Supramolecular medical antibacterial tissue adhesive prepared based on natural small molecules

Abstract

In the field of biomedicine, tissue bio-adhesives require the use of polymer materials with integrated functions to meet changing practical applications. However, the currently available tissue glue cannot balance mechanical...

Renewable and recyclable covalent adaptable networks based on bio-derived lipoic acid

“…Moreover, our disulfide network was stable under ambient conditions without any further treatment. Previous studies have noted poor stability for polydisulfides unless the propagating thiolate species is protonated 33 , quenched with an electrophile 31 or the thiyl radical chain-end is reacted with a capping agent 41,[46][47][48] to form a new S-C bond. However, in our system we only employ 1 mol% base (relative to the disulfide) so not all crosslink sites could be expected to be in their ringopened thiolate form which may explain the observed behaviour here.…”

“…ROP) and then crosslinking the material via metal coordination/complexation of the carboxylate moiety. [40][41][42][43][44][45][46] Other studies have also modified the carboxylic acid of lipoic acid with dopamine 47 or N-hydroxy succinimide 48 to produce self-healing supramolecular adhesives. Additionally, dynamic cyclic disulfides have also featured in degradable nanoparticles 49,50 and adaptable hydrogels [51][52][53][54] , although in the gel examples the disulfide features as a reactive polymer a.…”

Engineering Hydrogel Adhesion for Biomedical Applications via Chemical Design of the Junction

“…A similar mechanism was used to design adhesives with polyethylenimine-based gels (PEI) 50 and thioctic acid/PEGDA. 132,133 Tough alginate−PAAm (Alg−PAAm) gels were glued to tissues with a variety of amine-containing bridging polymers or glues including chitosan, polyallylamine, polyethylenimine, collagen, and gelatin. 1,75 Covalent bonds were formed between the −COOH groups present on the tissue and on the alginate and the −NH 2 groups of the glue.…”

“…Duraseal is a bonding agent for biological tissues and is based on two components: a four-arm 20 kDa star PEG functionalized with NHS-esters and trilysine, a multifunctional polypeptide. , Amide bond formation between −NH 2 and NHS-activated esters cross-links the PEG gel and grafts it onto tissue amines with adhesion energies in the range of ∼10 J m –2 . A similar mechanism was used to design adhesives with polyethylenimine-based gels (PEI) and thioctic acid/PEGDA. , …”

A hyperbranched polymer-based water-resistant adhesive: Durable underwater adhesion and primer for anchoring anti-fouling hydrogel coating

“…Adhesives are widely used in engineering [1,2], biomedicine [3,4] and daily life [5,6]. However, underwater adhesion is technically challenging, because water molecules may penetrate the adhesion interface to form a hydration film [7,8] in wet environment, which prevents the sufficient contact of adhesive with substrate surface.…”