Supramolecular Nanostructures Based on Cyclodextrin and Poly(ethylene oxide): Syntheses, Structural Characterizations and Applications for Drug Delivery

Abstract

Cyclodextrins (CDs) have been extensively studied as drug delivery carriers through host-guest interactions. CD-based poly(pseudo)rotaxanes, which are composed of one or more CD rings threading on the polymer chain with or without bulky groups (or stoppers), have attracted great interest in the development of supramolecular biomaterials. Poly(ethylene oxide) (PEO) is a water-soluble, biocompatible polymer. Depending on the molecular weight, PEO can be used as a plasticizer or as a toughening agent. Moreover, the hydrogels of PEO are also extensively studied because of their outstanding characteristics in biological drug delivery systems. These biomaterials based on CD and PEO for controlled drug delivery have received increasing attention in recent years. In this review, we summarize the recent progress in supramolecular architectures, focusing on poly(pseudo)rotaxanes, vesicles and supramolecular hydrogels based on CDs and PEO for drug delivery. Particular focus will be devoted to the structures and properties of supramolecular copolymers based on these materials as well as their use for the design and synthesis of supramolecular hydrogels. Moreover, the various applications of drug delivery techniques such as drug absorption, controlled release and drug targeting based CD/PEO supramolecular complexes, are also discussed.

Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir

“…Thus, the aim The addition of hydrophilic polymers to cyclodextrin (CD) solutions has been proposed as an opportunity to intensify the inclusion complex formation, improve the solubilizing capability, and modulate drug diffusion [16,17]. Nevertheless, some block copolymers can also penetrate in the CD cavity, forming necklace-like supramolecular structures, named polypseudorotaxanes, that can notably alter both the CD ability to solubilize drug and the sol-gel transition of the block copolymer [18,19]. In general, polypseudorotaxanes of block copolymers with αCD lead to semicrystalline 3D assemblies in which the PEO blocks are encapsulated in the αCD units and form reversible gels at much lower concentration than that required by the copolymer alone [20].…”

Highly Enhanced Curcumin Delivery Applying Association Type Nanostructures of Block Copolymers, Cyclodextrins and Polycyclodextrins

“…The added poly-β-CD however, results in sustained drug release from the Pluronic micellar system which is especially observable after 4 hours. The PEO chains of the Pluronic 105 may form a host:guest complex with the cyclodextrin ring thus slowing the release the of encapsulated curcuminin the core of the micelle [ 50 , 51 ].…”

Click regulation of cyclodextrin primary face for the preparation of novel chiral stationary phases

“…Most enantiomers exhibit completely different bioactivities, toxicities, metabolisms, and drug qualities, wherefore effective chiral separation is essential for obtaining enantiomerically pure chiral compounds. CDs, the second generation of host compounds which is a significant part of supramolecular chemistry . Because CDs are made up of 6∼8 D ‐glucoses connected by α −1,4−glycosidic bonds which cannot rotate , they have truncated cone shaped stereochemical structures with a hydrophobic cavity .…”