HF-AMF, it becomes possible to generate ROS in targeted cancer cells, mitigating collateral damage to healthy cells as well as reversing drug resistance established by overexpression of GSH in cancer cells in response to oxidative stress [41,104,105] introduced by chemotherapeutic drugs.…”

Section: Magnetically Guided Mnps For Ros Generation and Cancer Treatmentmentioning

confidence: 82%

Magnetic Nanoparticles for Nanomedicine

Hepel

2020

Magnetochemistry

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The field of nanomedicine has recently emerged as a product of the expansion of a range of nanotechnologies into biomedical science, pharmacology and clinical practice. Due to the unique properties of nanoparticles and the related nanostructures, their applications to medical diagnostics, imaging, controlled drug and gene delivery, monitoring of therapeutic outcomes, and aiding in medical interventions, provide a new perspective for challenging problems in such demanding issues as those involved in the treatment of cancer or debilitating neurological diseases. In this review, we evaluate the role and contributions that the applications of magnetic nanoparticles (MNPs) have made to various aspects of nanomedicine, including the newest magnetic particle imaging (MPI) technology allowing for outstanding spatial and temporal resolution that enables targeted contrast enhancement and real-time assistance during medical interventions. We also evaluate the applications of MNPs to the development of targeted drug delivery systems with magnetic field guidance/focusing and controlled drug release that mitigate chemotherapeutic drugs’ side effects and damage to healthy cells. These systems enable tackling of multiple drug resistance which develops in cancer cells during chemotherapeutic treatment. Furthermore, the progress in development of ROS- and heat-generating magnetic nanocarriers and magneto-mechanical cancer cell destruction, induced by an external magnetic field, is also discussed. The crucial roles of MNPs in the development of biosensors and microfluidic paper array devices (µPADs) for the detection of cancer biomarkers and circulating tumor cells (CTCs) are also assessed. Future challenges concerning the role and contributions of MNPs to the progress in nanomedicine have been outlined.

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Section: Magnetically Guided Mnps For Ros Generation and Cancer Treatmentmentioning

confidence: 82%

Magnetic Nanoparticles for Nanomedicine

Hepel

2020

Magnetochemistry

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“…Глутатион -один из важных факторов антиоксидантной защиты (32, 33) и критических маркеров оценки ее функционирования (34,35). После 5-суточной иммобилизации кроликов концентрация восстановленного глутатиона в I группе была на 35 % ниже, чем во II (p  0,02), на 50 % (p  0,01) -по сравнению с III, на 60 % (p  0,01) и 70 % (p  0,01) -соответственно с IV и V группами (см.…”

Section: показатели системы антиоксидантной защиты крови и динамика жunclassified

DYNAMICS OF OXIDATIVE STATE INDICATORS IN RABBITS (Oryctolagus cuniculus L.) UNDER SIMULATED TECHNOLOGICAL STRESS AND ITS PHARMACOLOGICAL CORRECTION

Киреев¹,

Оробец²,

Denisenko³

et al. 2019

s-h. biol.

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“…The CDD system may also serve as an efficient vehicle to overcome MDR [6,7,10], which is challenging due to the involvement of alterations in several signaling pathways. MDR is acquired by tumors as a protection against reactive oxygen species (ROS), the main weapon of the organism to fight cancer [22][23][24][25], by overexpressing anti-apoptotic proteins and glutathione (GSH) [26,27], able to neutralize highly active radicals of ROS. Due to MDR, an increased dose of chemotherapeutic agents is necessary to overcome drug resistance, inevitably leading to increased collateral damage to healthy cells.…”

Section: Introductionmentioning

confidence: 99%

Cancer-Targeted Controlled Delivery of Chemotherapeutic Anthracycline Derivatives Using Apoferritin Nanocage Carriers

Kurzątkowska

Pazos

Herschkowitz

et al. 2021

IJMS

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The interactions of chemotherapeutic drugs with nanocage protein apoferritin (APO) are the key features in the effective encapsulation and release of highly toxic drugs in APO-based controlled drug delivery systems. The encapsulation enables mitigating the drugs’ side effects, collateral damage to healthy cells, and adverse immune reactions. Herein, the interactions of anthracycline drugs with APO were studied to assess the effect of drug lipophilicity on their encapsulation excess n and in vitro activity. Anthracycline drugs, including doxorubicin (DOX), epirubicin (EPI), daunorubicin (DAU), and idarubicin (IDA), with lipophilicity P from 0.8 to 15, were investigated. We have found that in addition to hydrogen-bonded supramolecular ensemble formation with n = 24, there are two other competing contributions that enable increasing n under strong polar interactions (APO(DOX)) or under strong hydrophobic interactions (APO(IDA) of the highest efficacy). The encapsulation/release processes were investigated using UV-Vis, fluorescence, circular dichroism, and FTIR spectroscopies. The in vitro cytotoxicity/growth inhibition tests and flow cytometry corroborate high apoptotic activity of APO(drugs) against targeted MDA-MB-231 adenocarcinoma and HeLa cells, and low activity against healthy MCF10A cells, demonstrating targeting ability of nanodrugs. A model for molecular interactions between anthracyclines and APO nanocarriers was developed, and the relationships derived compared with experimental results.

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Supramolecular interactions of oxidative stress biomarker glutathione with fluorone black

Cited by 14 publications

References 37 publications

Magnetic Nanoparticles for Nanomedicine

Magnetic Nanoparticles for Nanomedicine

DYNAMICS OF OXIDATIVE STATE INDICATORS IN RABBITS (Oryctolagus cuniculus L.) UNDER SIMULATED TECHNOLOGICAL STRESS AND ITS PHARMACOLOGICAL CORRECTION

Cancer-Targeted Controlled Delivery of Chemotherapeutic Anthracycline Derivatives Using Apoferritin Nanocage Carriers

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