Supramolecular self-assembled peptide-engineered nanofibers: A propitious proposition for cancer therapy

Pandey, Giriraj; Phatale, Vivek; Khairnar, Pooja; Kolipaka, Tejaswini; Shah, Saurabh; Famta, Paras; Jain, Naitik; Srinivasarao, Dadi A.; Rajinikanth, P.S.; Raghuvanshi, Rajeev Singh; Srivastava, Saurabh

doi:10.1016/j.ijbiomac.2023.128452

Cited by 5 publications

(2 citation statements)

References 203 publications

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“…At present, an extensive variety of nanoformulations have been developed and examined for the delivery of various therapeutics, such as vaccines, proteins, and nucleic acids. , NPs possess several benefits, including size-dependent physical characteristics, protection against chemical or proteolytic degradation, controlled release over a more extended period, and targeted delivery to specific body regions, which minimizes side effects. , Desai et al developed and examined the therapeutic effectiveness of the anti-nociception agent capsaicin (Cap) and anti-TNFα siRNA (siTNFα) entrapped polymeric NCs (CyLiPns) for the treatment of chronic inflammatory skin disorders . Currently, nanomedicines have been delivered using a variety of delivery strategies, including nasal, subcutaneous, oral, and intravenous injections .…”

Section: Superiority Of Nc-integrated Mns Over Other Drug Delivery Pl...mentioning

confidence: 99%

Nanocarrier-Integrated Microneedles: Divulging the Potential of Novel Frontiers for Fostering the Management of Skin Ailments

Khairnar,

Phatale,

Shukla

et al. 2024

Mol. Pharmaceutics

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The various kinds of nanocarriers (NCs) have been explored for the delivery of therapeutics designed for the management of skin manifestations. The NCs are considered as one of the promising approaches for the skin delivery of therapeutics attributable to sustained release and enhanced skin penetration. Despite the extensive applications of the NCs, the challenges in their delivery via skin barrier (majorly stratum corneum) have persisted. To overcome all the challenges associated with the delivery of NCs, the microneedle (MN) technology has emerged as a beacon of hope. Programmable drug release, being painless, and its minimally invasive nature make it an intriguing strategy to circumvent the multiple challenges associated with the various drug delivery systems. The integration of positive traits of NCs and MNs boosts therapeutic effectiveness by evading stratum corneum, facilitating the delivery of NCs through the skin and enhancing their targeted delivery. This review discusses the barrier function of skin, the importance of MNs, the types of MNs, and the superiority of NC-loaded MNs. We highlighted the applications of NC-integrated MNs for the management of various skin ailments, combinational drug delivery, active targeting, in vivo imaging, and as theranostics. The clinical trials, patent portfolio, and marketed products of drug/NC-integrated MNs are covered. Finally, regulatory hurdles toward benchtop-to-bedside translation, along with promising prospects needed to scale up NC-integrated MN technology, have been deliberated. The current review is anticipated to deliver thoughtful visions to researchers, clinicians, and formulation scientists for the successful development of the MN-technology-based product by carefully optimizing all the formulation variables.

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Section: Superiority Of Nc-integrated Mns Over Other Drug Delivery Pl...mentioning

confidence: 99%

Nanocarrier-Integrated Microneedles: Divulging the Potential of Novel Frontiers for Fostering the Management of Skin Ailments

Khairnar,

Phatale,

Shukla

et al. 2024

Mol. Pharmaceutics

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“…In fact, it has evolved beyond the chemical realm and now interfaces with physics, biology, pharmacy, and engineering. [3][4][5][6] This branch of chemistry encompasses a range of different types of compounds, including host-guest complexes, supramolecular polymers, hydrogels or self-assembled structures held together by reversible noncovalent interactions. [7][8][9] The plethora of intra-and intermolecular noncovalent interactions is responsible for the molecular diversity and complexity in the supramolecular domain.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular Chemistry: Exploring the Use of Electronic Structure, Molecular Dynamics, and Machine Learning Approaches

Colaço,

Glitz,

Jacobs

et al. 2024

Eur J Org Chem

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This review aims to highlight the role that computational chemistry has played in advancing the supramolecular chemistry field. We demonstrated recent uses of computational methodologies to elucidate noncovalent interactions in various processes occurring in supramolecular systems. We also emphasized the contributions of these techniques to studying reactions within confined space, showing how computational methodologies help clarify the effects of reactivity and conformational locking. Furthermore, we underscore the utilization of Molecular Dynamics (MD) in elucidating dynamical processes, understanding temperature and pressure effects, and exploring conformational space within supramolecular chemistry. Finally, we highlight the impact that the age of machine learning has on computational chemistry, showing how these universal approximators can enhance existing methods, predict properties, and efficiently explore the chemical space encompassed by these complex systems.

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Despicable role of epithelial–mesenchymal transition in breast cancer metastasis: Exhibiting de novo restorative regimens

Famta,

Shah,

Dey

et al. 2025

Cancer Pathogenesis and Therapy

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Supramolecular self-assembled peptide-engineered nanofibers: A propitious proposition for cancer therapy

Cited by 5 publications

References 203 publications

Nanocarrier-Integrated Microneedles: Divulging the Potential of Novel Frontiers for Fostering the Management of Skin Ailments

Nanocarrier-Integrated Microneedles: Divulging the Potential of Novel Frontiers for Fostering the Management of Skin Ailments

Supramolecular Chemistry: Exploring the Use of Electronic Structure, Molecular Dynamics, and Machine Learning Approaches

Despicable role of epithelial–mesenchymal transition in breast cancer metastasis: Exhibiting de novo restorative regimens

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