Supramolecular nanoparticles constructed by orthogonal assembly of pillar[5]arene-cyclodextrin dimacrocycle for chemo-photodynamic combination therapy

Yin, Yongfei; Sun, Penghao; Dong, Hongqiang; Chen, Yi; Chen, Shigui; Wang, Lu

doi:10.1016/j.cclet.2023.108594

Cited by 14 publications

(2 citation statements)

References 71 publications

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“…Supramolecular chemistry provides a promising avenue to realize combination therapy due to the advantages of supramolecular materials, including reversibility, stimulus-response, self-healing, and modularity. − Recently, macrocycle-based supramolecular biomaterials have been engaged in combination therapy. − Macrocycle-based delivery systems demonstrated noteworthy advantages in precise proportional loading and synchronized release of multiple drugs. The properties are crucial for maximizing synergistic efficacy by leveraging the quantified binding constant of guest encapsulation in atomically precise cavitiesa formidable challenge for other delivery platforms. , Furthermore, host–guest complexation offers a useful strategy for ameliorating the issues of antagonism, instability, and pharmacokinetic differences among multiple drugs, which overcomes the limitations of conventional covalent modification of drugs.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular 3 in 1: A Lubrication and Co-Delivery System for Synergistic Advanced Osteoarthritis Therapy

Chen,

Li,

Zhu

et al. 2024

ACS Nano

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The complexity, heterogeneity, and drug resistance of diseases necessitate a shift in therapeutic paradigms from monotherapy to combination therapy, which could augment treatment efficiency. Effective treatment of advanced osteoarthritis (OA) requires addressing three key factors contributing to its deterioration: chronic joint inflammation, lubrication dysfunction, and cartilagetissue degradation. Herein, we present a supramolecular nanomedicine of multifunctionality via molecular recognition and selfassembly. The employed macrocyclic carrier, zwitterion-modified cavitand (CV-2), not only accurately loads various drugs but also functions as a therapeutic agent with lubricating properties for the treatment of OA. Kartogenin (KGN), a drug for articular cartilage regeneration and protection, and flurbiprofen (FP), an antiinflammatory agent, were coloaded onto CV-2 assembly, forming a supramolecular nanomedicine KGN&FP@CV-2. The three-in-one combination therapy of KGN&FP@CV-2 addresses the three pathological features for treating OA collectively, and thus provides long-term therapeutic benefits for OA through sustained drug release and intrinsic lubrication in vivo. The multifunctional integration of macrocyclic delivery and therapeutics provides a simple, flexible, and universal platform for the synergistic treatment of diseases involving multiple drugs.

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Section: Introductionmentioning

confidence: 99%

Supramolecular 3 in 1: A Lubrication and Co-Delivery System for Synergistic Advanced Osteoarthritis Therapy

Chen,

Li,

Zhu

et al. 2024

ACS Nano

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“…50–58 The electron-rich inner cavity of pillararenes (P[ n ]A) gave them a high host–guest binding ability, thus providing them with excellent loading potential. 59 Therefore, the construction of a pillararene-based supramolecular nanoplatform by host–guest interaction would provide a versatile and promising strategy to intelligently combine multimodal therapies for efficient cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

A supramolecular nanoplatform for imaging-guided phototherapies via hypoxia tumour microenvironment remodeling

Zhou,

Chen,

Ouyang

et al. 2023

Chem. Sci.

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Polymorphic Supramolecular Therapeutic Platforms with Precise Dye/Drug Ratio to Perform Synergistic Chemo‐Photo Anti‐Tumor Therapy and Long‐Term Immune Protection

Yan,

Wang,

Zhao

et al. 2024

Adv Healthcare Materials

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Malignant tumor has become one of the hellish killers threatening the health of people around the world, its diagnosis and treatment has become the concerns of public. However, the optimal therapeutic dose, undesired side‐effect, and long‐term immune activation were key and bottleneck problems in tumor treatment. Herein, different batches of supramolecular therapeutic platforms, including vesicles, spherical nanoparticles, and cylindrical nanorods, with precise ratios of dye to drug (1:2) and multiple stimulus responsiveness were constructed by host‐guest complexation between cyanine‐camptothecin conjugates (IR780‐CPT2) and β‐cyclodextrin (β‐CD) pendent hydrophilic copolymers. The reduction responsiveness, near‐infrared photothermal conversion and singlet oxygen (1O2) generation performances endowed these platforms excellent cancer cells killing effect in both of in vitro cellular experiments and in vivo mice models. More importantly, without affecting the weight of mice, the maturation of dendritic cells, proliferation of T cells, up‐regulation of high mobility group protein B1, and reduction of immunosuppressive regulatory T cells were detected after employing a synergistic chemo‐photo therapy, demonstrating the body's immune effect was successfully activated. Thus, during the treatment of primary tumor, the distal tumor was also inhibited. We believe this work could provide a distinctive way to fabricate supramolecular theranostic platforms with different morphologies and improve antitumor and antimetastasis capabilities.

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Supramolecular nanoparticles constructed by orthogonal assembly of pillar[5]arene-cyclodextrin dimacrocycle for chemo-photodynamic combination therapy

Cited by 14 publications

References 71 publications

Supramolecular 3 in 1: A Lubrication and Co-Delivery System for Synergistic Advanced Osteoarthritis Therapy

Supramolecular 3 in 1: A Lubrication and Co-Delivery System for Synergistic Advanced Osteoarthritis Therapy

A supramolecular nanoplatform for imaging-guided phototherapies via hypoxia tumour microenvironment remodeling

Polymorphic Supramolecular Therapeutic Platforms with Precise Dye/Drug Ratio to Perform Synergistic Chemo‐Photo Anti‐Tumor Therapy and Long‐Term Immune Protection

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