Supramolecular Metallo‐Bioadhesive for Minimally Invasive Use

Hong, Seonki; Pirovich, David; Kilcoyne, Aoife; Huang, Chen; Lee, Hakho; Weissleder, Ralph

doi:10.1002/adma.201602606

Cited by 70 publications

(48 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The result indicated that introducing catecholFe coordinate bonds can help hydrogel to better dissipate energy. [ 28 ] As the catecholFe coordinate bond can be quickly dissociated after adding the medical Fe chelating agent DFO (Figure 2g), [ 22 ] the PL‐Cat/Fe/ODex hydrogel was next placed into a DFO solution to investigate the hydrogel's degradation. As expected, the PL‐Cat/Fe/ODex hydrogel can be totally dissolved in about 60 min (Figure 2h,i).…”

Section: Resultsmentioning

confidence: 99%

“…The unique feature of dynamic bonds, reversible breakage and reformation, [ 21 ] was expected to endow the hydrogel with the dissolution and repeatable adhesiveness properties. First, the dynamic bond can be quickly dissociated after imparting the proper external stimuli, [ 21,22 ] which can endow the hydrogel with the on‐demand dissolution property. In addition, when the closed wounds are reopened due to the breakage of the hydrogel by accidental tension, the reformation of the dynamic bond was able to allow the self‐healing of the hydrogel thus repeatedly closing the wounds.…”

Section: Introductionmentioning

confidence: 99%

“…CatecholFe bond is a pH‐sensitive coordinate bond with three coordinate types and it can be quickly dissociated upon adding an iron chelating agent such as deferoxamine mesylate (DFO). [ 22 ] Schiff's base bond is a dynamic covalent bond that is widely employed in self‐healing materials. [ 21,23 ] Additionally, the catechol and aldehyde groups used in the formation of these two bonds have been reported to improve the tissue adhesion capacity via multiple non‐covalent and covalent interactions.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bioinspired Double‐Dynamic‐Bond Crosslinked Bioadhesive Enables Post‐Wound Closure Care

Chen

et al. 2020

Adv Funct Materials

144

122

View full text Add to dashboard Cite

Most existing bioadhesives, even those showing superiority in wound closure effectiveness, do not assist in the post-wound closure process. A bioinspired, in situ formed, double-dynamic-bond crosslinked hydrogel bioadhesive that is capable of efficiently closing open wounds and enabling post-wound closure care is reported. Catechol-modified ε-poly-l-lysine and oxidized dextran are employed as natural polymer backbones and they are in situ crosslinked using Schiff 's base dynamic bond and catecholFe coordinate dynamic bond through a process inspired by that used to cure marine mussel glue, forming a hydrogel bioadhesive. The unique double-dynamic-bond crosslinked structure endows the bioadhesive with higher mechanical and adhesive strength while retaining quick dissociation and good self-healing capacities. Accordingly, the bioadhesive can exhibit multiple desirable functions, such as dissolution on demand, repeatable adhesiveness, adhesive and mechanical strength sufficient for wound closure, injectability, and good biocompatibility (DREAMING). After efficiently closing skin incisions, the bioadhesive can be facilely removed or repeatedly close the reopened wounds, thus enabling post-wound closure care. On the basis of favorable functions in wound closure and the ability to enable post-wound closure care, the bioadhesive demonstrates great potential in dealing with skin wounds.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bioinspired Double‐Dynamic‐Bond Crosslinked Bioadhesive Enables Post‐Wound Closure Care

Chen

et al. 2020

Adv Funct Materials

144

122

View full text Add to dashboard Cite

show abstract

“…Inspired by the unusual ability of mussels to adhere to essentially any surfaces under water, extensive studies in the past few decades suggest that the presence of catechol motifs contributes to improved adhesion. 22,23 Since then, mussel-inspired biomaterials have been extensively studied for various applications, including developing a general coating strategy, 24 designing strong adhesives under wet conditions, 25,26 and fabricating hybrid composite nanoparticles, 27 among many others. 28–30 In particular, mussel-inspired hydrogels have been demonstrated to possess unique properties, such as being highly adhesive, self-healing, pollutant absorbing, and antifouling.…”

