Supramolecular polymersomes constructed from water-soluble pillar[5]arene and cationic poly(glutamamide)s and their applications in targeted anticancer drug delivery

Guo, Shuwen; Liang, Tingxizi; Song, Yongshang; Cheng, Ming; Hu, Xiao‐Yu; Zhu, Jun‐Jie; Wang, Leyong

doi:10.1039/c7py01259d

Cited by 47 publications

(16 citation statements)

References 31 publications

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“…The Du group prepared 40 which, as the polyanion, formed pseudorotaxanes on the surface of MSNs filled with DOX and coated with quaternary ammonium or pyridinium groups . Cargo release was triggered by Zn 2+ , acidic conditions or paraquat.…”

Section: Medical Applicationsmentioning

confidence: 99%

Pillar[n]arenes at the Chemistry‐Biology Interface

Cragg

2018

Israel Journal of Chemistry

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Macrocyclic chemistry has provided chemists with a wealth of molecular 'hosts'. Ever since resurgence in the field during the 1970s and 1980s these hosts' similarities to natural structures, such the active sites of enzymes, have been noted. Latterly there has been great interest in the recently reported pillar[n]arenes. As if to underline the importance of these compounds, exciting applications are starting to emerge, from electrochemical sensors to antimicrobial agents. Novel uses appear destined to have an impact on clinical conditions from Alzheimer's disease to cancer treatment. In order to demonstrate the impact of pillar[n]arenes across the chemistry-biology interface this review will cover the current state of the art from biomimicry and analyte-specific detection to emerging clinical applications. Examples include pillar[n]arene-based ion channels, enzyme-responsive compounds, imaging agents, biofilm inhibiting derivatives, drug complexing and drug releasing systems.

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Section: Medical Applicationsmentioning

confidence: 99%

Pillar[n]arenes at the Chemistry‐Biology Interface

Cragg

2018

Israel Journal of Chemistry

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“…Wang and coworkers constructed a variety of supramolecular vesicles assembled from amphiphilic host-guest complex based on pillarenes for targeted drug delivery, since they fabricated the pH-responsive supramolecular vesicles based on CP[6]A and ferrocene 111. Subsequently, they developed drug delivery systems based on supramolecular amphiphiles, such as, multi-responsive supramolecular vesicles 112, chemo-photodynamic dual therapeutic vesicles 113, photo-responsive supramolecular vesicles based on azobenzene guest and pillar[6]arenes 114, DOX-based prodrug with pillar[6]arene 115, phosphate pillar[5,6]arene-based biocompatible vesicles 116, supramolecular vesicles assembled from pillar[5]arene and cationic polymer 117, GSH-responsive supramolecular vesicles based on D-galactose-modified pillar[5]arene 118, and glucose-responsive vesicles based on pillar[5]arenes and pyridylboronic acid 119. The supramolecular vesicles mentioned above were mainly applied for anticancer or insulin drug delivery.…”

Section: Supramolecular Therapeutic Systems With Pillarenes As Cormentioning

confidence: 99%

Supramolecular nanotheranostics based on pillarenes

et al. 2019

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With the rapid development of supramolecular chemistry and nanomaterials, supramolecular nanotheranostics has attracted remarkable attention owing to the advantages compared with conventional medicine. Supramolecular architectures relying on non-covalent interactions possess reversible and stimuli-responsive features; endowing supramolecular nanotheranostics based on supramolecular assemblies great potentials for the fabrication of integrated novel nanomedicines and controlled drug delivery systems. In particular, pillarenes, as a relatively new class of synthetic macrocycles, are important candidates in the construction of supramolecular therapeutic systems due to their excellent features such as rigid and symmetric structures, facile substitution, and unique host-guest properties. This review summarizes the development of pillarene-based supramolecular nanotheranostics for applications in biological mimicking, virus inhibition, cancer therapy, and diagnosis, which contains the following two major parts: (a) pillarene-based hybrid supramolecular nanotheranostics upon hybridizing with porous materials such as mesoporous silica nanoparticles, metal-organic frameworks, metal nanoparticles, and other inorganic materials; (b) pillarene-based organic supramolecular therapeutic systems that include supramolecular amphiphilic systems, artificial channels, and prodrugs based on host-guest complexes. Finally, perspectives on how pillarene-based supramolecular nanotheranostics will advance the field of pharmaceuticals and therapeutics are given.

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“…10). 90 In this example, polyglutamamide with butyl-ammonium (BA) groups was used as a polymer guest. Furthermore, the polymeric guest was equipped with a targeting biotin unit.…”

Section: Wp[n]-based Nanocarriers For Drug Deliverymentioning

confidence: 99%