Supramolecular polyelectrolyte complexes based on cyclodextrin-grafted chitosan and carrageenan for controlled drug release

Evangelista, Thamasia Fernanda de Sá; Andrade, George Ricardo Santana; Nascimento, Keyte N.S.; Santos, Samuel Bruno dos; Santos, Maria de Fátima Costa; D’Oca, Caroline Da Ros Montes; Estevam, Charles dos Santos; Gimenez, Iara F.; Almeida, Luís Eduardo

doi:10.1016/j.carbpol.2020.116592

Cited by 34 publications

(8 citation statements)

References 60 publications

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“…CS bearing cyclodextrin pendants have been developed for improved applications such as drug delivery, cosmetics, and analytical chemistry [13]. Evangelista et al [42] prepared supramolecular polyelectrolyte complexes (SPEC) based on a cyclodextrin-grafted CS derivative and carrageenan and evaluated them for controlled release of a model drug silver sulfadiazine. In vitro tests have shown a clear bacterial activity toward Gram-positive Bacteria Staphylococcus aureus and Enterococcus durans/hirae and Gram-negative bacteria Klebsiella pneumoniae and Escherichia coli.…”

Section: Chitosan Derivatives With Cyclic Structuresmentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

299

120

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Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

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Section: Chitosan Derivatives With Cyclic Structuresmentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

299

120

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“…Furthermore, Evangelista et al also synthesized supramolecular polyelectrolyte complexes based on the interactions between the positivelycharged -NH 3 + groups of the β-cyclodextrin-grafted chitosan and the negatively-charged -SO 3 groups of the carrageenan for antimicrobial applications. Specifically, β-cyclodextrin was used owing to its possibility to form host-guest inclusion complexes with the silver sulfadiazine molecules that will release silver ions against bacterial cells [117]. Another study by Walvekar et al investigated the antibacterial effects of hyaluronic acid-oleylamine conjugates with different degrees of conjugation as drug nanocarriers against methicillin-resistant S. aureus.…”

Section: Antibacterial Nanoparticlesmentioning

confidence: 99%

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

et al. 2021

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Despite the many advancements in the pharmaceutical and medical fields and the development of numerous antimicrobial drugs aimed to suppress and destroy pathogenic microorganisms, infectious diseases still represent a major health threat affecting millions of lives daily. In addition to the limitations of antimicrobial drugs associated with low transportation rate, water solubility, oral bioavailability and stability, inefficient drug targeting, considerable toxicity, and limited patient compliance, the major cause for their inefficiency is the antimicrobial resistance of microorganisms. In this context, the risk of a pre-antibiotic era is a real possibility. For this reason, the research focus has shifted toward the discovery and development of novel and alternative antimicrobial agents that could overcome the challenges associated with conventional drugs. Nanotechnology is a possible alternative, as there is significant evidence of the broad-spectrum antimicrobial activity of nanomaterials and nanoparticles in particular. Moreover, owing to their considerable advantages regarding their efficient cargo dissolving, entrapment, encapsulation, or surface attachment, the possibility of forming antimicrobial groups for specific targeting and destruction, biocompatibility and biodegradability, low toxicity, and synergistic therapy, polymeric nanoparticles have received considerable attention as potential antimicrobial drug delivery agents. In this context, the aim of this paper is to provide an up-to-date overview of the most recent studies investigating polymeric nanoparticles designed for antimicrobial therapies, describing both their targeting strategies and their effects.

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“…In addition, there are some findings that the addition of β-cyclodextrin to the chitosan hydrogel improves the pH, gelling, viscosity, and drug release behavior of the hydrogel [26]. Several studies have been published on the delivery of antiviral, cardiovascular, and antibiotic drugs via β-cyclodextrin-based hydrogels [27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Tenofovir Disoproxil Fumarate Release From Glutaraldehyde Cross-Linked Chitosan/Β-Cyclodextrin Hydrogel

Yaman,

Erdogan,

Taşdelen

2024

Hacettepe Journal of Biology and Chemistry

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In this study, chitosan was produced from crayfish Astacus leptodactylus, and then it was used to synthesize chitosan-graft-β-cyclodextrin (CS-g-β-CD) hydrogel. The produced chitosan (CS) and the sythesized CS-g-β-CD hydrogel were characterized using a Fourier Transform Infrared Spectroscopy (FTIR), Proton Nuclear Magnetic Resonance Spectroscopy (1H-NMR), X-ray Diffraction (XRD), and Scanning Electron Microscopy (SEM). Tenofovir disoproxil fumarate (TDF) was used as a model to investigate the antiviral drug release properties of the CS-g-β-CD hydrogel. The synthesized hydrogel had an almost homogeneous pore structure and a high swelling capacity which increases depending on the amount of β-Cyclodextrin (β-CD). The drug-loaded CS-g-β-CD hydrogels was examined by XRD and 1H-NMR, and SEM analyses. Seventy-three percent of the TDF loaded on the synthesized hydrogels was released into phosphate-buffered saline (PBS) solution at 37 ºC. The drug release behavior of all prepared CS-g-β-CD hydrogels fitted the Korsmeyer-Peppas model. The addition of β-CD into the gel improved the swelling ability and TDF release of the CS-g-β-CD hydrogel system.

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Supramolecular polyelectrolyte complexes based on cyclodextrin-grafted chitosan and carrageenan for controlled drug release

Cited by 34 publications

References 60 publications

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

Tenofovir Disoproxil Fumarate Release From Glutaraldehyde Cross-Linked Chitosan/Β-Cyclodextrin Hydrogel

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