Section: Introductionmentioning

confidence: 99%

Mussel-Inspired Multifunctional Hydrogel Coating for Prevention of Infections and Enhanced Osteogenesis

Cheng

Yue

Kazemzadeh-Narbat

et al. 2017

ACS Appl. Mater. Interfaces

224

125

View full text Add to dashboard Cite

Prevention of postsurgery infection and promotion of biointegration are the key factors to achieve long-term success in orthopedic implants. Localized delivery of antibiotics and bioactive molecules by the implant surface serves as a promising approach toward these goals. However, previously reported methods for surface functionalization of the titanium alloy implants to load bioactive ingredients suffer from time-consuming complex processes and lack of long-term stability. Here, we present the design and characterization of an adhesive, osteoconductive, and antimicrobial hydrogel coating for Ti implants. To form this multifunctional hydrogel, a photo-cross-linkable gelatin-based hydrogel was modified with catechol motifs to enhance adhesion to Ti surfaces and thus promote coating stability. To induce antimicrobial and osteoconductive properties, a short cationic antimicrobial peptide (AMP) and synthetic silicate nanoparticles (SNs) were introduced into the hydrogel formulation. The controlled release of AMP loaded in the hydrogel demonstrated excellent antimicrobial activity to prevent biofilm formation. Moreover, the addition of SNs to the hydrogel formulation enhanced osteogenesis when cultured with human mesenchymal stem cells, suggesting the potential to promote new bone formation in the surrounding tissues. Considering the unique features of our implant hydrogel coating, including high adhesion, antimicrobial capability, and the ability to induce osteogenesis, it is believed that our design provides a useful alternative method for bone implant surface modification and functionalization.

show abstract

“…Figure A exhibits that gelation occurs after adding Fe 3+ for all ratios of HPAE–Py/Geln liquid mixtures, and the curing time can be adjusted by the concentration of HPAE–Py polymer. For Geln alone, complexation could still be formed through coordination of COOH, NH 2 , and OH groups with Fe 3+ within 30 s, which resulted in a solely physical crosslinked hydrogel. While with increasing content of HPAE–Py, the curing time decreased to 9.0 ± 1.2 s for HPAE–Py (50%)/Geln due to rapid formation of more crosslinking points.…”

mentioning

confidence: 99%

Paintable and Rapidly Bondable Conductive Hydrogels as Therapeutic Cardiac Patches

et al. 2018

View full text Add to dashboard Cite

In recent years, cardiac patches have been developed for the treatment of myocardial infarction. However, the fixation approaches onto the tissue through suture or phototriggered reaction inevitably cause new tissue damage. Herein, a paintable hydrogel is constructed based on Fe -triggered simultaneous polymerization of covalently linked pyrrole and dopamine in the hyperbranched chains where the in situ formed conductive polypyrrole also uniquely serves to crosslink network. This conductive and adhesive hydrogel can be conveniently painted as a patch onto the heart surface without adverse liquid leakage. The functional patch whose conductivity is equivalent to that of normal myocardium is strongly bonded to the beating heart within 4 weeks, accordingly efficiently boosting the transmission of electrophysiological signals. Eventually, the reconstruction of cardiac function and revascularization of the infarct myocardium are remarkably improved. The translatable suture-free strategy reported in this work is promising to address the human clinical challenges in cardiac tissue engineering.

show abstract

Supramolecular Metallo‐Bioadhesive for Minimally Invasive Use

Abstract: Graphical abstract

Cited by 70 publications

References 30 publications

Bioinspired Double‐Dynamic‐Bond Crosslinked Bioadhesive Enables Post‐Wound Closure Care

Bioinspired Double‐Dynamic‐Bond Crosslinked Bioadhesive Enables Post‐Wound Closure Care

Mussel-Inspired Multifunctional Hydrogel Coating for Prevention of Infections and Enhanced Osteogenesis

Paintable and Rapidly Bondable Conductive Hydrogels as Therapeutic Cardiac Patches

Contact Info

Product

Resources

About